1,6-hexanediammonium dinitrate | 6143-53-9

• 物质功能分类: 有机原料 - 羧酸类化合物及衍生物
• 分子结构分类: 有机化合物 - 有机氧化合物 - 有机含氧阴离子化合物
• 英文名称: 1,6-hexanediammonium dinitrate
• 英文别名: hexanediyldiamine; dinitrate；Hexandiyldiamin; Dinitrat；Hexamethylenediammonium dinitrate；Hexane-1,6-diamine;nitric acid；hexane-1,6-diamine;nitric acid
• CAS: 6143-53-9
• 化学式: C₆H₁₈N₂*2NO₃
• 分子量: 242.232
• InChiKey: DSWXCSRFRCFTSM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.12
• 重原子数：
  12
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  118
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  盐酸 、 trans-[PtCl(NH₃)₂(OH)]•H₂O 、 1,6-hexanediammonium dinitrate 、 丙酮 以 N,N-二甲基甲酰胺 为溶剂， 以0%的产率得到trans-[Pt(NH3)2(1,6-hexanediamine)](2+)
  参考文献：
  名称：

  Synthetic Route to Dinuclear Platinum(II) Complexes [{trans-PtCl(NH₃)₂}₂(μ-L)]²⁺ (L = Aliphatic or Heterocyclic Diamine) as Potential Antitumor Agents, Exploiting the Mutual Activation of Hydroxido Ligands and Ammonium Groups

  摘要：

  A simple and efficient method for the synthesis of potentially antitumor-active dinuclear platinum complexes of the general formula [(trans-PtCl(NH3)(2)}(2)(mu-L)]((n+2)+) (L = aliphatic or heterocyclic diamine; n = charge of L) is presented. The procedure is based on the mutual in situ activation of trans-[PtCl(OH)(NH3)(2)] and the linker L in the form of a diammoniurn salt. This synthetic pathway yielded the Farrell compound [{trans-PtCl(NH3)(2)}(2){mu-NH2(CH2)(6)NH2)]Cl-2 (BBR3005) in quantitative yield. Using the same procedure, we prepared the new pyrazolate-bridged compound [{trans-PtCl(NH3)(2)(mu-pz)]Cl, determined its X-ray structure, and tested its cytotoxicity against three wild-type and one cisplatin-resistant cell lines.

  DOI：

  10.1021/ic801251k

文献信息

• BINDER FOR ABRASIVE ARTICLES, ABRASIVE ARTICLES INCLUDING THE SAME AND METHOD OF MAKING SAME
  申请人：3M Innovative Properties Company

  公开号：EP1425323B1

  公开（公告）日：2012-12-26
• US6682574B2
  申请人：——

  公开号：US6682574B2

  公开（公告）日：2004-01-27
• Synthetic Route to Dinuclear Platinum(II) Complexes [{<i>trans</i>-PtCl(NH₃)₂}₂(μ-L)]²⁺ (L = Aliphatic or Heterocyclic Diamine) as Potential Antitumor Agents, Exploiting the Mutual Activation of Hydroxido Ligands and Ammonium Groups
  作者：Claude Chopard、Christine Lenoir、Silvia Rizzato、Michel Vidal、Jorma Arpalahti、Laure Gabison、Alberto Albinati、Christiane Garbay、Jiří Kozelka

  DOI：10.1021/ic801251k

  日期：2008.10.20

  A simple and efficient method for the synthesis of potentially antitumor-active dinuclear platinum complexes of the general formula [(trans-PtCl(NH3)(2)}(2)(mu-L)]((n+2)+) (L = aliphatic or heterocyclic diamine; n = charge of L) is presented. The procedure is based on the mutual in situ activation of trans-[PtCl(OH)(NH3)(2)] and the linker L in the form of a diammoniurn salt. This synthetic pathway yielded the Farrell compound [trans-PtCl(NH3)(2)}(2)mu-NH2(CH2)(6)NH2)]Cl-2 (BBR3005) in quantitative yield. Using the same procedure, we prepared the new pyrazolate-bridged compound [trans-PtCl(NH3)(2)(mu-pz)]Cl, determined its X-ray structure, and tested its cytotoxicity against three wild-type and one cisplatin-resistant cell lines.