7-hydroxy-8-methylquinolin-2(1H)-one | 154521-00-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 7-hydroxy-8-methylquinolin-2(1H)-one
• 英文别名: 7-hydroxy-8-methyl-1H-quinolin-2-one
• CAS: 154521-00-3
• 化学式: C₁₀H₉NO₂
• 分子量: 175.187
• InChiKey: WWNSAAPSZDVGSR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  49.3
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  7-hydroxy-8-methylquinolin-2(1H)-one 在 吡啶 、 N-溴代丁二酰亚胺(NBS) 、 sodium azide 、 palladium 10% on activated carbon 、 三氟化硼乙醚 、 氢气 、 potassium carbonate 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 、 六氢吡啶-alpha-羧酸 、 维生素 C 作用下， 以 二氯甲烷 、 N,N-二甲基乙酰胺 、 乙酸乙酯 、 N,N-二甲基甲酰胺 为溶剂， 反应 78.0h， 生成 N-(2-(3-bromopropoxy)-7-(((3aR,4R,7R,7aR)-7-methoxy-6,6-dimethyl-2-oxotetrahydro-4H-[1,3]dioxolo[4,5-c]pyran-4-yl)oxy)-8-methylquinolin-3-yl)-3',6-dimethoxy-[1,1'-biphenyl]-3-carboxamide
  参考文献：
  名称：

  Synthesis and biological evaluation of coumarin replacements of novobiocin as Hsp90 inhibitors

  摘要：

  Since Hsp90 modulates all six hallmarks of cancer simultaneously, it has become an attractive target for the development of cancer chemotherapeutics. In an effort to develop more efficacious compounds for Hsp90 inhibition, novobiocin analogues were prepared by replacing the central coumarin core with naphthalene, quinolinone, and quinoline surrogates. These modifications allowed for modification of the 2-position, which was previously unexplored. Biological evaluation of these compounds suggests a hydrophobic pocket about the 2-position of novobiocin. Anti-proliferative activities of these analogues against multiple cancer cell lines identified 2-alkoxyquinoline derivatives to exhibit improved activity. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2013.12.056
• 作为产物：
  描述：

  2-甲基-3-硝基苯酚 在 吡啶 、 aluminum (III) chloride 、 palladium 10% on activated carbon 、 氢气 、 potassium carbonate 作用下， 以 乙酸乙酯 、 N,N-二甲基甲酰胺 、 氯苯 、 丙酮 为溶剂， 反应 26.0h， 生成 7-hydroxy-8-methylquinolin-2(1H)-one
  参考文献：
  名称：

  Synthesis and biological evaluation of coumarin replacements of novobiocin as Hsp90 inhibitors

  摘要：

  Since Hsp90 modulates all six hallmarks of cancer simultaneously, it has become an attractive target for the development of cancer chemotherapeutics. In an effort to develop more efficacious compounds for Hsp90 inhibition, novobiocin analogues were prepared by replacing the central coumarin core with naphthalene, quinolinone, and quinoline surrogates. These modifications allowed for modification of the 2-position, which was previously unexplored. Biological evaluation of these compounds suggests a hydrophobic pocket about the 2-position of novobiocin. Anti-proliferative activities of these analogues against multiple cancer cell lines identified 2-alkoxyquinoline derivatives to exhibit improved activity. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2013.12.056

文献信息

• Synthesis and biological evaluation of coumarin replacements of novobiocin as Hsp90 inhibitors
  作者：Bhaskar Reddy Kusuma、Anuj Khandelwal、Wen Gu、Douglas Brown、Weiya Liu、George Vielhauer、Jeffrey Holzbeierlein、Brian S.J. Blagg

  DOI：10.1016/j.bmc.2013.12.056

  日期：2014.2

  Since Hsp90 modulates all six hallmarks of cancer simultaneously, it has become an attractive target for the development of cancer chemotherapeutics. In an effort to develop more efficacious compounds for Hsp90 inhibition, novobiocin analogues were prepared by replacing the central coumarin core with naphthalene, quinolinone, and quinoline surrogates. These modifications allowed for modification of the 2-position, which was previously unexplored. Biological evaluation of these compounds suggests a hydrophobic pocket about the 2-position of novobiocin. Anti-proliferative activities of these analogues against multiple cancer cell lines identified 2-alkoxyquinoline derivatives to exhibit improved activity. (C) 2014 Elsevier Ltd. All rights reserved.