N-(3-氨基丙基)十六碳-1-酰胺 | 4899-97-2

• 物质功能分类: 有机原料 - 氨基化合物 - 酰胺类化合物
• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: N-(3-氨基丙基)十六碳-1-酰胺
• 英文名称: N-(3-aminopropyl)palmitanamide
• 英文别名: Hexadecanamide, N-(3-aminopropyl)-；N-(3-aminopropyl)hexadecanamide
• CAS: 4899-97-2
• 化学式: C₁₉H₄₀N₂O
• 分子量: 312.539
• InChiKey: IHRBDIQRJRJFES-UHFFFAOYSA-N

物化性质

• 沸点：
  466.4±28.0 °C(Predicted)
• 密度：
  0.888±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  6.3
• 重原子数：
  22
• 可旋转键数：
  17
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.95
• 拓扑面积：
  55.1
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  棕榈酸甲酯 、 1,3-丙二胺 以 甲醇 为溶剂， 反应 48.0h， 以87%的产率得到N-(3-氨基丙基)十六碳-1-酰胺
  参考文献：
  名称：

  一系列新型N-酰基二胺作为潜在的抗菌和抗真菌剂的合成和生物学评价

  摘要：

  为了继续努力寻找新的抗菌化合物，从脂肪甲酯和1,2-乙二胺，1,3-丙二胺或1,4-丁二胺制备了一系列的脂肪N-酰基二胺。筛选合成的化合物对革兰氏阳性菌（金黄色葡萄球菌，表皮葡萄球菌），革兰氏阴性菌（大肠杆菌，铜绿假单胞菌）的抗菌活性以及对四种念珠菌（C. albicans，C.热带，光滑念珠菌和近平滑念珠菌）。化合物5a（N-（2-氨基乙基）十二碳酰胺），5b（N-（2-氨基乙基）四碳酰胺）和6d（N-（3-氨基丙基）油酰胺）对革兰氏阳性细菌的活性最高，MIC值为1至16并评估其对21种耐甲氧西林金黄色葡萄球菌临床分离株的活性。所有化合物均表现出良好至中等的抗真菌活性。与氯霉素相比，化合物6b表现出相似的活性（MIC 50  = 16μg/ mL）。亲脂性和生物学活性之间可以建立正相关。

  DOI：

  10.1016/j.bmcl.2014.08.047

文献信息

• Carbamates from Glycerine Carbonate for Pearlization
  申请人：Evonik Industries AG

  公开号：US20150044264A1

  公开（公告）日：2015-02-12

  Alkyl and/or alkenyl glycerol carbamate prepared by reacting a carbonate selected from the group consisting of glycerol carbonate, diglycerol carbonate, polyglycerol carbonate and mixtures thereof, with an amine of the general formula (I): HNR 1 R 2 (I) wherein R 1 represents a hydrogen atom or a hydrocarbon group selected from the group consisting of alkyl groups and alkenyl groups having from 1 to 22 carbon atoms and R 2 represents a hydrocarbon group selected from the group consisting of alkyl groups and alkenyl groups having from 4 to 22 carbon atoms, and cyclic alkyl groups having 5 or 6 carbon atoms, are described along with methods for their use as pearlizing agents in surface-active preparations.

  通过将选自由甘油碳酸酯、二甘油碳酸酯、多甘油碳酸酯和其混合物的碳酸酯与通式（I）的胺反应制备烷基和/或烯基甘油氨基甲酸酯，其中R1表示氢原子或由1到22个碳原子的烷基和烯基基团组成的羟基碳基，R2表示由4到22个碳原子的烷基和烯基基团以及具有5或6个碳原子的环烷基组成的羟基碳基。同时还描述了它们作为表面活性制剂中珠光剂的使用方法。
• Oil-in-water emulsion of organopolysiloxane and method for the preparation thereof
  申请人：SHIN-ETSU CHEMICAL CO., LTD.

  公开号：EP1010717A2

  公开（公告）日：2000-06-21

  An oil-in-water aqueous emulsion of a high-viscosity organopolysiloxane compound, which is suitable as an adjuvant in a hair-care treatment toiletry preparation, is disclosed. The emulsifier ingredient in the aqueous emulsion is a combination of a fatty acid amidoamine compound, e.g., dimethylaminopropyl stearamide, and an organic acid, e.g., lactic acid and amino acids, jointly forming a water-soluble fatty acid amidoamine salt compound having surface activity further in combination with a polyoxyalkylene-modified organopolysiloxane as a surface activity promoter.

  本发明公开了一种高粘度有机聚硅氧烷化合物的水包油型水乳液，该乳液可用作护发护理洗浴用品制剂中的辅助剂。该水乳剂中的乳化剂成分是脂肪酸氨基胺化合物（如二甲基氨基丙基硬脂酰胺）与有机酸（如乳酸和氨基酸）的组合，共同形成具有表面活性的水溶性脂肪酸氨基胺盐化合物，并与作为表面活性促进剂的聚氧亚烷基改性有机聚硅氧烷结合。
• Conditioning composition for hair
  申请人：KPSS-Kao Professional Salon Services GmbH

  公开号：EP2161016A1

  公开（公告）日：2010-03-10

  Summary The present invention is related to an aqueous conditioning composition for hair comprising at least one alkyl ester/amido alkyl amine or alkyl ester/amido alkyl quaternary amine and an aqueous emulsion of divinyldimethicone/dimethicone copolymer. In particular, a conditioning composition for hair comprising at least one compound according to general structure         R1-A-R2-B wherein R1 is a saturated or unsaturated, straight or branched alkyl group with 8 to 24 C atoms, R2 is a straight or branched alkyl group with 1 to 4 C atoms, A is a group selected from O, and B is selected from wherein R3 and R4 are the same or different is H or an alkyl with 1 to 4 C atoms, hydroxyl alkyl with 1 to 4 C atoms and di hydroxyl alkyl with 2 to 4 C atoms, R5, and R6 are the same or different, an alkyl with 1 to 4 C atoms, hydroxyl alkyl with 1 to 4 C atoms and di hydroxyl alkyl with 2 to 4 C atoms, R7 is an alkyl with 1 to 4 C atoms, hydroxyl alkyl with 1 to 4 C atoms or di hydroxyl alkyl with 2 to 4 C atoms and         -R2-A-R1 wherein R1. A and R2 have the above meaning and X is chloride, bromide, methosulfate and an aqueous emulsion of divinyldimethicone/dimethicone copolymer with an internal phase viscosity of more than 1 x 108 mm2/s measured at 0.01 Hz and at approximately 25°C

  摘要 本发明涉及一种用于头发的水性护理组合物，该组合物包含至少一种烷基酯/氨基烷基胺或烷基酯/氨基烷基季胺和二乙烯基二甲基硅氧烷/二甲基硅氧烷共聚物的水性乳液。特别是一种头发护理组合物，它包含至少一种符合一般结构的化合物 R1-A-R2-B 其中 R1 是具有 8 至 24 个 C 原子的饱和或不饱和、直链或支链烷基，R2 是具有 1 至 4 个 C 原子的直链或支链烷基，A 是选自 O.A.B.的基团、 B 选自 其中 R3 和 R4 相同或不同，是 H 或具有 1 至 4 个 C 原子的烷基、具有 1 至 4 个 C 原子的羟基烷基和具有 2 至 4 个 C 原子的二羟基烷基，R5 和 R6 相同或不同，是具有 1 至 4 个 C 原子的烷基、具有 1 至 4 个 C 原子的羟基烷基和具有 2 至 4 个 C 原子的二羟基烷基，R7 是具有 1 至 4 个 C 原子的烷基、具有 1 至 4 个 C 原子的羟基烷基或具有 2 至 4 个 C 原子的二羟基烷基，以及 R8 是具有 1 至 4 个 C 原子的烷基、具有 1 至 4 个 C 原子的羟基烷基或具有 2 至 4 个 C 原子的二羟基烷基。 -R2-A-R1 其中 R1.A 和 R2 具有上述含义，X 是氯化物、溴化物、甲硫酸盐和二乙烯基二甲基硅氧烷/二甲基硅氧烷共聚物的水乳液，其内相粘度在 0.01 Hz 和约 25°C 时测量值大于 1 x 108 mm2/s。
• Colouring composition
  申请人：KPSS-Kao Professional Salon Services GmbH

  公开号：EP2177204A1

  公开（公告）日：2010-04-21

  The present invention is related to an aqueous oxidative colouring composition for keratin fibres especially human hair. The inventors of the present invention have surprisingly found out that a composition comprising at least one oxidative dye precursor and optionally at least one coupling agent and an aqueous emulsion of divinyldimethicone/dimethicone copolymer with an internal phase viscosity of more than 1 x 108 mm2/s measured at 0.01 Hz and at about 25°C and at least one alkyl ether or ester or amine alkyl amine or quaternary ammonium compound colours hair excellently and improves hair shine, combability and manageability and especially hair coloured with such composition has less flyaways. Additionally it has been observed that hair coloured homogeneously. Accordingly, the present invention is an aqueous hair colouring composition comprising at least one oxidative dye precursor, optionally at least one coupling agent, an aqueous emulsion of divinyldimethicone/dimethicone copolymer with an internal phase viscosity of more than 1 x 108 mm2/s measured at 0.01 Hz and at about 25°C and at least one compound according to general structure          R1-A-R2-B wherein R1 is a saturated or unsaturated, straight or branched alkyl group with 8 to 24 C atoms, R2 is a straight or branched alkyl group with 1 to 4 C atoms, A is a group selected from O, and B is selected from wherein R3 and R4 are the same or different is H or an alkyl with 1 to 4 C atoms, hydroxyl alkyl with 1 to 4 C atoms and di hydroxyl alkyl with 2 to 4 C atoms, R5, and R6 are the same or different, an alkyl with 1 to 4 C atoms, hydroxyl alkyl with 1 to 4 C atoms and di hydroxyl alkyl with 2 to 4 C atoms, R7 is an alkyl with 1 to 4 C atoms, hydroxyl alkyl with 1 to 4 C atoms or di hydroxyl alkyl with 2 to 4 C atoms and          -R2-A-R1 wherein R1, A and R2 have the above meaning and X is chloride, bromide, methosulfate.

  本发明涉及一种用于角蛋白纤维，特别是人类头发的水性氧化染色组合物。本发明的发明者惊奇地发现，一种组合物包含至少一种氧化染色前体和任选的至少一种偶联剂，以及二乙烯基二甲基硅氧烷/二甲基硅氧烷共聚物的水性乳液，其内相粘度在 0.01赫兹和约25°C时测得的内相粘度大于1 x 108 mm2/s的二乙烯基二甲基硅氧烷/二甲基硅氧烷共聚物水乳液，以及至少一种烷基醚或酯或胺烷基胺或季铵盐化合物，可使头发着色效果极佳，并改善头发的光泽度、梳理性和易打理性，特别是用这种组合物染色的头发不易飞扬。此外，还观察到头发着色均匀。因此，本发明是一种水性染发组合物，它包含至少一种氧化性染料前体、可选的至少一种偶联剂、二乙烯基二甲基硅氧烷/二甲基硅氧烷共聚物的水性乳液（在 0.01 Hz 和约 25°C 时测量其内相粘度大于 1 x 108 mm2/s）和至少一种符合一般结构的化合物。 R1-A-R2-B 其中 R1 是具有 8 至 24 个 C 原子的饱和或不饱和、直链或支链烷基，R2 是具有 1 至 4 个 C 原子的直链或支链烷基，A 是选自 O.A.B 的基团、 B 选自 其中 R3 和 R4 相同或不同是 H 或具有 1 至 4 个 C 原子的烷基、具有 1 至 4 个 C 原子的羟基烷基和具有 2 至 4 个 C 原子的二羟基烷基、 R5 和 R6 相同或不同，是具有 1 至 4 个 C 原子的烷基、具有 1 至 4 个 C 原子的羟基烷基和具有 2 至 4 个 C 原子的二羟基烷基，R7 是具有 1 至 4 个 C 原子的烷基、具有 1 至 4 个 C 原子的羟基烷基或具有 2 至 4 个 C 原子的二羟基烷基，R8 是具有 1 至 4 个 C 原子的烷基、具有 1 至 4 个 C 原子的羟基烷基或具有 2 至 4 个 C 原子的二羟基烷基。 -R2-A-R1 其中 R1、A 和 R2 具有上述含义，X 为氯化物、溴化物、甲硫酸盐。
• Composition for the permanent shaping of human hair
  申请人：KPSS-Kao Professional Salon Services GmbH

  公开号：EP2177205A1

  公开（公告）日：2010-04-21

  The present invention concerns a composition for the permanent shaping of human hair used both for the permanent waving of human hair with an excellent waving effect as well as for the straightening of either naturally or chemically curled hair. The present invention starts from the task of providing a composition for the permanent shaping of human hair with excellent waving and straightening performance. Hair waved or straightened with composition disclosed herein looks and feels natural upon touching by hand. For waved hair it is especially important that the hair has excellent elasticity and bounce. The present invention is a composition for permanent shaping and/or straightening hair based on at least one reducing agent further comprising an aqueous emulsion of divinyldimethicone/dimethicone copolymer with an internal phase viscosity of more than 1 x 108 mm2/s measured at 0.01 Hz and at about 25°C, and at least one compound according to general structu re          R1-A-R2- B wherein R1 is a saturated or unsaturated, straight or branched alkyl group with 8 to 24 C atoms, R2 is a straight or branched alkyl group with 1 to 4 C atoms, A is a group selected from O, and B is selected from wherein R3 and R4 are the same or different is H or an alkyl with 1 to 4 C atoms, hydroxyl alkyl with 1 to 4 C atoms and di hydroxyl alkyl with 2 to 4 C atoms, R5, and R6 are the same or different, an alkyl with 1 to 4 C atoms, hydroxyl alkyl with 1 to 4 C atoms and di hydroxyl alkyl with 2 to 4 C atoms, R7 is an alkyl with 1 to 4 C atoms, hydroxyl alkyl with 1 to 4 C atoms or di hydroxyl alkyl with 2 to 4 C atoms and wherein R1, A and R2 have the above meaning and X is chloride, bromide, methosulfate.

  本发明涉及一种用于人类头发永久定型的组合物，这种组合物既可用于人类头发的永久定型，具有极佳的定型效果，也可用于自然卷发或化学卷发的拉直。本发明的出发点是提供一种用于永久塑造人类头发的组合物，该组合物具有极佳的编发和拉直效果。使用本发明公开的组合物编织或拉直的头发，用手触摸时看起来感觉自然。对于挥发的头发来说，头发具有出色的弹性和回弹性尤为重要。本发明是一种用于永久定型和/或拉直头发的组合物，该组合物基于至少一种还原剂，其 中还包括二乙烯基二甲基硅氧烷/二甲基硅氧烷共聚物水乳液（在 0.01 赫兹和约 25°C 下测得其内相粘度大于 1 x 108 mm2/s）和至少一种符合一般结构式的化合物。 R1-A-R2- B 其中 R1 是具有 8 至 24 个 C 原子的饱和或不饱和直链或支链烷基，R2 是具有 1 至 4 个 C 原子的直链或支链烷基，A 是选自 O.A.B.的基团、 B 选自 其中 R3 和 R4 相同或不同，是 H 或具有 1 至 4 个 C 原子的烷基、具有 1 至 4 个 C 原子的羟基烷基和具有 2 至 4 个 C 原子的二羟基烷基，R5 和 R6 相同或不同，是具有 1 至 4 个 C 原子的烷基、具有 1 至 4 个 C 原子的羟基烷基和具有 2 至 4 个 C 原子的二羟基烷基，R7 是具有 1 至 4 个 C 原子的烷基、具有 1 至 4 个 C 原子的羟基烷基或具有 2 至 4 个 C 原子的二羟基烷基，以及 R8 是具有 1 至 4 个 C 原子的烷基、具有 1 至 4 个 C 原子的羟基烷基或具有 2 至 4 个 C 原子的二羟基烷基。 其中 R1、A 和 R2 具有上述含义，X 为氯化物、溴化物、甲硫酸盐。