N-(3-氨基丙基)十八烷酰胺 | 35567-30-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: N-(3-氨基丙基)十八烷酰胺
• 英文名称: N-(3-aminopropyl)stearamide
• 英文别名: N-(3-aminopropyl)octadecanamide；aminopropyl stearamide；Octadecanamide, N-(3-aminopropyl)-
• CAS: 35567-30-7
• 化学式: C₂₁H₄₄N₂O
• 分子量: 340.593
• InChiKey: YTJWICLLALFBPN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.4
• 重原子数：
  24
• 可旋转键数：
  19
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.95
• 拓扑面积：
  55.1
• 氢给体数：
  2
• 氢受体数：
  2

安全信息

• 海关编码：
  2924199090

反应信息

• 作为反应物：
  描述：

  N-(3-氨基丙基)十八烷酰胺 、 1-methyl-4-[1-methyl-4-(1-methyl-1H-pyrrole-2-amido)-1H-pyrrole-2-amido]-1H-pyrrole-2-carboxylic acid 在 1-羟基苯并三唑 、 N,N'-二异丙基碳二亚胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 24.0h， 以45%的产率得到1-methyl-N-[1-methyl-5-[3-(octadecanoylamino)propylcarbamoyl]pyrrol-3-yl]-4-[(1-methylpyrrole-2-carbonyl)amino]pyrrole-2-carboxamide
  参考文献：
  名称：

  Synthesis of Lipid Derivatives of Pyrrole Polyamide and Their Biological Activity

  摘要：

  合成了新型脂肪酰和磷脂衍生物的吡咯聚酰胺。对其在MT-4细胞癌细胞系及人类免疫缺陷病毒（HIV）感染细胞中的细胞毒性进行了研究。尽管未发现抗HIV活性，但通过在吡咯聚酰胺中引入疏水基团，其对癌细胞的细胞毒性显著增强。

  DOI：

  10.1271/bbb.60650
• 作为产物：
  描述：

  tert-butyl(3-stearamidopropyl)carbamate 在 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 反应 1.0h， 生成 N-(3-氨基丙基)十八烷酰胺
  参考文献：
  名称：

  小分子TLR7 / 8激动剂的聚合物脂质两亲结合物对天然免疫活化的有效淋巴转移和空间控制。

  摘要：

  不受控制的全身性炎症免疫触发已阻碍了几类小分子免疫调节剂的临床翻译，例如用于疫苗设计和癌症免疫疗法的咪唑并喹啉TLR7 / 8激动剂。通过利用脂质基序固有的血清蛋白结合特性及其在淋巴样组织中积累的趋势，我们设计了两亲性脂质-聚合物共轭物，它们抑制了全身性炎症，但激发了有效的淋巴结免疫激活。这项工作为脂质聚合物两亲物的优化淋巴靶向设计提供了合理的基础。

  DOI：

  10.1002/anie.201905687

文献信息

• Oil-in-water emulsion of organopolysiloxane and method for the preparation thereof
  申请人：SHIN-ETSU CHEMICAL CO., LTD.

  公开号：EP1010717A2

  公开（公告）日：2000-06-21

  An oil-in-water aqueous emulsion of a high-viscosity organopolysiloxane compound, which is suitable as an adjuvant in a hair-care treatment toiletry preparation, is disclosed. The emulsifier ingredient in the aqueous emulsion is a combination of a fatty acid amidoamine compound, e.g., dimethylaminopropyl stearamide, and an organic acid, e.g., lactic acid and amino acids, jointly forming a water-soluble fatty acid amidoamine salt compound having surface activity further in combination with a polyoxyalkylene-modified organopolysiloxane as a surface activity promoter.

  本发明公开了一种高粘度有机聚硅氧烷化合物的水包油型水乳液，该乳液可用作护发护理洗浴用品制剂中的辅助剂。该水乳剂中的乳化剂成分是脂肪酸氨基胺化合物（如二甲基氨基丙基硬脂酰胺）与有机酸（如乳酸和氨基酸）的组合，共同形成具有表面活性的水溶性脂肪酸氨基胺盐化合物，并与作为表面活性促进剂的聚氧亚烷基改性有机聚硅氧烷结合。
• Hair conditioning composition
  申请人：KPSS-Kao Professional Salon Services GmbH

  公开号：EP1479368A1

  公开（公告）日：2004-11-24

  The present invention relates to a transparent gel type of hair conditioner composition showing relatively low viscosity changes at fluctuating temperatures and comprising at least one cationic polymer, polyquaternium 37, as a thickener and stabilizer and free from fatty alcohols, and, therefore, not in the emulsion from which is especially excellently suitable for rinse off application as well as leave in application.

  本发明涉及一种透明凝胶型护发素组合物，该组合物在温度波动时粘度变化相对较小，至少含有一种阳离子聚合物聚季铵盐 37 作为增稠剂和稳定剂，不含脂肪醇，因此不含乳液，特别适合冲洗和静置使用。
• Hair coloring conditioning composition
  申请人：KPSS-Kao Professional Salon Services GmbH

  公开号：EP1502578A1

  公开（公告）日：2005-02-02

  The present invention relates to a transparent colouring hair conditioner composition showing relatively low viscosity changes at fluctuating temperatures and comprising at least one cationic polymer, polyquatemium 37, as a thickener and stabilizer and at least one direct acting cationic dyestuff and free from fatty alcohols, and, therefore, not in the emulsion form which is especially excellently suitable for rinse off application as well as leave in application. The conditioner composition of the present invention further comprises at least one solubilizer selected from non-ionic, cationic and/or amphoteric surfactants. Furthermore, the conditioners of the present invention include active ingredients selected from hair restructuring ingredients, moisturising ingredients and natural plant extracts showing hair conditioning and/or restructuring benefits.

  本发明涉及一种透明染发护发素组合物，该组合物在温度波动时粘度变化相对较低，包含至少一种阳离子聚合物（聚奎特铵 37）作为增稠剂和稳定剂，以及至少一种直接作用的阳离子染料，不含脂肪醇，因此不呈乳液状，特别适合冲洗和静置使用。本发明的护发素组合物还包含至少一种增溶剂，选自非离子、阳离子和/或两性表面活性剂。此外，本发明的护发素还包括从头发结构调整成分、保湿成分和具有头发调理和/或结构调整功效的天然植物提取物中选出的活性成分。
• Conditioning and coloring composition for Hair
  申请人：KPSS-Kao Professional Salon Services GmbH

  公开号：EP1656969A1

  公开（公告）日：2006-05-17

  The present invention concerns a conditioning and colouring composition for hair showing optimum conditioning properties especially shine, softness and manageability. Hair conditioning composition comprising at least one hair conditioning compound, at least one cationic hair dye and at least one dicarboxylic acid and/or hydroxycarboxylic acid, show optimum performance in colour enhancing and especially surprisingly superior performance in hair shine improvement, excellently improving hair manageability and softness.

  本发明涉及一种护发和染发组合物，具有最佳的护发特性，尤其是光泽、柔软和易打理性。由至少一种护发化合物、至少一种阳离子染发剂和至少一种二羧酸和/或羟基羧酸组成的护发组合物在增色方面表现出最佳性能，尤其是在改善头发光泽、出色地改善头发的易打理性和柔软度方面表现出令人惊讶的卓越性能。
• Conditioning composition for hair comprising optical brightener
  申请人：KPSS-Kao Professional Salon Services GmbH

  公开号：EP1674070A1

  公开（公告）日：2006-06-28

  The present invention is related to a conditioning composition for hair comprising optical brightener. The conditioning composition of the present invention can be in the form of a shampoo, cleansing - conditioning composition, or in the form of a conditioner used after use of cleansing compositions. The preferred optical brightener is disodium distyrylbiphenyl disulfonate.

  本发明涉及一种含有光学增白剂的护发组合物。本发明的护发组合物可以是洗发水、清洁-护发组合物，也可以是在使用清洁组合物后使用的护发素。首选的光学增白剂是二丙烯酰联苯二磺酸钠。