7-hydroxy-3-(naphthalen-1-yl)-4H-chromen-4-one | 62845-17-4

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 异黄酮类化合物
• 英文名称: 7-hydroxy-3-(naphthalen-1-yl)-4H-chromen-4-one
• 英文别名: 7-hydroxy-3-(naphth-1-yl)-4-oxo-4H-benzopyran；7-hydroxy-3-naphthalen-1-ylchromen-4-one
• CAS: 62845-17-4
• 化学式: C₁₉H₁₂O₃
• 分子量: 288.302
• InChiKey: OVMFAKJMOZAYNH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  22
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  7-hydroxy-3-(naphthalen-1-yl)-4H-chromen-4-one 在 sodium hydride 作用下， 以 1,4-二氧六环 、 N,N-二甲基甲酰胺 为溶剂， 反应 27.0h， 生成 3-(naphthalen-1-yl)-7-[4-(piperazin-1-yl)butoxy]-4H-1-benzopyran-4-one bis[hydrochloride]
  参考文献：
  名称：

  Novel Basic Isoflavones as Inhibitors of Bone Resorption

  摘要：

  A number of aminoalkoxy analogues of ipriflavone (=7-(1-methylethoxy)isoflavone) were prepared and examined for their capacity to inhibit bone resorption induced by bovine parathyroid hormone fragment 1 - 34. Good-to-high activities were found for 7-(aminoalkoxy)isoflavone. analogues. Their activity was influenced by a number of structural features, among which the length of the basic side chain, the basicity of the amino group, and the nature and position of substituents on the 3-phenyl ring. 4'-(Aminoalkoxy)ipriflavone derivatives were less active.

  DOI：

  10.1002/1522-2675(20010815)84:8<2417::aid-hlca2417>3.0.co;2-n
• 作为产物：
  描述：

  1-萘乙酸 、 间苯二酚 在 三氟化硼乙醚 、 甲基磺酰氯 作用下， 反应 5.0h， 生成 7-hydroxy-3-(naphthalen-1-yl)-4H-chromen-4-one
  参考文献：
  名称：

  Development of 3-alkyl-6-methoxy-7-hydroxy-chromones (AMHCs) from natural isoflavones, a new class of fluorescent scaffolds for biological imaging

  摘要：

  一种新型荧光物质3-烷基-6-甲氧基-7-羟基-香豆素（AMHCs）已开发，并适用于生物成像试剂。

  DOI：

  10.1039/c4cc06762b

文献信息

• US4117149A
  申请人：——

  公开号：US4117149A

  公开（公告）日：1978-09-26
• Novel Basic Isoflavones as Inhibitors of Bone Resorption
  作者：Maurizio Delcanale、Gabriele Amari、Elisabetta Armani、Milco Lipreri、Maurizio Civelli、Elisabetta Galbiati、Massimo Giossi、Paola Lorenza Caruso、Patrizia Crivori、Pierre-Alain Carrupt、Bernard Testa

  DOI：10.1002/1522-2675(20010815)84:8<2417::aid-hlca2417>3.0.co;2-n

  日期：2001.8.15

  A number of aminoalkoxy analogues of ipriflavone (=7-(1-methylethoxy)isoflavone) were prepared and examined for their capacity to inhibit bone resorption induced by bovine parathyroid hormone fragment 1 - 34. Good-to-high activities were found for 7-(aminoalkoxy)isoflavone. analogues. Their activity was influenced by a number of structural features, among which the length of the basic side chain, the basicity of the amino group, and the nature and position of substituents on the 3-phenyl ring. 4'-(Aminoalkoxy)ipriflavone derivatives were less active.
• Development of 3-alkyl-6-methoxy-7-hydroxy-chromones (AMHCs) from natural isoflavones, a new class of fluorescent scaffolds for biological imaging
  作者：Jianzhuang Miao、Huaqing Cui、Jing Jin、Fangfang Lai、Hui Wen、Xiang Zhang、Gian Filippo Ruda、Xiaoguang Chen、Dali Yin

  DOI：10.1039/c4cc06762b

  日期：——

  A new class of fluorophores 3-alkyl-6-methoxy-7-hydroxy-chromones (AMHCs) is developed and is suitable as reagents for biological imaging.

  一种新型荧光物质3-烷基-6-甲氧基-7-羟基-香豆素（AMHCs）已开发，并适用于生物成像试剂。