methyl (methyl 5-acetamido-7-O-acetyl-3,5-dideoxy-8,9-O-isopropylidene-4-O-tert-butyldimethylsilyl-D-glycero-α-D-galacto-nonulopyranosid)onate | 121409-10-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: methyl (methyl 5-acetamido-7-O-acetyl-3,5-dideoxy-8,9-O-isopropylidene-4-O-tert-butyldimethylsilyl-D-glycero-α-D-galacto-nonulopyranosid)onate
• CAS: 121409-10-7
• 化学式: C₂₄H₄₃NO₁₀Si
• 分子量: 533.692
• InChiKey: XKOHHDGOCFOFIQ-JYVOXJRUSA-N

反应信息

• 作为反应物：
  描述：

  methyl (methyl 5-acetamido-7-O-acetyl-3,5-dideoxy-8,9-O-isopropylidene-4-O-tert-butyldimethylsilyl-D-glycero-α-D-galacto-nonulopyranosid)onate 在 溶剂黄146 作用下， 反应 3.0h， 以94%的产率得到methyl (methyl 5-acetamido-7-O-acetyl-3,5-dideoxy-D-glycero-α-D-galacto-nonulopyranosid)onate
  参考文献：
  名称：

  Synthesis of 7-O-acetyl-N-acetylneuraminic acid derivative.

  摘要：

  Selective protection of the C-4, C-8, and C-9 hydroxy groups of methyl (methyl 5-acetamido-3, 5-dideoxy-D-glycero-α-D-galacto-nonulopyranosid) onate followed by acetylation of the C-7 hy-droxy group gave a 7-O-acetyl-N-acetylneuraminic acid derivative.

  DOI：

  10.1248/cpb.36.4976
• 作为产物：
  描述：

  methyl N-acetilneuraminate α-methyl glucoside 在 吡啶 、 咪唑 、 对甲苯磺酸 作用下， 以 N,N-二甲基甲酰胺 、 丙酮 为溶剂， 反应 12.0h， 生成 methyl (methyl 5-acetamido-7-O-acetyl-3,5-dideoxy-8,9-O-isopropylidene-4-O-tert-butyldimethylsilyl-D-glycero-α-D-galacto-nonulopyranosid)onate
  参考文献：
  名称：

  Synthesis of 7-O-acetyl-N-acetylneuraminic acid derivative.

  摘要：

  Selective protection of the C-4, C-8, and C-9 hydroxy groups of methyl (methyl 5-acetamido-3, 5-dideoxy-D-glycero-α-D-galacto-nonulopyranosid) onate followed by acetylation of the C-7 hy-droxy group gave a 7-O-acetyl-N-acetylneuraminic acid derivative.

  DOI：

  10.1248/cpb.36.4976