13-methoxyberberine | 54260-75-2

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 原小檗碱生物碱及其衍生物
• 英文名称: 13-methoxyberberine
• 英文别名: 9,10,13-trimethoxy-5,6-dihydro-[1,3]dioxolo[4,5-g]isoquino[3,2-a]isoquinolinylium; chloride
• CAS: 54260-75-2
• 化学式: C₂₁H₂₀NO₅*Cl
• 分子量: 401.847
• InChiKey: DQHHSAMBLGWIKF-UHFFFAOYSA-M

反应信息

• 作为产物：
  描述：

  、 碘甲烷 生成 13-methoxyberberine
  参考文献：
  名称：

  Structure-Activity Relationships of Protoberberines Having Antimicrobial Activity

  摘要：

  13-Alkyl derivatives (2-6 and 8-12) of berberine (1) and palmatine (7) were subjected to in vitro antibacterial activity tests against Bacillus subtilis and Salmonella enteritidis. Antibacterial activity increased as the length of the C-13 aliphatic side chain increased. The effects of the oxygen substituents on aromatic rings A, C, and D of protoberberinium salts 13-20 on the antimicrobial activity against Staphylococcus aureus, B. subtilis, S. enteritidis, Escherichia coli, and Candida albicans are also discussed. The change in lipophilicity of the protoberberinium salts caused by modification of the substituents appears to influence the antibacterial activity. 13-Hexylberberine (6) and 13-hexylpalmatine (12) exhibited the greatest antibacterial activity.

  DOI：

  10.1055/s-2006-957572