| 288153-46-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• CAS: 288153-46-8
• 化学式: C₆₇H₈₅NO₁₇Si₂
• 分子量: 1232.58
• InChiKey: GGTULNAPOZKOEQ-QRVBHWGPSA-N

反应信息

• 作为反应物：
  描述：

  在 potassium carbonate 作用下， 以 甲醇 为溶剂， 生成 6-α-hydroxy-2'-O-triethylsilyl-7-α-paclitaxel
  参考文献：
  名称：

  Stereospecific synthesis of the major human metabolite of paclitaxel

  摘要：

  The stereospecific synthesis of 6-alpha-hydroxy paclitaxel 10, the major human metabolite of paclitaxel, is described. The 6,7-alpha-diol 4, obtained from paclitaxel, is converted to the 6,7-beta-cyclic sulfate followed by nitrate addition and reduction to afford the title compound. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(00)00707-3
• 作为产物：
  描述：

  6-α-hydroxy-2'-O-triethylsilyl-7-α-paclitaxel 在 咪唑 、 三乙胺 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 生成
  参考文献：
  名称：

  Stereospecific synthesis of the major human metabolite of paclitaxel

  摘要：

  The stereospecific synthesis of 6-alpha-hydroxy paclitaxel 10, the major human metabolite of paclitaxel, is described. The 6,7-alpha-diol 4, obtained from paclitaxel, is converted to the 6,7-beta-cyclic sulfate followed by nitrate addition and reduction to afford the title compound. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(00)00707-3