methyl (1R,3R)-3-((S)-1-(tert-butoxycarbonylamino)-4-methoxy-4-oxobutan-2-yl)-2,2-dimethylcyclobutanecarboxylate | 1138793-62-0

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: methyl (1R,3R)-3-((S)-1-(tert-butoxycarbonylamino)-4-methoxy-4-oxobutan-2-yl)-2,2-dimethylcyclobutanecarboxylate
• CAS: 1138793-62-0
• 化学式: C₁₈H₃₁NO₆
• 分子量: 357.447
• InChiKey: NUFQZERJQFPOFA-UPJWGTAASA-N

物化性质

• 沸点：
  438.9±20.0 °C(predicted)
• 密度：
  1.081±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

反应信息

• 作为产物：
  描述：

  、 碘甲烷 在 caesium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 16.0h， 生成 methyl (1R,3R)-3-((S)-1-(tert-butoxycarbonylamino)-4-methoxy-4-oxobutan-2-yl)-2,2-dimethylcyclobutanecarboxylate
  参考文献：
  名称：

  Stereoselective synthesis of cyclobutyl γ-amino acids leading to branched peptides with a cyclobutane core

  摘要：

  Alternative synthetic routes are provided to synthesize gamma-amino acids in their free form or conveniently protected for their selective incorporation into ramified gamma-peptides with a cyclobutane core. The key synthetic-step involves the stereoselective conjugate addition of nitromethane to chiral cyclobutyl alkenoates prepared from (-)-verbenone. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2008.12.019