2-甲基-4,5,7-三氯喹啉 | 203626-80-6

• 物质功能分类: 医药中间体 - 杂环化合物 - 喹啉类化合物
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 中文名称: 2-甲基-4,5,7-三氯喹啉
• 英文名称: 2-methyl-4,5,7-trichloroquinoline
• 英文别名: 4,5,7-trichloro-2-methylquinoline
• CAS: 203626-80-6
• 化学式: C₁₀H₆Cl₃N
• 分子量: 246.523
• InChiKey: DSRVLGATYHLALY-UHFFFAOYSA-N

物化性质

• 沸点：
  333.9±37.0 °C(Predicted)
• 密度：
  1.459±0.06 g/cm3(Predicted)
• 溶解度：
  可溶于氯仿（少许）、甲醇（少许）

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  14
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  12.9
• 氢给体数：
  0
• 氢受体数：
  1

安全信息

• 危险品标志：
  T
• 安全说明：
  S26,S39,S45
• 危险类别码：
  R25,R41
• WGK Germany：
  3

反应信息

• 作为反应物：
  描述：

  2-甲基-4,5,7-三氯喹啉 在 一水合肼 作用下， 以 乙醇 为溶剂， 以80%的产率得到(5,7-Dichloro-2-methyl-quinolin-4-yl)-hydrazine
  参考文献：
  名称：

  Synthesis and anti-tubercular evaluation of 4-quinolylhydrazones

  摘要：

  A series of 4-quinolylhydrazones were synthesized and tested against Mycobacterium tuberculosis H37Rv. Preparation of the title compounds was achieved by reaction of 4-quinolylhydrazine and aryl- or heteroaryl-carboxaldehyde. For the most of derivatives interesting antitubercular properties were showed: two compounds (3(2) and 3(25)), identified as the most active, were tested also against Mycobacterium avium. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0968-0896(02)00071-8

文献信息

• Synthesis and anti-tubercular evaluation of 4-quinolylhydrazones
  作者：Luisa Savini、Luisa Chiasserini、Alessandra Gaeta、Cesare Pellerano

  DOI：10.1016/s0968-0896(02)00071-8

  日期：2002.7

  A series of 4-quinolylhydrazones were synthesized and tested against Mycobacterium tuberculosis H37Rv. Preparation of the title compounds was achieved by reaction of 4-quinolylhydrazine and aryl- or heteroaryl-carboxaldehyde. For the most of derivatives interesting antitubercular properties were showed: two compounds (3(2) and 3(25)), identified as the most active, were tested also against Mycobacterium avium. (C) 2002 Elsevier Science Ltd. All rights reserved.