2,2-bis-(2,2,2-trifluoro-1,1-bis-trifluoromethyl-ethoxymethyl)-propane-1,3-diol | 929552-51-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2,2-bis-(2,2,2-trifluoro-1,1-bis-trifluoromethyl-ethoxymethyl)-propane-1,3-diol
• 英文别名: 2,2-bis[[1,1,1,3,3,3-hexafluoro-2-(trifluoromethyl)propan-2-yl]oxymethyl]propane-1,3-diol
• CAS: 929552-51-2
• 化学式: C₁₃H₁₀F₁₈O₄
• 分子量: 572.191
• InChiKey: IRWQHKQONWNTNT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  35
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  58.9
• 氢给体数：
  2
• 氢受体数：
  22

反应信息

• 作为反应物：
  描述：

  2,2-bis-(2,2,2-trifluoro-1,1-bis-trifluoromethyl-ethoxymethyl)-propane-1,3-diol 在 ruthenium trichloride 、 sodium periodate 、 氯化亚砜 、 sodium azide 、 jones reagent 、 氢气 、 三乙胺 作用下， 以 甲醇 、 四氯化碳 、 乙醚 、 二氯甲烷 、 水 、 N,N-二甲基甲酰胺 、 乙腈 为溶剂， 反应 37.33h， 生成 3-tert-butoxycarbonylamino-2,2-bis(2,2,2-trifluoro-1,1-bis-trifluoromethylethoxymethyl)propionic acid
  参考文献：
  名称：

  The Synthesis of a Geminally Perfluoro-tert-butylated β-Amino Acid and its Protected Forms as a Potential Pharmacokinetic Modulator and Reporter for Peptide-Based Pharmaceuticals

  摘要：

  To modulate and report the pharmacokinetics of peptide-based pharmaceuticals, a novel geminally perfluoro-tert-butylated beta-amino acid (beta Fa) and its Fmoc- and Boc-protected forms were designed and synthesized. beta Fa was incorporated into a model tripeptide via standard solid-phase chemistry. Both the amino acid (free and protected) and the tripeptide show a sharp singlet F-19 NMR signal. Reversed-phase chromatography and 1-octanol/water partition measurements demonstrate that beta Fa is extremely hydrophobic.

  DOI：

  10.1021/jo0616308
• 作为产物：
  描述：

  2-(4-methoxyphenyl)-5,5-bis(2,2,2-trifluoro-1,1-bis-trifluoromethylethoxymethyl)-[1,3]-dioxane 在 三氯化铝 、 苯甲醚 作用下， 以 二氯甲烷 为溶剂， 以99%的产率得到2,2-bis-(2,2,2-trifluoro-1,1-bis-trifluoromethyl-ethoxymethyl)-propane-1,3-diol
  参考文献：
  名称：

  The Synthesis of a Geminally Perfluoro-tert-butylated β-Amino Acid and its Protected Forms as a Potential Pharmacokinetic Modulator and Reporter for Peptide-Based Pharmaceuticals

  摘要：

  To modulate and report the pharmacokinetics of peptide-based pharmaceuticals, a novel geminally perfluoro-tert-butylated beta-amino acid (beta Fa) and its Fmoc- and Boc-protected forms were designed and synthesized. beta Fa was incorporated into a model tripeptide via standard solid-phase chemistry. Both the amino acid (free and protected) and the tripeptide show a sharp singlet F-19 NMR signal. Reversed-phase chromatography and 1-octanol/water partition measurements demonstrate that beta Fa is extremely hydrophobic.

  DOI：

  10.1021/jo0616308

文献信息

• Highly fluorinated β-amino acids and methods of making and using same
  申请人：University of Utah Foundation

  公开号：US08052961B2

  公开（公告）日：2011-11-08

  Disclosed are compounds having the structure: wherein R1a and R1b are independently H, alkyl, F, or fluoroalkyl; wherein R2a, R2b, R2a′, and R2b′ are independently H, alkyl, F, fluoroalkyl, aryl, or alkenyl; wherein R3 is OH, alkoxyl, NH2, alkylamino, or dialkylamino; wherein R4a and R4b are independently H, alkyl, acyl, or alkyloxycarbonyl; wherein R11, R12, R13, R21, R22, and R23 are independently H, alkyl, F, or fluoroalkyl; and wherein C0, C1, C2 and C2′ are independently chiral or achiral. Also disclosed are processes for making a fluorinated β-amino acid comprising the steps of: providing a diol; treating the diol with a thionyl halide with oxidative workup; reacting the product with an azide salt to yield an azido group; oxidizing the product to yield a carboxyl group; and reducing the azido group to yield an amino group.

  本发明涉及具有以下结构的化合物：其中R1a和R1b独立地为H，烷基，F或氟代烷基；其中R2a，R2b，R2a'和R2b'独立地为H，烷基，F，氟代烷基，芳基或烯基；其中R3为OH，烷氧基，NH2，烷基氨基或二烷基氨基；其中R4a和R4b独立地为H，烷基，酰基或烷氧羰基；其中R11，R12，R13，R21，R22和R23独立地为H，烷基，F或氟代烷基；其中C0，C1，C2和C2'独立地手性或非手性。本发明还涉及制备氟代β-氨基酸的过程，包括以下步骤：提供二醇；用硫酰卤处理二醇并进行氧化工作；将产物与叠氮盐反应以生成叠氮基团；氧化产物以生成羧基团；还原叠氮基团以生成氨基团。
• WO2008/34093
  申请人：——

  公开号：——

  公开（公告）日：——
• HIGHLY FLUORINATED BETA-AMINO ACIDS AND METHODS OF MAKING AND USING SAME
  申请人：Yu Bruce

  公开号：US20090259020A1

  公开（公告）日：2009-10-15

  Disclosed are compounds having the structure: wherein R 1a and R 1b are independently H, alkyl, F, or fluoroalkyl; wherein R 2a , R 2b , R 2a′ , and R 2b′ are independently H, alkyl, F, fluoroalkyl, aryl, or alkenyl; wherein R 3 is OH, alkoxyl, NH 2 , alkylamino, or dialkylamino; wherein R 4a and R 4b are independently H, alkyl, acyl, or alkyloxycarbonyl; wherein R 11 , R 12 , R 13 , R 21 , R 22 , and R 23 are independently H, alkyl, F, or fluoroalkyl; and wherein C0, C1, C2, and C2′ are independently chiral or achiral. Also disclosed are processes for making a fluorinated β-amino acid comprising the steps of: providing a diol; treating the diol with a thionyl halide with oxidative workup; reacting the product with an azide salt to yield an azido group; oxidizing the product to yield a carboxyl group; and reducing the azido group to yield an amino group. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
• US8052961B2
  申请人：——

  公开号：US8052961B2

  公开（公告）日：2011-11-08
• [EN] HIGHLY FLUORINATED ß-AMINO ACIDS AND METHODS OF MAKING AND USING SAME<br/>[FR] ß-AMINOACIDES HAUTEMENT FLUORÉS, ET LEURS PROCÉDÉS DE FABRICATION ET D'UTILISATION
  申请人：UNIV UTAH RES FOUND

  公开号：WO2008034093A2

  公开（公告）日：2008-03-20

  [EN] Disclosed are compounds having the structure: wherein R^la and R^lb are independently H, alkyl, F, or fluoroalkyl; wherein R^2a, R^2b, R^2a', and R^2b are independently H, alkyl, F, fluoroalkyl, aryl, or alkenyl; wherein R³ is OH, alkoxyl, NH₂, alkylamino, or dialkylamino; wherein R^4a and R^4b are independently H, alkyl, acyl, or alkyloxycarbonyl; wherein R₁₁, R₁₂, R₁₃, R₂₁, R₂₂, and R₂₃ are independently H, alkyl, F, or fluoroalkyl; and wherein CO, Cl, C2, and C2' are independently chiral or achiral. Also disclosed are processes for making a fluorinated ß-amino acid comprising the steps of: providing a diol; treating the diol with a thionyl halide with oxidative workup; reacting the product with an azide salt to yield an azido group; oxidizing the product to yield a carboxyl group; and reducing the azido group to yield an amino group. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
  [FR] L'invention concerne des composés présentant la structure : dans laquelle R^la et R^lb sont indépendamment H, alkyle, F ou fluoroalkyle ; R^2a, R^2b, R^2a' et R^2b sont indépendamment H, alkyle, F, fluoroalkyle, aryle ou alcényle ; R³ est OH, alkoxyle, NH₂, alkylamino ou dialkylamino ; R^4a et R^4b sont indépendamment H, alkyle, acyle ou alkyloxycarbonyle ; R₁₁, R₁₂, R₁₃, R₂₁, R₂₂ et R₂₃ sont indépendamment H, alkyle, F ou fluoroalkyle ; et CO, Cl, C2 et C2' sont indépendamment chiral ou achiral. L'invention concerne également des procédés destinés à fabriquer un ß-aminoacide fluoré comprenant les étapes consistant à : fournir un diol ; traiter le diol avec un halogénure de thionyle avec traitement final d'oxydation ; faire réagir le produit avec un sel d'azide afin de produire un groupe azido ; oxyder le produit afin de produire un groupe carboxyle ; et réduire le groupe azido afin de produire un groupe amino. Le présent abrégé est destiné à servir d'outil pour permettre une recherche dans le domaine spécifique concerné, et n'a pas pour objet de limiter la portée de l'invention.