(1S,3R,6R,7R)-4-Isopropylidene-1-methyl-7-[2-(2-methyl-[1,3]dioxolan-2-yl)-ethyl]-bicyclo[4.1.0]heptan-3-ol | 213544-75-3

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: (1S,3R,6R,7R)-4-Isopropylidene-1-methyl-7-[2-(2-methyl-[1,3]dioxolan-2-yl)-ethyl]-bicyclo[4.1.0]heptan-3-ol
• 英文别名: (1S,3R,6R,7R)-1-methyl-7-[2-(2-methyl-1,3-dioxolan-2-yl)ethyl]-4-propan-2-ylidenebicyclo[4.1.0]heptan-3-ol
• CAS: 213544-75-3
• 化学式: C₁₇H₂₈O₃
• 分子量: 280.408
• InChiKey: FGTOUYKVTMCWLV-FPCVCCKLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  38.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (1S,3R,6R,7R)-4-Isopropylidene-1-methyl-7-[2-(2-methyl-[1,3]dioxolan-2-yl)-ethyl]-bicyclo[4.1.0]heptan-3-ol 在 sodium hydroxide 、 硼烷四氢呋喃络合物 、 双氧水 、 对甲苯磺酸 作用下， 以 四氢呋喃 、 1,4-二氧六环 、 水 为溶剂， 反应 7.0h， 生成 (1S,6R,7R)-7-(3-Hydroxy-butyl)-4-(1-hydroxy-1-methyl-ethyl)-1-methyl-bicyclo[4.1.0]heptan-3-ol
  参考文献：
  名称：

  Absolute stereostructure of carabrane-type sesquiterpene and vasorelaxant-active sesquiterpenes from Zedoariae Rhizoma

  摘要：

  The aqueous acetone extract of Zedoariae Rhizoma was found to show inhibitory effects on contractions induced by high concentrations of potassium cation (K+) in isolated rat aortic strips. From the extract, two new carabrane-type sesquiterpenes, curcarabranols A and B, were isolated together with a few carabrane-type sesquiterpenes, such as curcumenone and 4S-dihydrocurcumenone. Their absolute stereostructures were determined on the basis of chemical and physicochemical evidence, which included the application of the modified Mosher's method and chemical conversion from curcumenone to curcarabranols A and B. In addition, several sesquiterpenes and diaryl-heptanoids (e.g. germacrone, glechomanolide, isocurucmenol, beta -eudesmol, and beta -dictyopterol) showed potent inhibitory effects on contractions induced by high concentrations of K+ in isolated rat aortic strips (inhibition > 80% at 100 muM), while they did not inhibit norepinephrine-induced contractions, so that the vasorelaxant activities of these sesquiterpenes were presumed to be dependent on their calcium channel-blocking activity. (C) 2001 Elsevier Science Ltd. AE rights reserved.

  DOI：

  10.1016/s0040-4020(01)00828-6
• 作为产物：
  描述：

  (1S,6R,7R)-1-甲基-7-(3-氧代丁基)-4-丙-2-亚基双环[4.1.0]庚烷-3-酮 在 sodium tetrahydroborate 、 三氟甲磺酸三甲基硅酯 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 生成 (1S,3R,6R,7R)-4-Isopropylidene-1-methyl-7-[2-(2-methyl-[1,3]dioxolan-2-yl)-ethyl]-bicyclo[4.1.0]heptan-3-ol
  参考文献：
  名称：

  Absolute Stereostructures of Carabrane-Type Sesquiterpenes, Curcumenone, 4S-Dihydrocurcumenone, and Curcarabranols A and B: Vasorelaxant Activity of Zedoary Sesquiterpenes.

  摘要：

  从莪术中分离出了新的莪术酚 A 和 B，以及两种已知的莪术酮和 4S- 二氢莪术酮。根据物理化学和化学证据确定了这些石榴烯类倍半萜的绝对立体结构。研究发现，包括 4S- 二氢莪术酮和莪术醇 A 和 B 在内的泽泻烯类倍半萜能抑制高浓度 K+ 在离体大鼠主动脉条带上引起的收缩。

  DOI：

  10.1248/cpb.46.1186

文献信息

• Absolute Stereostructures of Carabrane-Type Sesquiterpenes, Curcumenone, 4S-Dihydrocurcumenone, and Curcarabranols A and B: Vasorelaxant Activity of Zedoary Sesquiterpenes.
  作者：Masayuki YOSHIKAWA、Toshiyuki MURAKAMI、Toshio MORIKAWA、Hisashi MATSUDA

  DOI：10.1248/cpb.46.1186

  日期：——

  New carabrane-type sesquiterpenes, curcarabranols A and B, were isolated from zedoary together with the two known carabrane-type sesquiterpenes curcumenone and 4S-dihydrocurcumenone. The absolute stereostructures of these carabrane-type sesquiterpenes were determined on the basis of physicochemical and chemical evidence. Zedoary sesquiterpenes including 4S-dihydrocurcumenone and curcarabranols A and B were found to inhibit the contraction induced by a high concentration of K+ in isolated rat aortic strips.

  从莪术中分离出了新的莪术酚 A 和 B，以及两种已知的莪术酮和 4S- 二氢莪术酮。根据物理化学和化学证据确定了这些石榴烯类倍半萜的绝对立体结构。研究发现，包括 4S- 二氢莪术酮和莪术醇 A 和 B 在内的泽泻烯类倍半萜能抑制高浓度 K+ 在离体大鼠主动脉条带上引起的收缩。
• Absolute stereostructure of carabrane-type sesquiterpene and vasorelaxant-active sesquiterpenes from Zedoariae Rhizoma
  作者：Hisashi Matsuda、Toshio Morikawa、Kiyofumi Ninomiya、Masayuki Yoshikawa

  DOI：10.1016/s0040-4020(01)00828-6

  日期：2001.10

  The aqueous acetone extract of Zedoariae Rhizoma was found to show inhibitory effects on contractions induced by high concentrations of potassium cation (K+) in isolated rat aortic strips. From the extract, two new carabrane-type sesquiterpenes, curcarabranols A and B, were isolated together with a few carabrane-type sesquiterpenes, such as curcumenone and 4S-dihydrocurcumenone. Their absolute stereostructures were determined on the basis of chemical and physicochemical evidence, which included the application of the modified Mosher's method and chemical conversion from curcumenone to curcarabranols A and B. In addition, several sesquiterpenes and diaryl-heptanoids (e.g. germacrone, glechomanolide, isocurucmenol, beta -eudesmol, and beta -dictyopterol) showed potent inhibitory effects on contractions induced by high concentrations of K+ in isolated rat aortic strips (inhibition > 80% at 100 muM), while they did not inhibit norepinephrine-induced contractions, so that the vasorelaxant activities of these sesquiterpenes were presumed to be dependent on their calcium channel-blocking activity. (C) 2001 Elsevier Science Ltd. AE rights reserved.