triptoquinone D | 142937-48-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: triptoquinone D
• 英文别名: (4bS,8S,8aR)-8-(hydroxymethyl)-4b,8-dimethyl-2-propan-2-yl-5,6,7,8a,9,10-hexahydrophenanthrene-1,4-dione
• CAS: 142937-48-2
• 化学式: C₂₀H₂₈O₃
• 分子量: 316.441
• InChiKey: DRLOWVKWHPVIMW-DBVUQKKJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  23
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  54.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  triptoquinone D 在 重铬酸吡啶 作用下， 以 乙醚 、 二氯甲烷 为溶剂， 反应 0.33h， 以56%的产率得到triptoquinone E
  参考文献：
  名称：

  Tripterygium wilfordii var. regelii which are interleukin-1 inhibitors

  摘要：

  Seven new quinoide-type diterpenes were isolated from the stems of Tripterygium wilfordii var. regelii and their structures were established on the basis of spectroscopic and chemical evidence. The isolated compounds showed extremely potent inhibitory activities against interleukin-1 alpha and beta releases for human peripheral mononuclear cells.

  DOI：

  10.1016/s0031-9422(00)90596-x
• 作为产物：
  描述：

  (1S,4aS,10aR)-7-Isopropyl-5,8-dimethoxy-1,4a-dimethyl-1,2,3,4,4a,9,10,10a-octahydro-phenanthrene-1-carboxylic acid methyl ester 在 lithium aluminium tetrahydride 、 ammonium cerium(IV) nitrate 作用下， 以 四氢呋喃 、 水 、 乙腈 为溶剂， 反应 0.75h， 生成 triptoquinone D
  参考文献：
  名称：

  Tripterygium wilfordii var. regelii which are interleukin-1 inhibitors

  摘要：

  Seven new quinoide-type diterpenes were isolated from the stems of Tripterygium wilfordii var. regelii and their structures were established on the basis of spectroscopic and chemical evidence. The isolated compounds showed extremely potent inhibitory activities against interleukin-1 alpha and beta releases for human peripheral mononuclear cells.

  DOI：

  10.1016/s0031-9422(00)90596-x

文献信息

• Tripterygium wilfordii var. regelii which are interleukin-1 inhibitors
  作者：Kozo Shishido、Kimiko Nakano、Noriko Wariishi、Hideo Tateishi、Tomoki Omodani、Masayuki Shibuya、Kiyoto Goto、Yukihisa Ono、Yoshihisa Takaishi

  DOI：10.1016/s0031-9422(00)90596-x

  日期：1994.2

  Seven new quinoide-type diterpenes were isolated from the stems of Tripterygium wilfordii var. regelii and their structures were established on the basis of spectroscopic and chemical evidence. The isolated compounds showed extremely potent inhibitory activities against interleukin-1 alpha and beta releases for human peripheral mononuclear cells.