3,5-diacetoxy-4-isopropylbenzoic acid | 1015065-16-3

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 3,5-diacetoxy-4-isopropylbenzoic acid
• 英文别名: 3,5-diacetyloxy-4-propan-2-ylbenzoic acid
• CAS: 1015065-16-3
• 化学式: C₁₄H₁₆O₆
• 分子量: 280.277
• InChiKey: YNTOBEJXBGNAAZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  20
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  89.9
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  6-amino-4-(2,4-dimethoxyphenyl)-4H,5H-[1,2]dithiolo[4,3-b]pyrrol-5-one hydrochloride 、 3,5-diacetoxy-4-isopropylbenzoic acid 在 N,N'-二环己基碳二亚胺 作用下， 以 二氯甲烷 为溶剂， 反应 2.0h， 生成
  参考文献：
  名称：

  WO2008/38175

  摘要：

  公开号：
• 作为产物：
  描述：

  3,5-Dihydroxy-4-isopropylbenzoic acid triethylamine salt 在 盐酸 、 乙酸酐 、 三乙胺 作用下， 生成 3,5-diacetoxy-4-isopropylbenzoic acid
  参考文献：
  名称：

  ISOQUINOLINE COMPOUNDS AND THEIR USE IN TREATING AhR IMBALANCE

  摘要：

  本发明涉及式（I）的新化合物，或其药学上可接受的盐、溶剂合物或水合物。还描述了包含式（I）的化合物，或其药学上可接受的盐、溶剂合物或水合物的药物组合物。该发明还涉及使用式（I）的化合物治疗与AhR失衡相关的哺乳动物病症，如炎症性疾病或紊乱。

  公开号：

  US20220017468A1

文献信息

• Isoquinoline compounds and their use in treating AhR imbalance
  申请人：Dermavant Sciences GmbH

  公开号：US11267788B2

  公开（公告）日：2022-03-08

  The present invention is directed to novel compounds of Formula (I), or a pharmaceutically acceptable salt, solvate or hydrate thereof. Pharmaceutical compositions comprising a compound of Formula (I), or a pharmaceutically acceptable salt, solvate or hydrate thereof, are also described. The invention is also directed to use of the compounds of Formula (I) for treating a condition in a mammal associated with AhR imbalance, such as an inflammatory disease or disorder.

  本发明涉及式（I）的新型化合物或其药学上可接受的盐、溶液或水合物。本发明还描述了包含式（I）化合物或其药学上可接受的盐、溶液或水合物的药物组合物。本发明还涉及式（I）化合物用于治疗哺乳动物体内与 AhR 失衡有关的疾病，如炎症性疾病或紊乱。
• DITHIOLOPYRROLONE DERIVATIVES USEFUL IN THE TREATMENT OF PROLIFERATIVE DISEASES
  申请人：Welichem Biotech Inc.

  公开号：EP1490374A2

  公开（公告）日：2004-12-29
• NOVEL DITHIOLOPYRROLONES AND THEIR THERAPEUTICAL APPLICATIONS
  申请人：Celestial Pharmaceuticals (Shenzhen) LTD.

  公开号：EP2076519A2

  公开（公告）日：2009-07-08
• Novel dithiolopyrrolones with therapeutic activity
  申请人：Chen Genhui

  公开号：US20060074125A1

  公开（公告）日：2006-04-06

  The present invention provides novel dithiolopyrrolone compounds and their salts, which are useful as treatments for cancer and other proliferative diseases. The present invention also provides therapeutic compositions comprising particularly useful types of dithiolopyrrolones, the salts thereof, and methods of using the compounds within such types, particularly in treating proliferative diseases such as cancer.
• DITHIOLOPYRROLONES COMPOUNDS AND THEIR THERAPEUTIC APPLICATIONS
  申请人：Guo Yingping

  公开号：US20100041729A1

  公开（公告）日：2010-02-18

  The present invention provides dithiolopyrrolone compounds of the general formula I, and their salts, wherein A is sulfur or carbon, and R 1 , R 2 , and R 3 are selected from groups defined herein, and wherein when A is sulfur, then B is oxygen, and n=1 or 2, and when A is carbon, then B is oxygen or sulfur, and n=1. The compounds are useful for the prevention and treatment of microbial infections such as HIV infection, and for the treatment of blood disorders, such as neutropenia. In particular, the compounds are useful for the manufacture of medicaments for increasing white blood cells.