7-deacetylgedunin

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 7-deacetylgedunin
• 英文别名: 7-deacetoxy-7α-hydroxygedunin；(1S,2R,4S,7S,8S,12R,19R)-7-(furan-3-yl)-19-hydroxy-1,8,12,16,16-pentamethyl-3,6-dioxapentacyclo[9.8.0.02,4.02,8.012,17]nonadec-13-ene-5,15-dione
• 化学式: C₂₆H₃₂O₆
• 分子量: 440.536
• InChiKey: HCEYJYMNIQHPPK-NIANHESQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  32
• 可旋转键数：
  1
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.69
• 拓扑面积：
  89.3
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  7-deacetylgedunin 在 盐酸 、 溶剂黄146 作用下， 反应 4.0h， 以47%的产率得到7-deacetoxy-7,9-diene-15β-hydroxygedunin
  参考文献：
  名称：

  前所未有的葛根素重排反应将甲基转化为环丙基环的亚甲基

  摘要：

  本文中，我们描述了通过未经目的而官能化的甲基的转化，空前形成环丙烷环。在一个一步反应中，7-脱乙酰氧基-7α-羟基葛根素（4）提供了两个新的葛根素衍生物，即7-脱乙酰氧基-13,14,18-环丙基-7α，15β，17ξ-三羟基-gedu-16-oic酸（7）和7-脱乙酰氧基-9,11-en-7α，15β-二羟基葛根宁（8）以及已知的7-脱乙酰氧基-7,9-二烯-15β-羟基葛根宁（5）。

  DOI：

  10.1016/j.tet.2014.06.067
• 作为产物：
  描述：

  7-deacetoxy-7-oxogedunin 在 sodium tetrahydroborate 作用下， 以 四氢呋喃 为溶剂， 反应 0.25h， 以72%的产率得到7-epi-deacetylgedunin
  参考文献：
  名称：

  Kehrli, Anne R. H.; Taylor, David A. H.; Niven, Margaret, Journal of the Chemical Society. Perkin transactions I, 1990, # 7, p. 2057 - 2065

  摘要：

  DOI：

文献信息

• Compositions and methods for neuroprotectin
  申请人：Steiner P. Joseph

  公开号：US20080090897A1

  公开（公告）日：2008-04-17

  Disclosed herein are neuroprotective compounds. Methods for the preparation of such compounds are disclosed. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the compounds disclosed, alone or in combination with other therapeutic agents, for the treatment of neurodegenerative conditions are provided.
• Role of limonoid compounds as neuroprotective agents
  申请人：Steiner Joseph P.

  公开号：US20100056617A1

  公开（公告）日：2010-03-04

  Disclosed herein are neuroprotective compounds. Methods for the preparation of such compounds are disclosed. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the compounds disclosed, alone or in combination with other therapeutic agents, for the treatment of neurodegenerative conditions are provided.
• Methods and Compositions for Diagnosis and Treatment of Multiple Sclerosis
  申请人：Nath Avindra

  公开号：US20100137420A1

  公开（公告）日：2010-06-03

  Biological markers for multiple sclerosis, and their use in the diagnosis and prognosis of the disease, are described. Also described are methods for treating multiple sclerosis by administering an inhibitor of cathepsin B activity or a neuroprotective composition comprising a modified terpenoid compound. Also described are isolated polypeptide biomarkers, polynucleotides encoding the polypeptide biomarkers, and antibodies that bind specifically to the polypeptide biomarkers. Further described are kits that include the above-mentioned isolated polypeptide biomarkers, the polynucleotides encoding them, or specific antibodies against the polypeptide biomarkers.
• COMPOUNDS AND METHODS FOR MODULATING PROTEIN TRAFFICKING
  申请人：Bulawa Christine

  公开号：US20100305068A1

  公开（公告）日：2010-12-02

  Disclosed are compositions and methods for modulating protein trafficking and treating or preventing disorders characterized by impaired protein trafficking. Also disclosed are methods for producing a protein and identifying compounds that rescue protein trafficking defects.
• US8114619B2
  申请人：——

  公开号：US8114619B2

  公开（公告）日：2012-02-14