kuwanon H | 76472-87-2

• 物质功能分类: 生物化工 - 提取物 - 植物提取物
• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: kuwanon H
• 英文别名: moracenin A；8-[6-[2,4-dihydroxy-3-(3-methylbut-2-enyl)benzoyl]-5-(2,4-dihydroxyphenyl)-3-methylcyclohex-2-en-1-yl]-2-(2,4-dihydroxyphenyl)-5,7-dihydroxy-3-(3-methylbut-2-enyl)chromen-4-one
• CAS: 76472-87-2
• 化学式: C₄₅H₄₄O₁₁
• 分子量: 760.838
• InChiKey: DKBPTKFKCCNXNH-UHFFFAOYSA-N

物化性质

• 溶解度：
  溶于二甲基亚砜

计算性质

• 辛醇/水分配系数(LogP)：
  9.2
• 重原子数：
  56
• 可旋转键数：
  9
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  205
• 氢给体数：
  8
• 氢受体数：
  11

制备方法与用途

生物活性

Kuwanon H 是桑白皮中的一种黄酮类化合物，是非肽类蛙皮素受体（bombesin receptor）拮抗剂。它能够特异性地抑制细胞内胃泌激素释放肽 CRP 与(GRP-preferring receptor) 受体的结合，Ki 值为 290 nM。

靶点

• Ki: 290 nM (GRP-preferring receptor)

反应信息

• 作为反应物：
  描述：

  kuwanon H 、 硫酸二甲酯 以 丙酮 为溶剂， 生成 2-(2,4-Dimethoxy-phenyl)-8-{5-(2,4-dimethoxy-phenyl)-6-[2-hydroxy-4-methoxy-3-(3-methyl-but-2-enyl)-benzoyl]-3-methyl-cyclohex-2-enyl}-5-hydroxy-7-methoxy-3-(3-methyl-but-2-enyl)-chromen-4-one 、 8-[6-[2,4-Dimethoxy-3-(3-methyl-but-2-enyl)-benzoyl]-5-(2,4-dimethoxy-phenyl)-3-methyl-cyclohex-2-enyl]-2-(2,4-dimethoxy-phenyl)-5,7-dimethoxy-3-(3-methyl-but-2-enyl)-chromen-4-one
  参考文献：
  名称：

  Nomura, Taro; Fukai, Toshio, Heterocycles, 1980, vol. 14, # 12, p. 1943 - 1951

  摘要：

  DOI：

文献信息

• Compositions and methods for joint health
  申请人：Unigen, Inc.

  公开号：US11123393B2

  公开（公告）日：2021-09-21

  The present disclosure provides mixtures of prenylated flavonoids, stilbenes, or both with flavans or curcuminoids or both capable of modulating joint inflammation, joint pain, joint stiffness, cartilage degradation, or improving mobility, range of motion, flexibility, joint physical function, or any combination thereof. Such a mixture of prenylated flavonoids, stilbenes, or both with flavans or curcuminoids or both can optionally be used in combination with other joint management agents, such as non-steroidal anti-inflammatory agents/analgesics, COX/LOX inhibiting agents, glucosamine compounds, neuropathic pain relief agents, or the like.

  本公开提供了前炔类黄酮、二苯乙烯类化合物或二者与黄烷或姜黄素或二者的混合物，能够调节关节炎症、关节疼痛、关节僵硬、软骨退化，或改善活动能力、活动范围、柔韧性、关节物理功能或其任意组合。这种前炔类黄酮、二苯乙烯类化合物或二者与黄烷或姜黄素或二者的混合物可以选择性地与其他关节调理剂结合使用，如非甾体抗炎剂/镇痛剂、COX/LOX 抑制剂、氨基葡萄糖化合物、神经性疼痛缓解剂等。
• ANTI-BACTERIAL USE OF EXTRACT FROM MORUS AUSTRALIS POIR. AND COMPOUND KUWANON H
  申请人：Ku Yuan-Ling

  公开号：US20100166898A1

  公开（公告）日：2010-07-01

  An extract prepared from the root barks of Morus australis Poir. and its use as an anti-bacteria agent, and use of a compound Kuwanon H having the following formula (I) separated from the extract as an anti-bacteria agent:
• COMPOSITIONS AND METHODS FOR JOINT HEALTH
  申请人：Unigen, Inc.

  公开号：US20150072953A1

  公开（公告）日：2015-03-12

  The present disclosure provides mixtures of prenylated flavonoids, stilbenes, or both with flavans or curcuminoids or both capable of modulating joint inflammation, joint pain, joint stiffness, cartilage degradation, or improving mobility, range of motion, flexibility, joint physical function, or any combination thereof. Such a mixture of prenylated flavonoids, stilbenes, or both with flavans or curcuminoids or both can optionally be used in combination with other joint management agents, such as non-steroidal anti-inflammatory agents/analgesics, COX/LOX inhibiting agents, glucosamine compounds, neuropathic pain relief agents, or the like.
• COMPOSITIONS AND METHODS FOR MANAGING OR IMPROVING BONE DISORDERS, CARTILAGE DISORDERS, OR BOTH
  申请人：Unigen, Inc.

  公开号：US20160045559A1

  公开（公告）日：2016-02-18

  The present disclosure provides mixtures of prenylated flavonoids, stilbenes, or both with flavans or curcuminoids or both capable of useful for promoting, managing or improving bone health, cartilage health or both, or for preventing or treating a bone disorder, cartilage disorder or both. Such a mixture of prenylated flavonoids, stilbenes, or both with flavans or curcuminoids or both can optionally be used in combination with other bone and cartilage management agents, such as calcium, magnesium, zinc, boron, vitamin D, vitamin K, glucosamine and/or chondroitin compounds, non-steroidal anti-inflammatory agents/analgesics, COX/LOX inhibiting agents, neuropathic pain relief agents, or the like.
• Compositions and Methods for Joint Health
  申请人：Unigen, Inc.

  公开号：US20160067296A1

  公开（公告）日：2016-03-10

  The present disclosure provides mixtures of prenylated flavonoids, stilbenes, or both with flavans or curcuminoids or both capable of modulating joint inflammation, joint pain, joint stiffness, cartilage degradation, or improving mobility, range of motion, flexibility, joint physical function, or any combination thereof. Such a mixture of prenylated flavonoids, stilbenes, or both with flavans or curcuminoids or both can optionally be used in combination with other joint management agents, such as non-steroidal anti-inflammatory agents/analgesics, COX/LOX inhibiting agents, glucosamine compounds, neuropathic pain relief agents, or the like.