(2E)-3-(furan-2-yl)-N-{[3-methoxy-4-(2-oxo-2H-chromen-3-yl)phenyl]carbamothioyl}prop-2-enamide

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 异黄酮类化合物
• 英文名称: (2E)-3-(furan-2-yl)-N-{[3-methoxy-4-(2-oxo-2H-chromen-3-yl)phenyl]carbamothioyl}prop-2-enamide
• 英文别名: (E)-3-(furan-2-yl)-N-[[3-methoxy-4-(2-oxochromen-3-yl)phenyl]carbamothioyl]prop-2-enamide
• 化学式: C₂₄H₁₈N₂O₅S
• 分子量: 446.5
• InChiKey: MVDIOKUKBCLDHE-PKNBQFBNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  32
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.04
• 拓扑面积：
  122
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  3-(4-Amino-2-methoxy-phenyl)-chromen-2-one 、 trans-3-(2-furyl)propenoyl isothiocyanate 在 乙醇 作用下， 以 二氯甲烷 为溶剂， 反应 2.5h， 以to yield 2.6 g of a yellow powder (mp 227-230° C.)的产率得到(2E)-3-(furan-2-yl)-N-{[3-methoxy-4-(2-oxo-2H-chromen-3-yl)phenyl]carbamothioyl}prop-2-enamide
  参考文献：
  名称：

  ANTI-PROLIFERATIVE COMPOUNDS FROM A 3-ARYL-COUMARINE OR 3-ARYL-QUINOLIN-2-ONE AND USES THEREOF

  摘要：

  本发明涉及源自3-芳基香豆素或3-芳基喹啉-2-酮的分子，具有强大的抗增殖和/或细胞毒性活性，特别是对肿瘤细胞。本发明还涉及这些分子在治疗应用中的用途，用于治疗不同的癌症。本发明还揭示了使用该化合物制造用于治疗癌症的药物的用途。本发明还涉及一种抑制细胞增殖的方法，包括将所述细胞与本发明的化合物接触。

  公开号：

  US20090203685A1

文献信息

• Anti-proliferative compounds deriving from a 3-aryl-coumarine or 3-aryl-quinolin-2-one and uses thereof
  申请人：Aptanomics

  公开号：EP1860104A1

  公开（公告）日：2007-11-28

  The present invention is directed to molecules deriving from a 3-aryl-coumarine or 3-aryl-quinolin-2-one and having potent anti-proliferative and/ or cytotoxic activity, especially against tumoral cells. The present invention also concerns the uses of these molecules in therapeutic application, for the treatment of different cancers. The invention also discloses the use of said compound for the manufacture of a medicament for treating cancer. The invention also concerns a process for inhibiting cell proliferation comprising contacting said cells with a compound of the invention.

  本发明涉及由 3-芳基香豆素或 3-芳基喹啉-2-酮衍生的分子，这些分子具有强效的抗增殖和/或细胞毒性活性，特别是对肿瘤细胞的活性。本发明还涉及这些分子在治疗不同癌症方面的应用。本发明还公开了上述化合物用于制造治疗癌症的药物。本发明还涉及一种抑制细胞增殖的工艺，包括将所述细胞与本发明的化合物接触。
• ANTI-PROLIFERATIVE COMPOUNDS DERIVING FROM A 3-ARYL-COUMARINE OR 3-ARYL-QUINOLIN-2-ONE AND USES THEREOF
  申请人：EOS - Ethical Oncology Science S.p.A.

  公开号：EP2021333A2

  公开（公告）日：2009-02-11
• [EN] ANTI-PROLIFERATIVE COMPOUNDS DERIVING FROM A 3-ARYL-COUMARINE OR 3-ARYL-QUINOLIN-2-ONE AND USES THEREOF<br/>[FR] COMPOSÉS ANTIPROLIFÉRANTS DÉRIVÉS D'UNE 3-ARYL-COUMARINE OU D'UNE 3-ARYL-QUINOLÉIN-2-ONE ET LEURS APPLICATIONS
  申请人：APTANOMICS

  公开号：WO2007135565A2

  公开（公告）日：2007-11-29

  [EN] The present invention is directed to molecules deriving from a 3-aryl-coumarine or 3-aryl-quinolin- 2-one and having potent anti-proliferative and/ or cytotoxic activity, especially against tumoral cells. The present invention also concerns the uses of these molecules in therapeutic application, for the treatment of different cancers. The invention also discloses the use of said compound for the manufacture of a medicament for treating cancer. The invention also concerns a process for inhibiting cell proliferation comprising contacting said cells with a compound of the invention.
  [FR] La présente invention concerne des molécules dérivées d'une 3-aryl-coumarine ou d'une 3-aryl-quinoléin-2-one et présentant une puissante activité antiproliférante et/ou cytotoxique, en particulier contre les cellules tumorales. La présente invention concerne également les applications de ces molécules en thérapie dans le traitement de différents cancers. La présente invention concerne en outre l'application desdits composés à la fabrication d'un médicament destiné au traitement du cancer. La présente invention concerne également un procédé d'inhibition de la prolifération cellulaire qui implique la mise en contact desdites cellules avec un composé selon l'invention.
• ANTI-PROLIFERATIVE COMPOUNDS FROM A 3-ARYL-COUMARINE OR 3-ARYL-QUINOLIN-2-ONE AND USES THEREOF
  申请人：Schapira Matthieu

  公开号：US20090203685A1

  公开（公告）日：2009-08-13

  The present invention is directed to molecules deriving from a 3-aryl-coumarine or 3-aryl-quinolin-2-one and having potent anti-proliferative and/or cytotoxic activity, especially against tumoral cells. The present invention also concerns the uses of these molecules in therapeutic application, for the treatment of different cancers. The invention also discloses the use of said compound for the manufacture of a medicament for treating cancer. The invention also concerns a process for inhibiting cell proliferation comprising contacting said cells with a compound of the invention.

  本发明涉及源自3-芳基香豆素或3-芳基喹啉-2-酮的分子，具有强大的抗增殖和/或细胞毒性活性，特别是对肿瘤细胞。本发明还涉及这些分子在治疗应用中的用途，用于治疗不同的癌症。本发明还揭示了使用该化合物制造用于治疗癌症的药物的用途。本发明还涉及一种抑制细胞增殖的方法，包括将所述细胞与本发明的化合物接触。