6α-hydroxy-3-oxo-pinguis-5(10)-ene-11,6-olide | 178062-56-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 6α-hydroxy-3-oxo-pinguis-5(10)-ene-11,6-olide
• 英文别名: (4R,4aS,7R,7aS,8aR)-8a-hydroxy-4,4a,7,7a-tetramethyl-4,6,7,8-tetrahydrocyclopenta[f][1]benzofuran-2,5-dione
• CAS: 178062-56-1
• 化学式: C₁₅H₂₀O₄
• 分子量: 264.321
• InChiKey: SOKIRSKBDFGHPD-DPQXWDTRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  19
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.73
• 拓扑面积：
  63.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  6α-hydroxy-3-oxo-pinguis-5(10)-ene-11,6-olide 在 potassium carbonate 作用下， 以 丙酮 为溶剂， 反应 3.0h， 以1.8 mg的产率得到3-oxo-pinguis-5(10),6-diene-11,6-olide
  参考文献：
  名称：

  Pinguisone derivatives from an axenic culture of the liverwort Aneura pinguis

  摘要：

  Three new pinguisane-type sesquiterpenes, 6 alpha-hydroxy-3-oxo-pinguis-5(10)-ene-11,6-olide, 6 alpha-methoxy-3-oxo-pinguis-5(10)-ene-11,6-olide and 3-oxo-pinguis-5(10),6-diene-11,6-olide, together with pinguisone, have been isolated from axenic culture of the liverwort, Aneura pinguis. Their structures and relative stereochemistry were elucidated on the basis of spectroscopic evidence and chemical transformation.

  DOI：

  10.1016/0031-9422(95)00971-x
• 作为产物：
  描述：

  (4R)-4,4a,6,7,7a,8-六氢-4beta,4abeta,7beta,7abeta-四甲基-5H-茚并[5,6-b]呋喃-5-酮 在 间氯过氧苯甲酸 作用下， 以 二氯甲烷 为溶剂， 反应 1.0h， 以3.0 mg的产率得到6α-hydroxy-3-oxo-pinguis-5(10)-ene-11,6-olide
  参考文献：
  名称：

  Pinguisone derivatives from an axenic culture of the liverwort Aneura pinguis

  摘要：

  Three new pinguisane-type sesquiterpenes, 6 alpha-hydroxy-3-oxo-pinguis-5(10)-ene-11,6-olide, 6 alpha-methoxy-3-oxo-pinguis-5(10)-ene-11,6-olide and 3-oxo-pinguis-5(10),6-diene-11,6-olide, together with pinguisone, have been isolated from axenic culture of the liverwort, Aneura pinguis. Their structures and relative stereochemistry were elucidated on the basis of spectroscopic evidence and chemical transformation.

  DOI：

  10.1016/0031-9422(95)00971-x

文献信息

• Pinguisone derivatives from an axenic culture of the liverwort Aneura pinguis
  作者：Hiroyuki Tazaki、Hiroshi Soutome、Kensuke Nabeta、Hiroshi Okuyama、Hans Becker

  DOI：10.1016/0031-9422(95)00971-x

  日期：1996.5

  Three new pinguisane-type sesquiterpenes, 6 alpha-hydroxy-3-oxo-pinguis-5(10)-ene-11,6-olide, 6 alpha-methoxy-3-oxo-pinguis-5(10)-ene-11,6-olide and 3-oxo-pinguis-5(10),6-diene-11,6-olide, together with pinguisone, have been isolated from axenic culture of the liverwort, Aneura pinguis. Their structures and relative stereochemistry were elucidated on the basis of spectroscopic evidence and chemical transformation.