(S)-N-methylstylopine | 113349-14-7

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 原小檗碱生物碱及其衍生物
• 英文名称: (S)-N-methylstylopine
• 英文别名: N-methylstylopine；(1S,13S)-13-methyl-5,7,17,19-tetraoxa-13-azoniahexacyclo[11.11.0.02,10.04,8.015,23.016,20]tetracosa-2,4(8),9,15(23),16(20),21-hexaene
• CAS: 113349-14-7
• 化学式: C₂₀H₂₀NO₄
• 分子量: 338.383
• InChiKey: GBUUKFRQPCPYPW-KKSFZXQISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  25
• 可旋转键数：
  0
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  36.9
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (S)-N-methylstylopine 在 氧气 、 还原型辅酶II(NADPH)四钠盐 作用下， 反应 0.33h， 生成 原阿片碱
  参考文献：
  名称：

  Enzymatic formation of protopines by a microsomal cytochrome P-450 system of

  摘要：

  DOI：

  10.1016/s0040-4039(00)96715-7

文献信息

• Benzylisoquinoline alkaloids (BIA) producing microbes, and methods of making and using the same
  申请人：The Board of Trustees of the Leland Stanford Junior University

  公开号：US10017799B2

  公开（公告）日：2018-07-10

  Aspects of the invention include host cells that are engineered to produce benzylisoquinoline alkaloids (BIAs). The host cells include heterologous coding sequences for a variety of enzymes involved in synthetic pathways from starting compounds to BIAs of the host cell. Also provided are methods of producing the BIAs of interest by culturing the host cells under culture conditions that promote expression of enzymes encoded by the heterologous coding sequences of the host cells. Aspects of the invention further include compositions, e.g., host cells, starting compounds and kits, etc., that find use in methods of the invention.

  本发明的各个方面包括经改造可生产苄基异喹啉生物碱（BIAs）的宿主细胞。宿主细胞包括多种酶的异源编码序列，这些酶参与宿主细胞从起始化合物到 BIAs 的合成途径。本发明还提供了在促进宿主细胞异源编码序列所编码的酶的表达的培养条件下培养宿主细胞以生产所关注的 BIAs 的方法。本发明的各个方面还包括可用于本发明方法的组合物，如宿主细胞、起始化合物和试剂盒等。
• BENZYLISOQUINOLINE ALKALOIDS (BIA) PRODUCING MICROBES, AND METHODS OF MAKING AND USING THE SAME
  申请人：The Board of Trustees of the Leland Stanford Junior University

  公开号：EP3553177B1

  公开（公告）日：2020-12-09
• US20140273109A1
  申请人：——

  公开号：US20140273109A1

  公开（公告）日：2014-09-18
• METHOD OF MAKING A BENZYLISOQUINOLINE ALKALOID (BIA) METABOLITE, ENZYMES THEREFORE
  申请人：VALORBEC SOCIÉTÉ EN COMMANDITE

  公开号：US20160340704A1

  公开（公告）日：2016-11-24

  There is provided a method of preparing a benzylisoquinoline alkaloid (BIA) metabolite comprising: a. culturing a host cell under conditions suitable for protein production, including a pH of between about 7 and about 10 said host cell comprising: b. a first heterologous coding sequence encoding a first enzyme involved in a metabolite pathway that converts (R,S)-norlaudanosoline into the metabolite; c. a second heterologous coding sequence encoding a second enzyme involved in a metabolite pathway that converts (R,S)-norlaudanosoline into the metabolite; d. a third heterologous coding sequence encoding a second enzyme involved in a metabolite pathway that converts (R,S)-norlaudanosoline into the metabolite; (d) adding (R,S)-norlaudanosoline to the cell culture; and recovering the metabolite from the cell culture
• Improved Methods For Making and Using Polynucleotide Sequences in the Synthesis of Alkaloid Compounds
  申请人：EPIMERON INC.

  公开号：US20170058305A1

  公开（公告）日：2017-03-02

  Novel methods that may be used for the manufacture of plant alkaloid compounds and novel polynucleotide compounds are provided. The plant alkaloid compounds are useful as medicinal compounds.