| 1203607-43-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• CAS: 1203607-43-5
• 化学式: C₃₀H₄₆O₄
• 分子量: 470.693
• InChiKey: AZMFCSJGLKUUHF-PNZWEVGDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.65
• 重原子数：
  34.0
• 可旋转键数：
  1.0
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.93
• 拓扑面积：
  66.9
• 氢给体数：
  1.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  在 硫酸 作用下， 生成 3-oxo-olean-12α-hydroxy-28-oic acid γ-lactone
  参考文献：
  名称：

  Practical Application of Oxidation Using a Novel Na₂WO₄−H₂O₂ System under Neutral Conditions for Scale-Up Manufacturing of 12α-Hydroxy-3-oxooleanano-28,13-lactone: Key Intermediate of Endothelin A Receptor Antagonist S-0139

  摘要：

  Novel alcohol oxidation using a Na2WO4-H2O2 System was applied to manufacture 12 alpha-hydroxy-3-oxooleanano-28,13-lactone which is it key intermediate of S-0139. Oxidation of the hydroxyl group of oleanolic acid was optimized based oil the design of experiment (DoE) approach. Statistical analysis was used to maximize the yield of the corresponding ketone and minimize the generation of byproducts. The safety evaluation of this oxidation was also conducted in detail, and pilot manufacturing was achieved.

  DOI：

  10.1021/op900265h
• 作为产物：
  描述：

  3-氧代-12-烯-28-齐墩果酸 在 臭氧 作用下， 以 甲醇 、 N,N-二甲基乙酰胺 为溶剂， 生成
  参考文献：
  名称：

  Practical Application of Oxidation Using a Novel Na₂WO₄−H₂O₂ System under Neutral Conditions for Scale-Up Manufacturing of 12α-Hydroxy-3-oxooleanano-28,13-lactone: Key Intermediate of Endothelin A Receptor Antagonist S-0139

  摘要：

  Novel alcohol oxidation using a Na2WO4-H2O2 System was applied to manufacture 12 alpha-hydroxy-3-oxooleanano-28,13-lactone which is it key intermediate of S-0139. Oxidation of the hydroxyl group of oleanolic acid was optimized based oil the design of experiment (DoE) approach. Statistical analysis was used to maximize the yield of the corresponding ketone and minimize the generation of byproducts. The safety evaluation of this oxidation was also conducted in detail, and pilot manufacturing was achieved.

  DOI：

  10.1021/op900265h

文献信息

• Methods of making radiolabeled tracers and precursors thereof
  申请人：Casebier S. David

  公开号：US20070036716A1

  公开（公告）日：2007-02-15

  The present disclosure relates to a solid-phase process for the production of radiolabeled tracers, in particular for the production of 18 F-labeled compounds which may be used as Positron Emission Tomography (PET) radiolabeled tracers. The disclosure also relates to radiopharmaceutical kits comprising precursors to the radiolabeled tracers, which can be converted to the radiolabeled tracers using the processes described herein.

  本公开涉及一种固相过程，用于生产放射标记示踪剂，特别是用于生产可用作正电子发射断层扫描（PET）放射标记示踪剂的 18 F标记化合物。该公开还涉及包括放射标记示踪剂前体的放射性药剂套件，这些前体可以使用本文描述的过程转化为放射标记示踪剂。