3β-acetoxy-7,15-isopimaradiene-19-ol | 1188330-15-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 3β-acetoxy-7,15-isopimaradiene-19-ol
• 英文别名: 3β-acetoxy-7,15-isopimaradien-19-ol；[(1S,2S,4aR,4bS,7S,10aR)-7-ethenyl-1-(hydroxymethyl)-1,4a,7-trimethyl-3,4,4b,5,6,8,10,10a-octahydro-2H-phenanthren-2-yl] acetate
• CAS: 1188330-15-5
• 化学式: C₂₂H₃₄O₃
• 分子量: 346.51
• InChiKey: AUMHUSASFFPCHH-LUDAKILFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  25
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.77
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3β-acetoxy-7,15-isopimaradiene-19-ol 在 potassium hydroxide 作用下， 以 乙醇 为溶剂， 反应 36.0h， 以89.6%的产率得到Δ^7,8-virescenoside B aglycon
  参考文献：
  名称：

  Isopimarane diterpenoids from Aeollanthus rydingianus and their antimicrobial activity

  摘要：

  Four acyloxy-isopimarane derivatives along with two known isopimarane diterpenoids, the flavone cirsimaritin and the sterols P-sitosterol and stigmasterol were isolated from the aerial parts of Aeollanthus rydingianus. The structures of the compounds were established on the basis of spectroscopic analysis and chemical evidence. The isolated substances were screened for antimicrobial activity against Gram-positive and Gram-negative bacteria and a yeast strain. 19-Acetoxy-7,15-isopimaradien-3 beta-ol and 7,15-isopimaradien-19-ol showed minimum inhibitory concentration (MIC) values of 3.90-15.62 mu g/ml for Staphylococcus aureus and of 7.81 mu g/ml for Enterococcus hirae. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.phytochem.2009.06.008

文献信息

• Isopimarane diterpenoids from Aeollanthus rydingianus and their antimicrobial activity
  作者：Patricia Rijo、Maria Fátima Simões、Aida Duarte、Benjamín Rodríguez

  DOI：10.1016/j.phytochem.2009.06.008

  日期：2009.6

  Four acyloxy-isopimarane derivatives along with two known isopimarane diterpenoids, the flavone cirsimaritin and the sterols P-sitosterol and stigmasterol were isolated from the aerial parts of Aeollanthus rydingianus. The structures of the compounds were established on the basis of spectroscopic analysis and chemical evidence. The isolated substances were screened for antimicrobial activity against Gram-positive and Gram-negative bacteria and a yeast strain. 19-Acetoxy-7,15-isopimaradien-3 beta-ol and 7,15-isopimaradien-19-ol showed minimum inhibitory concentration (MIC) values of 3.90-15.62 mu g/ml for Staphylococcus aureus and of 7.81 mu g/ml for Enterococcus hirae. (C) 2009 Elsevier Ltd. All rights reserved.