(+)-17β-(N-phenylamino)-(5β)-10-azaestr-1-en-3-one | 477904-31-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: (+)-17β-(N-phenylamino)-(5β)-10-azaestr-1-en-3-one
• CAS: 477904-31-7
• 化学式: C₂₃H₃₀N₂O
• 分子量: 350.504
• InChiKey: QGPSHELRIFKJAW-SICDYIMMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.61
• 重原子数：
  26.0
• 可旋转键数：
  2.0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.61
• 拓扑面积：
  32.34
• 氢给体数：
  1.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  乙酸酐 、 (+)-17β-(N-phenylamino)-(5β)-10-azaestr-1-en-3-one 在 吡啶 作用下， 以100%的产率得到(+)-17β-[(N-phenyl)acetamido]-(5β)-10-azaestr-1-en-3-one
  参考文献：
  名称：

  Synthesis of 17β-N-Substituted 19-Nor-10-azasteroids as Inhibitors of Human 5α-Reductases I and II

  摘要：

  The synthesis of 17beta-[N-(phenyl)methyl/phenyl-amido] substituted 10-azasteroids has been accomplished by either the TiCl4- or TMSOTf-catalysed reaction of carbamates 11 and 12 with Danishefsky's diene. The reaction provided 5alpha-H isomers 3a-5a and 5beta-H isomers 3b-5b depending on the reaction conditions. Both epimers of each compound were tested against human 5alpha-reductase types I and II. Unexpectedly, 5beta-H compounds were found more active than their 5a-H counterparts, the best inhibitors being 3b (IC50=279 and 2000 nM toward isoenzyme I and II, respectively) and 5b (IC50=913 and 247 nM toward isoenzymes I and II, respectively). (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0968-0896(02)00254-7
• 作为产物：
  描述：

  (3aS,9aS,9bS)-3a-Methyl-3-[(E)-phenylimino]-1,2,3,3a,4,6,8,9,9a,9b-decahydro-6-aza-cyclopenta[a]naphthalen-7-one 在 盐酸 、 4-二甲氨基吡啶 、 三氟甲磺酸三甲基硅酯 、 三乙基硼氢化锂 、 sodium cyanoborohydride 、 三乙胺 作用下， 以 四氢呋喃 、 甲醇 、 二氯甲烷 为溶剂， 反应 60.75h， 生成 (+)-17β-(N-phenylamino)-(5β)-10-azaestr-1-en-3-one
  参考文献：
  名称：

  Synthesis of 17β-N-Substituted 19-Nor-10-azasteroids as Inhibitors of Human 5α-Reductases I and II

  摘要：

  The synthesis of 17beta-[N-(phenyl)methyl/phenyl-amido] substituted 10-azasteroids has been accomplished by either the TiCl4- or TMSOTf-catalysed reaction of carbamates 11 and 12 with Danishefsky's diene. The reaction provided 5alpha-H isomers 3a-5a and 5beta-H isomers 3b-5b depending on the reaction conditions. Both epimers of each compound were tested against human 5alpha-reductase types I and II. Unexpectedly, 5beta-H compounds were found more active than their 5a-H counterparts, the best inhibitors being 3b (IC50=279 and 2000 nM toward isoenzyme I and II, respectively) and 5b (IC50=913 and 247 nM toward isoenzymes I and II, respectively). (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0968-0896(02)00254-7