Toluene-4-sulfonic acid 7,8-dihydro-6H-5-oxa-1-aza-phenanthren-6-ylmethyl ester | 494194-23-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: Toluene-4-sulfonic acid 7,8-dihydro-6H-5-oxa-1-aza-phenanthren-6-ylmethyl ester
• 英文别名: 3,4-dihydro-2H-pyrano[2,3-f]quinolin-2-ylmethyl 4-methylbenzenesulfonate
• CAS: 494194-23-9
• 化学式: C₂₀H₁₉NO₄S
• 分子量: 369.441
• InChiKey: TYITZCJTHOJEGW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  26
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  73.9
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  Toluene-4-sulfonic acid 7,8-dihydro-6H-5-oxa-1-aza-phenanthren-6-ylmethyl ester 、 5-氟-3-(1,2,3,6-四氢吡啶-4-基)-1H-吲哚 在 氮 、 乙酸乙酯 、 碳酸氢钠 、 Brine 、 magnesium sulfate 、 silica gel 、 甲醇 、 二氯甲烷 、 yellow oil 、 异丙醇 、 草酸 作用下， 以 二甲基亚砜 为溶剂， 反应 13.0h， 以to give 0.043 g of the title compound as a yellow solid (m.p. 148° C.)的产率得到6-[4-(5-fluoro-1H-indol-3-yl)-3,6-dihydro-2H-pyridin-1-ylmethyl]-7,8-dihydro-6H-5-oxa-1aza-phenanthrene
  参考文献：
  名称：

  Antidepressant azahetorocyclylmethyl derivatives of 7,8-dihydro-6H-5-oxa-1-aza-phenanthrene

  摘要：

  该公式化合物可用于治疗抑郁症（包括但不限于重度抑郁障碍，儿童抑郁症和心境不稳定症），焦虑症，恐慌症，创伤后应激障碍，经前期不良情绪障碍（也称经前综合症），注意力缺陷障碍（伴有或不伴有多动症），强迫症（包括拔毛癖），社交焦虑障碍，广泛性焦虑障碍，肥胖症，饮食障碍（如厌食症，贪食症），潮红症，可卡因和酒精成瘾，性功能障碍（包括早泄）以及相关疾病。

  公开号：

  US20050228010A1
• 作为产物：
  描述：

  2H-pyrano[2,3-f]quinolin-2-yl-methyl 4-methylbenzene-sulfonate 在 钯 作用下， 以 乙醇 为溶剂， 以affords 3,4-dihydro-2H-pyrano[2,3-f]quinolin-2-ylmethyl 4-methylbenzenesulfonate的产率得到Toluene-4-sulfonic acid 7,8-dihydro-6H-5-oxa-1-aza-phenanthren-6-ylmethyl ester
  参考文献：
  名称：

  Process for synthesis of 2-yl chroman derivatives

  摘要：

  本发明提供了一种立体特异性制备式为1的2-基-色基和-色烯衍生物的过程： 这些化合物可用于制备光学活性的2-氨甲基-和2-氮杂杂环基甲基-色基。

  公开号：

  US20030100774A1

文献信息

• Antidepressant azaheterocyclylmethyl derivatives of 7,8-dihydro-6H-5-oxa-1-aza-phenanthrene
  申请人：Wyeth

  公开号：US20030078268A1

  公开（公告）日：2003-04-24

  Compounds of the formula 1 useful for the treatment of such as depression (including but not limited to major depressive disorder, childhood depression and dysthymia), anxiety, panic disorder, post-traumatic stress disorder, premenstrual dysphoric disorder (also known as pre-menstrual syndrome), attention deficit disorder (with and without hyperactivity), obsessive compulsive disorder (including trichotillomania), social anxiety disorder, generalized anxiety disorder, obesity, eating disorders such as anorexia nervosa, bulimia nervosa, vasomotor flushing, cocaine and alcohol addition, sexual dysfunction (including premature ejaculation), and related illnesses.

  该公式的化合物用于治疗抑郁症（包括但不限于重性抑郁障碍、儿童抑郁症和心境低落障碍）、焦虑、恐慌障碍、创伤后应激障碍、经前期失调性障碍（也称为经前综合征）、注意力缺陷障碍（伴有和不伴有多动症）、强迫症（包括拔毛症）、社交焦虑障碍、广泛性焦虑障碍、肥胖、饮食失调如厌食症、暴食症、血管运动性潮红、可卡因和酒精成瘾、性功能障碍（包括早泄）及相关疾病。
• Antidepressant azaheterocyclyl methyl derivatives of 7,8-dihydro-6H-5-oxa-1-aza-phenanthrene
  申请人：WYETH

  公开号：US20040235851A1

  公开（公告）日：2004-11-25

  Compounds of the formula 1 useful for the treatment of such as depression (including but not limited to major depressive disorder, childhood depression and dysthymia), anxiety, panic disorder, post-traumatic stress disorder, premenstrual dysphoric disorder (also known as pre-menstrual syndrome), attention deficit disorder (with and without hyperactivity), obsessive compulsive disorder (including trichotillomania), social anxiety disorder, generalized anxiety disorder, obesity, eating disorders such as anorexia nervosa, bulimia nervosa, vasomotor flushing, cocaine and alcohol addition, sexual dysfunction (including premature ejaculation), and related illnesses.

  公式为1的化合物，可用于治疗抑郁症（包括但不限于重度抑郁障碍、儿童抑郁症和慢性抑郁症）、焦虑症、惊恐障碍、创伤后应激障碍、经前期不良情绪障碍（也称为经前综合症）、注意力缺陷障碍（伴有或不伴有多动症）、强迫症（包括拔毛症）、社交焦虑障碍、广泛性焦虑障碍、肥胖症、饮食失调（如厌食症、贪食症）、潮红、可卡因和酒精成瘾、性功能障碍（包括早泄）及相关疾病的治疗。
• Process for stereoselective synthesis of 2-hydroxymethyl chromans
  申请人：Wyeth

  公开号：US20030105342A1

  公开（公告）日：2003-06-05

  A process for the stereoselective synthesis of 2-hydroxymethyl-chromans of formula (II) is provided 1 where R, R 1 , R 2 and R 3 are as defined herein. The compound of formula (II) is prepared using an optically active benzene compound of formula (I) 2 where R 0 is as defined herein. The 2-hydroxymethyl-chroman compounds of formula (II) are useful as intermediates for preparing a variety of medicinal agents.

  提供了一种对式选择性合成公式（II）的2-羟甲基-色基的过程，其中R、R1、R2和R3如此处所定义。使用公式（I）的光学活性苯化合物（其中R0如此处所定义）制备公式（II）的化合物。公式（II）的2-羟甲基-色基化合物可用作制备各种药物的中间体。
• Antidepressant azahetorocyclylmethyl derivatives of 7,8-dihydro-6H-5-oxa-1-aza-phenathrene
  申请人：Wyeth

  公开号：US07030245B2

  公开（公告）日：2006-04-18

  Compounds of the formula useful for the treatment of such as depression (including but not limited to major depressive disorder, childhood depression and dysthymia), anxiety, panic disorder, post-traumatic stress disorder, premenstrual dysphoric disorder (also known as pre-menstrual syndrome), attention deficit disorder (with and without hyperactivity), obsessive compulsive disorder (including trichotillomania), social anxiety disorder, generalized anxiety disorder, obesity, eating disorders such as anorexia nervosa, bulimia nervosa, vasomotor flushing, cocaine and alcohol addition, sexual dysfunction (including premature ejaculation), and related illnesses.

  以下化合物的配方对于治疗抑郁症（包括但不限于重度抑郁障碍、儿童抑郁症和慢性心境低落）、焦虑症、惊恐障碍、创伤后应激障碍、月经前期失调症（也称为经前综合症）、注意力缺陷障碍（伴有或不伴有多动症）、强迫症（包括拔毛癖）、社交焦虑障碍、广泛性焦虑障碍、肥胖症、饮食障碍（如厌食症、贪食症）、潮红、可卡因和酒精成瘾、性功能障碍（包括早泄）以及相关疾病有用：
• A PROCESS FOR THE STEREOSELECTIVE SYNTHESIS OF 2-HYDROXYMETHYL-CHROMANS
  申请人：Wyeth

  公开号：EP1432695A1

  公开（公告）日：2004-06-30