12-chloro-dodecanal | 100246-64-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 12-chloro-dodecanal
• 英文别名: 12-Chlorododecanal
• CAS: 100246-64-8
• 化学式: C₁₂H₂₃ClO
• 分子量: 218.767
• InChiKey: GUGVYHHCAOZNLK-UHFFFAOYSA-N

物化性质

• 沸点：
  103-105 °C(Press: 20 Torr)
• 密度：
  0.929±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  14
• 可旋转键数：
  11
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  12-chloro-dodecanal 在 silica gel 、 对甲苯磺酸 作用下， 以 环丁砜 、 水 为溶剂， 生成 cis-24-bromotetracos-12-enal
  参考文献：
  名称：

  Bidd, Ilesh; Holdup, David W.; Whiting, Mark C., Journal of the Chemical Society. Perkin transactions I, 1987, p. 2455 - 2464

  摘要：

  DOI：
• 作为产物：
  描述：

  11-氯-1-十一碳炔 在 锌 、 镍 氢气 、 草酸 作用下， 生成 12-chloro-dodecanal
  参考文献：
  名称：

  Epsztein,R. et al., Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1961, vol. 252, p. 1803 - 1805

  摘要：

  DOI：

文献信息

• A versatile process for the syntheses of very long chain alkanes, functionalised derivatives and some branched chain hydrocarbons
  作者：Gerald M. Brooke、Simon Burnett、Shahid Mohammed、David Proctor、Mark C. Whiting

  DOI：10.1039/p19960001635

  日期：——

  An earlier method for synthesising very long straight-chain alkanes of very specific lengths has been improved to give, in some cases, gram amounts of materials. Eleven compounds have been made: C98H198, C122H246, C162H326, C194H390, C198H398, C210H422, C242H486, C246H494, C258H518, C294H590 and C390H782. The self-condensation reaction of one of the intermediate aldehydes enabled two chain-branched hydrocarbons to be obtained: C96H193CHRC94H189 where R = CH3 and CH3(CH2)3. Three long-chain compounds containing carboxylic acid groups have been prepared: CH3(CH2)190CO2H,HO2C(CH2)48CO2H and HO2C(CH2)192CO2H.

  一种早期合成特定长度的长直链烷烃的方法已得到改进，在某些情况下可以得到克量的材料。已制备十一种化合物：C98H198、C122H246、C162H326、C194H390、C198H398、C210H422、C242H486、C246H494、C258H518、C294H590和C390H782。其中一种中间体醛的自缩合反应能够得到两种链支化烃：C96H193CHRC94H189，其中R = CH3和CH3(CH2)3。制备了三种含羧酸基团的长链化合物：CH3(CH2)190CO2H、HO2C(CH2)48CO2H和HO2C(CH2)192CO2H。
• Pyrimidine nucleoside derivatives having anti-tumor activity, their preparation and use
  申请人：Sankyo Company Limited

  公开号：EP0536936A1

  公开（公告）日：1993-04-14

  Compounds of formula (I): [in which: R¹, R² and R³ are the same or different and each represents a hydrogen atom, an optionally substituted alkanoyl group or an alkenylcarbonyl group, provided that at least one of R¹, R² and R³ represents an unsubstituted alkanoyl group having from 5 to 24 carbon atoms, said substituted alkanoyl group or said alkenylcarbonyl group; and one of R⁴ and R⁵ represents a hydrogen atom and the other represents a cyano group]; have valuable anti-tumour activity.

  式子（I）的化合物：[其中：R¹、R²和R³相同或不同，每个代表氢原子、可选取代的脂肪酰基团或烯基羰基团，前提是至少有一个R¹、R²和R³代表有5到24个碳原子的未取代脂肪酰基团，或者是所述取代的脂肪酰基团或所述烯基羰基团；R⁴和R⁵中的一个代表氢原子，另一个代表氰基]，具有有价值的抗肿瘤活性。
• BIPOLAR LIPIDS AND THEIR USE FOR THE DELIVERY OF BIOACTIVE SUBSTANCES
  申请人：Celltech R&D Limited

  公开号：EP1187807B1

  公开（公告）日：2007-07-25
• US5691319A
  申请人：——

  公开号：US5691319A

  公开（公告）日：1997-11-25
• [EN] BIPOLAR LIPIDS AND THEIR USE FOR THE DELIVERY OF BIOACTIVE SUBSTANCES<br/>[FR] LIPIDES BIPOLAIRES ET UTILISATION DE CES DERNIERS POUR LA LIBERATION DE SUBSTANCES BIOACTIVES
  申请人：CELLTECH THERAPEUTICS LTD

  公开号：WO2000064858A1

  公开（公告）日：2000-11-02

  Bipolar lipids are described which are able to form complexes with polyanions. The lipids comprise a cationic head linked to a hydrophobic backbone and a hydrophilic tail and are capable of self assembly to form stable complexes in aqueous solutions. The lipids are of particular use for the delivery of bioactive substances such as nucleic acids to cells in vitro and especially in vivo.