(E)-7-methyl-2-octenoic acid | 1258519-35-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (E)-7-methyl-2-octenoic acid
• 英文别名: (E)-7-methyloct-2-enoic acid
• CAS: 1258519-35-5
• 化学式: C₉H₁₆O₂
• 分子量: 156.225
• InChiKey: QEIAQASOSOCTKP-FNORWQNLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  11
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (E)-7-methyl-2-octenoic acid 在 草酰氯 、 N,N-二甲基甲酰胺 作用下， 以 苯 为溶剂， 反应 0.5h， 生成 7-methyl-2-octenoyl chloride
  参考文献：
  名称：

  Synthesis and biological activities of flavolipids

  摘要：

  Syntheses of the bacterial surfactants 6S 6S- 9S 9S- and 9U 9U-flavolipids confirmed the structures proposed for them from spectroscopic analysis of a flavolipid mixture and made pure flavolipids available for the first time All three synthetic flavolipids and a straight chain analogue were found to be weakly cytotoxic and to inhibit metastatic cancer cell migration with 9U 9U-fiavolipid (the most abundant natural flavolipid) having the most activity Biosynthetic routes to the branched side-chains of the flavolipids are suggested and it is proposed that branched chains are employed to hinder biodegradation (C) 2010 Elsevier Ltd All rights reserved

  DOI：

  10.1016/j.tet.2010.09.088
• 作为产物：
  描述：

  5-甲基-1-己醇 在 草酰氯 、 sodium hydride 、 二甲基亚砜 、 lithium hydroxide 作用下， 以 四氢呋喃 、 乙二醇二甲醚 、 二氯甲烷 、 水 为溶剂， 反应 7.5h， 生成 (E)-7-methyl-2-octenoic acid
  参考文献：
  名称：

  链霉菌天蓝色解离的脂肪酸合酶的FabG和FabI的表征。

  摘要：

  功能性串扰：鉴定并鉴定了来自天蓝色链霉菌的β-酮酰基-酰基载体蛋白（ACP; FabG）和烯酰-ACP还原酶（FabI）。动力学分析表明，这些酶可处理直链和支链底物，以及来自脂肪酸和十一烷基脯氨酸的生物合成途径中的ACP。这种松弛的底物特异性使这些酶参与了两个过程。

  DOI：

  10.1002/cbic.201402670

文献信息

• US6020371A
  申请人：——

  公开号：US6020371A

  公开（公告）日：2000-02-01
• [EN] HYDROCAPSULES AND METHOD OF PREPARATION<br/>[FR] HYDROCAPSULES ET LEUR PROCEDE DE PREPARATION
  申请人：ANALYTICAL RES SYSTEMS

  公开号：WO2003059503A1

  公开（公告）日：2003-07-24

  A method is described for the formation of microcapsules which contain a liquid composition in the core, which is surrounded by a polymeric shell, membrane, or coating. The microcapsules are produced by simultaneously extruding the liquid core material along with a polymerizable liquid through concentrically-aligned nozzles to form spherically-layered biliqued droplets, followed by energy input in the form of heat or light which causes polymerization of the outer layer. The capsules formed by this method are capable of containing a variety of liquid materials having a composit ion ranging from completely aqueous to completely non-aqueous.
• Characterization of FabG and FabI of the<i>Streptomyces coelicolor</i>Dissociated Fatty Acid Synthase
  作者：Renu Singh、Kevin A. Reynolds

  DOI：10.1002/cbic.201402670

  日期：2015.3.2

  Functional crosstalk: β‐Ketoacyl‐acyl carrier protein (ACP; FabG) and enoyl‐ACP reductase (FabI) from Streptomyces coelicolor were identified and characterized. Kinetic analysis demonstrated that these enzymes process straight and branched‐chain substrates along with the ACPs from both fatty acid and undecylprodiginine biosynthetic pathways. This relaxed substrate specificity allow these enzymes to

  功能性串扰：鉴定并鉴定了来自天蓝色链霉菌的β-酮酰基-酰基载体蛋白（ACP; FabG）和烯酰-ACP还原酶（FabI）。动力学分析表明，这些酶可处理直链和支链底物，以及来自脂肪酸和十一烷基脯氨酸的生物合成途径中的ACP。这种松弛的底物特异性使这些酶参与了两个过程。
• Synthesis and biological activities of flavolipids
  作者：Samiul M. Ahad、Alison L. Ange、Robert B. Bates、Bonnie L. Bell、Adria A. Bodour、Bryan R. Bourne、Cristina G. Contreras、Emily L. Goldberg、A.A. Leslie Gunatilaka、Sheryl King、Albert K. Lee、Rebecca L. Low、Raina M. Maier、Kathryn M. Marlor、Marilyn T. Marron、Ryan C. Scolnik、Matthew J. Streeter、Malgorzata Strelczuk、Long N. Trinh、Vu K. Truong、Sage P. Vissering、Megan C. Weick、Maria T. Williams

  DOI：10.1016/j.tet.2010.09.088

  日期：2010.11

  Syntheses of the bacterial surfactants 6S 6S- 9S 9S- and 9U 9U-flavolipids confirmed the structures proposed for them from spectroscopic analysis of a flavolipid mixture and made pure flavolipids available for the first time All three synthetic flavolipids and a straight chain analogue were found to be weakly cytotoxic and to inhibit metastatic cancer cell migration with 9U 9U-fiavolipid (the most abundant natural flavolipid) having the most activity Biosynthetic routes to the branched side-chains of the flavolipids are suggested and it is proposed that branched chains are employed to hinder biodegradation (C) 2010 Elsevier Ltd All rights reserved