{1,1,1-trifluoro-2-[4-(1-methylethyl)phenyl]pent-4-ene-2-ylsulfonyl}benzene | 1402748-72-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: {1,1,1-trifluoro-2-[4-(1-methylethyl)phenyl]pent-4-ene-2-ylsulfonyl}benzene
• CAS: 1402748-72-4
• 化学式: C₂₀H₂₁F₃O₂S
• 分子量: 382.447
• InChiKey: GEZJWVIAJQEVQV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
  None
• 氢给体数：
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• 氢受体数：
  None

反应信息

• 作为产物：
  描述：

  在 tris-(dibenzylideneacetone)dipalladium(0) 、 间氯过氧苯甲酸 、 1,2-双(二苯基膦)乙烷 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 1.0h， 生成 {1,1,1-trifluoro-2-[4-(1-methylethyl)phenyl]pent-4-ene-2-ylsulfonyl}benzene
  参考文献：
  名称：

  Decarboxylative Allylation of Trifluoroethyl Sulfones and Approach to Difluoromethyl Compounds

  摘要：

  Ally, carbonates undergo palladium-catalyzed decarboxylative allylation of trifluoroethyl phenyl sulfones. The success of the allylation, which is not efficient under typical strong base-mediated conditions, is the result of mild conditions thanks to a progressive delivery of ethoxide. Indeed, ethyl allyl carbonates act as a latent source of ethoxide for generation of the trifluoroethyl carbanion that reacts with the pi-allylpalladium complex. The utility of the method is illustrated in a new approach to difluoromethyl compounds.

  DOI：

  10.1021/ol302589w

文献信息

• Trimethoxyphenylthio as a Highly Labile Replacement for <i>tert</i>-Butylthio Cysteine Protection in Fmoc Solid Phase Synthesis
  作者：Tobias M. Postma、Matthieu Giraud、Fernando Albericio

  DOI：10.1021/ol3025499

  日期：2012.11.2

  Trimethoxyphenylthio (S-Tmp) is described as a novel cysteine protecting group in Fmoc solid phase peptide synthesis replacing the difficult to remove tert-butylthio. S-Tmp and dimethoxyphenylthio (S-Dmp) were successfully used for cysteine protection in a variety of peptides. Moreover, both groups can be removed in 5 min with mild reducing agents. S-Tmp is recommended for cysteine protection, as it yields crude peptides of high purity.