Ethyl 5-(4-isopropylphenyl)-2-methylthiazole-4-carboxylate | 1092504-56-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: Ethyl 5-(4-isopropylphenyl)-2-methylthiazole-4-carboxylate
• 英文别名: ethyl 2-methyl-5-(4-propan-2-ylphenyl)-1,3-thiazole-4-carboxylate
• CAS: 1092504-56-7
• 化学式: C₁₆H₁₉NO₂S
• 分子量: 289.398
• InChiKey: CVNYCZSSHNFXIO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  20
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  67.4
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  Ethyl 5-(4-isopropylphenyl)-2-methylthiazole-4-carboxylate 在 氢氧化钾 、 polystyrene resin-bound N-cyclohexylcarbodiimide 、 水 、 1-羟基苯并三唑 作用下， 以 甲醇 、 N,N-二甲基甲酰胺 为溶剂， 反应 0.5h， 生成 N-[4-[4-[(2,6-dichlorophenyl)carbamoyl]piperazin-1-yl]phenyl]-2-methyl-5-(4-propan-2-ylphenyl)-1,3-thiazole-4-carboxamide
  参考文献：
  名称：

  [EN] PIPERIDINE/PIPERAZINE DERIVATIVES
  [FR] DÉRIVÉS DE PIPERIDINE/PIPERAZINE

  摘要：

  公开号：

  WO2008148849A8
• 作为产物：
  描述：

  2-甲基噻唑-4-甲酸乙酯 、 1-碘-4-异丙苯 在 palladium diacetate 、 1,5-双(二苯基膦)戊烷 potassium acetate 作用下， 以 N-甲基吡咯烷酮 为溶剂， 反应 24.0h， 生成 Ethyl 5-(4-isopropylphenyl)-2-methylthiazole-4-carboxylate
  参考文献：
  名称：

  [EN] PIPERIDINE/PIPERAZINE DERIVATIVES
  [FR] DÉRIVÉS DE PIPERIDINE/PIPERAZINE

  摘要：

  公开号：

  WO2008148849A8

文献信息

• Piperidine/piperazine derivatives
  申请人：Janssen Pharmaceutica, N.V.

  公开号：EP2155198B1

  公开（公告）日：2014-08-13
• PIPERIDINE/PIPERAZINE DERIVATIVES
  申请人：Bongartz Jean-Pierre Andre Marc

  公开号：US20100210618A1

  公开（公告）日：2010-08-19

  The invention relates to a DGAT inhibitor of formula (I), including any stereochemically isomeric form thereof, wherein A represents CH or N; the dotted line represents an optional bond in case A represents a carbon atom; X represents —O—C(═O)—; —C(═O)—C(═O)—; —NR X —C(═O)—; —Z—C(═O)—; —Z—NR X —C(═O)—; —C(═O)—Z—; —NR X —C(═O)—Z—; —C(═S)—; —NR X —C(═S)—; —Z—C(═S)—; —Z—NR X —C(═S)—; —C(═S)—Z—; —NR X —C(═S)—Z—; Z represents a bivalent radical selected from C 1-6 alkanediyl, C 2-6 alkenediyl or C 2-6 alkynediyl; wherein each of said C 1-6 alkanediyl, C 2-6 alkenediyl or C 2-6 alkynediyl may optionally be substituted; and wherein two hydrogen atoms attached to the same carbon atom in C 1-6 alkanediyl may optionally be replaced by C 1-6 alkanediyl; Y represents —C(═O)—NR X — or —NR X —C(═O)—; R 1 represents adamantanyl, C 3-6 cycloalkyl; aryl 1 or Het 1 ; R 2 represents C 3-6 cycloalkyl, phenyl, naphtalenyl, 2,3-dihydro-1,4-benzodioxinyl, 1,3-benzodioxolyl, 2,3-dihydrobenzofuranyl or a 6-membered aromatic heterocycle containing 1 or 2 N atoms, wherein said C 3-6 Cycloalkyl, phenyl, naphtalenyl, 2,3-dihydro-1,4-benzodioxinyl, 1,3-benzodioxolyl or heterocycle may optionally be substituted; R 7 represents hydrogen, halo, C 1-4 alkyl, C 1-4 alkyl substituted with hydroxyl; provided that the following compounds (II), (III) are excluded; a N-oxide thereof, a pharmaceutically acceptable salt thereof or a solvate thereof. The invention further relates to methods for preparing such compounds, pharmaceutical compositions comprising said compounds as well as the use as a medicine, as a DGAT inhibitor, of said compounds.
• US8946228B2
  申请人：——

  公开号：US8946228B2

  公开（公告）日：2015-02-03
• US9227935B2
  申请人：——

  公开号：US9227935B2

  公开（公告）日：2016-01-05
• [EN] PIPERIDINE/PIPERAZINE DERIVATIVES<br/>[FR] DÉRIVÉS DE PIPERIDINE/PIPERAZINE
  申请人：JANSSEN PHARMACEUTICA NV

  公开号：WO2008148849A8

  公开（公告）日：2009-07-09