5-Methyl-2-phenyl-4-imidazolecarboxaldehyde | 68282-50-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 5-Methyl-2-phenyl-4-imidazolecarboxaldehyde
• 英文别名: 5(4)-methyl-2-phenyl-1H-imidazole-4(5)-carboxaldehyde；2-phenyl-4-formyl-5-methyl-1H-imidazole；5-methyl-2-phenyl-1(3)H-imidazole-4-carbaldehyde；5-Methyl-2-phenyl-1(3)H-imidazol-4-carbaldehyd；5-Methyl-2-phenyl-1h-imidazole-4-carbaldehyde
• CAS: 68282-50-8
• 化学式: C₁₁H₁₀N₂O
• 分子量: 186.213
• InChiKey: KFVGBCOFGJKBPM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  45.8
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  5-Methyl-2-phenyl-4-imidazolecarboxaldehyde 在 盐酸 、 amalgamated zinc 作用下， 生成 1H-咪唑,4,5-二甲基-2-苯基-
  参考文献：
  名称：

  144.苯甲idine与α-二酮的缩合

  摘要：

  DOI：

  10.1039/jr9480000731
• 作为产物：
  描述：

  4-甲基-2-苯基-5-羟甲基-1H-咪唑 以 乙醇 、 水 、 硝酸 为溶剂， 生成 5-Methyl-2-phenyl-4-imidazolecarboxaldehyde
  参考文献：
  名称：

  Substituted imidazo (1,5-D)-as-triazin-4-ols, and herbicidal use thereof

  摘要：

  提供了替代咪唑[1,5-d]-三嗪-4-醇，可用作除草剂，用于预防和控制不需要的单子叶和双子叶植物的出苗前和出苗后。

  公开号：

  US04126444A1
• 作为试剂：
  描述：

  Benzooxazol-2-yl-piperidin-4-yl-amine dihydrobromide 、 5-Methyl-2-phenyl-4-imidazolecarboxaldehyde 、 溶剂黄146 、 氰基硼氢化钠 在 5-Methyl-2-phenyl-4-imidazolecarboxaldehyde 、 acetonitrile-water 作用下， 以 乙醇 为溶剂， 反应 0.5h， 以provided 17.0 mg (15%) of the title compound的产率得到benzooxazol-2-yl-[1-(5-methyl-2-phenyl-1H-imidazol-4-ylmethyl)-piperidin-4-yl]-amine
  参考文献：
  名称：

  Benzothiazole, thiazolopyridine, benzooxazole and oxazolopyridine derivatives

  摘要：

  本发明涉及式中A、B1、B2、R1、R2和G所定义的化合物及其药学上可接受的盐。本发明还涉及含有这种化合物的制药组合物，以及制备这种化合物的过程和它们用于治疗和/或预防与SST受体亚型5调节相关的疾病的用途。

  公开号：

  US20060205718A1

文献信息

• Substituted imidazolyl-alkyl-piperazine and -diazepine derivatives
  申请人：Syntex Pharmaceuticals, Ltd.

  公开号：US05043447A1

  公开（公告）日：1991-08-27

  Substituted imidazolyl-alkyl-piperazine and diazepine derivatives of Formula A: ##STR1## wherein: R.sup.1 is aryl, lower alkyl, cycloalkyl or hydrogen; R.sup.2 is aryl, lower alkyl or hydrogen; R.sup.3 is lower alkyl, hydroxy, or hydrogen; R.sup.4 is aryl or hydrogen; R.sup.5 is aryl or hydrogen; m is two or three; n is zero, one or two, provided that when R.sup.3 is hydroxy, n is one or two; and q is zero, one, two, or three; and the pharmaceutically acceptable salts thereof, are useful for treating mammals having any of a variety of disease states including: diseases treated by direct neuronal protection, such as ischemia including focal and global ischemia, spinal injuries, head trauma, and neurological diseases such as Alzheimer's and Huntington's chorea; diseases treated by inhibition of sodium ion, such as uremic and hyponatremic encephalopathy; and diseases treated with calcium channel antagonists, including: diseases treated by inhibiting cerebrovascular vasospasm and by cerebrovascular vasodilation, such as migraine, stroke, vasospasm due to subarachnoid hemorrhage, epilepsy or epileptic psychotic symptoms, and cerebrovascular ischemia induced by cocaine abuse; and cardiovascular diseases, such as hypertension, angina, stable and unstable angina, Prinzmetal angina, arrhythmia, thrombosis, embolism, and congestive heart failure such as chronic or acute cardiac failure; and ischemia of lower legs due to peripheral vascular disease, e.g., intermittent claudication; spasms of smooth muscle: such as the ureter, the bladder, uterine cramps, diuresis, and irritable bowel syndrome; and uses during surgery: such as bypass grafts, angiography, angioplasty, organ preservation during transplant, hypertensive crisis, or post operative hypertension.

  Formula A的咪唑基-烷基-哌嗪和二氮杂环衍生物：##STR1##其中：R.sup.1为芳基，较低烷基，环烷基或氢；R.sup.2为芳基，较低烷基或氢；R.sup.3为较低烷基，羟基或氢；R.sup.4为芳基或氢；R.sup.5为芳基或氢；m为二或三；n为零，一或二，但当R.sup.3为羟基时，n为一或二；q为零，一，二或三；及其药学上可接受的盐，用于治疗患有各种疾病状态的哺乳动物，包括：通过直接神经保护治疗的疾病，如缺血，包括局部和全局缺血，脊髓损伤，头部创伤以及阿尔茨海默病和亨廷顿舞蹈症等神经系统疾病；通过抑制钠离子治疗的疾病，如尿毒症和低钠性脑病；以及通过钙通道拮抗剂治疗的疾病，包括：通过抑制脑血管痉挛和脑血管扩张治疗的疾病，如偏头痛，中风，由蛛网膜下腔出血引起的血管痉挛，癫痫或癫痫性精神症状，以及可卡因滥用引起的脑血管缺血；以及心血管疾病，如高血压，心绞痛，稳定和不稳定性心绞痛，普林兹梅塔心绞痛，心律失常，血栓形成，栓塞，以及慢性或急性心力衰竭，以及由于外周血管疾病引起的下肢缺血，例如间歇性跛行；平滑肌痉挛：如输尿管，膀胱，子宫痉挛，利尿和肠易激综合征；以及手术期间的用途：如旁路移植，血管造影，血管成形术，器官移植期间的器官保护，高血压危机或术后高血压。
• Method for the control of undesired plant species using
  申请人：American Cyanamid Company

  公开号：US04168964A1

  公开（公告）日：1979-09-25

  This disclosure describes herbicidal methods for the pre- and postemergence control of undesired mono- and dicotyledonous plants using substituted imidazo[1,5-d]-as-triazin-4(3H)-ones and substituted imidazo[1,5-d]-as-triazine-4(3H)-thiones.

  本公开描述了使用取代的咪唑[1,5-d]-嘧啶-4(3H)-酮和取代的咪唑[1,5-d]-嘧啶-4(3H)-硫醚来进行对不受欢迎的单子叶和双子叶植物的前期和后期除草的除草方法。
• Imidazo[1,5-d]-as-triazines
  申请人：American Cyanamid Company

  公开号：US04107308A1

  公开（公告）日：1978-08-15

  There are provided novel substituted imidazo-[1,5-d]-as-triazines useful as hypotensive agents as well as exhibiting herbicidal activity.

  提供了一种新型的取代咪唑-[1,5-d]-三嗪类化合物，可用作降压药物，同时具有除草活性。
• Imidazo [1,5-d]-as-triazine-4(3H)-ones and thiones
  申请人：American Cyanamid Company

  公开号：US04107307A1

  公开（公告）日：1978-08-15

  There is provided substituted imidazo[1,5-d]-as-triazine-4(3H)-ones and substituted imidazo[1,5-d]-as-triazin-4(3H)-thiones useful as inhibitors of the enzyme cyclic-AMP phosphodiesterase and as broad spectrum herbicides.

  提供了替代的咪唑[1,5-d]-嘧啶-4(3H)-酮和替代的咪唑[1,5-d]-嘧啶-4(3H)-硫酮，可用作环磷酸腺苷磷酸二酯酶的抑制剂和广谱除草剂。
• Substituted 3-(4-imidazolylmethylene)carbazic and thiocarbazic acid
  申请人：American Cyanamid Company

  公开号：US04124766A1

  公开（公告）日：1978-11-07

  There are provided substituted 3-(4-imidazolyl-methylene)carbazic acid esters and 3-(4-imidazolylmethylene)dithiocarbazic acid esters useful as intermediates for the preparation of compounds which inhibit the enzyme cyclic-AMP phosphodiesterase.

  提供了3-(4-咪唑基亚甲基)咔巴酸酯和3-(4-咪唑基亚甲基)二硫咔巴酸酯，用作制备抑制酶环磷酸腺苷磷酸二酯酶的化合物的中间体。