4-甲基-2-苯基-5-羟甲基-1H-咪唑 | 13682-32-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 中文名称: 4-甲基-2-苯基-5-羟甲基-1H-咪唑
• 中文别名: 5-甲基-2-苯基-1H-咪唑-4-甲醇；4-羟甲基-5-甲基-2-苯基咪唑
• 英文名称: Phenyl-2-methyl-5-hydroxymethyl-4-imidazol
• 英文别名: 4-Hydroxymethyl-5-methyl-2-phenylimidazol；5-Methyl-2-phenyl-4-imidazolemethanol；(5-methyl-2-phenyl-1(3)H-imidazol-4-yl)-methanol；5-methyl-2-phenyl-1H-imidazole-4-methanol；1H-Imidazole-4-methanol, 5-methyl-2-phenyl-；(5-methyl-2-phenyl-1H-imidazol-4-yl)methanol
• CAS: 13682-32-1
• 化学式: C₁₁H₁₂N₂O
• mdl: MFCD00047016
• 分子量: 188.229
• InChiKey: RUEBPOOTFCZRBC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.181
• 拓扑面积：
  48.9
• 氢给体数：
  2
• 氢受体数：
  2

安全信息

• 海关编码：
  2933290090
• 危险性防范说明：
  P261,P305+P351+P338
• 危险性描述：
  H302,H315,H319,H335

反应信息

• 作为反应物：
  描述：

  4-甲基-2-苯基-5-羟甲基-1H-咪唑 以 乙醇 、 水 、 硝酸 为溶剂， 生成 5-Methyl-2-phenyl-4-imidazolecarboxaldehyde
  参考文献：
  名称：

  Substituted imidazo (1,5-D)-as-triazin-4-ols, and herbicidal use thereof

  摘要：

  提供了替代咪唑[1,5-d]-三嗪-4-醇，可用作除草剂，用于预防和控制不需要的单子叶和双子叶植物的出苗前和出苗后。

  公开号：

  US04126444A1
• 作为产物：
  描述：

  5-甲基-2-苯基-3H-咪唑-4-羧酸乙酯 在 lithium aluminium tetrahydride 作用下， 以 乙醚 为溶剂， 反应 3.0h， 生成 4-甲基-2-苯基-5-羟甲基-1H-咪唑
  参考文献：
  名称：

  Synthesis and pharmacological evaluation of a novel series of 3-aryl-2-(2-substituted-4-methylthiazole-5-yl)thiazolidin-4-one as possible anti-inflammatory and antimicrobial agents

  摘要：

  A new series of 3-aryl-2-(2-aryl/benzyl-4-methylthiazole-5-yl)thiazolidin-4-one was synthesized by condensation of 2-aryl/benzyl-4-methylthiazole-5-carbaldehyde, aromatic amines and thioglycolic acid in toluene. All the synthesized compounds are characterized by IR, NMR and elemental or mass analysis. Sixteen out of the newly synthesized compounds were screened for in vivo anti-inflammatory activity using carrageenan-induced rat paw edema method. Some of the synthesized compounds exhibited good anti-inflammatory activity compared with indomethacin. The synthesized compounds were also evaluated for their in vitro antimicrobial activity. Some of the compounds showed mild antibacterial activity while most of the compounds showed good antifungal activity. (c) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2012.08.073

文献信息

• [EN] PROCESS FOR PREPARATION OF ALUMINUM SALT OF PHOSPHONIC ACID ESTER<br/>[FR] PROCÉDÉ DE PRÉPARATION D'UN SEL D'ALUMINIUM D'UN ESTER D'ACIDE PHOSPHONIQUE
  申请人：ICL IP AMERICA INC

  公开号：WO2013077989A1

  公开（公告）日：2013-05-30

  There is provided herein a process for the preparation of aluminum salts of phosphonic acid esters by reacting phosphonic acid diesters with aluminum hydroxide in the presence of a catalyst. The catalyst is selected from the group consisting of a phase transfer catalyst, a thermally stable tertiary amine having a boiling point higher than about 140°C, a thermally stable tertiary phosphine having a boiling point higher than 140°C and combinations thereof. The aluminum phosphonates prepared can be used for making flame retarded thermoplastic polymers.

  本文提供了一种制备磷酸酯铝盐的方法，通过在催化剂存在下将磷酸二酯与氢氧化铝反应。催化剂选自相转移催化剂、热稳定的沸点高于约140°C的三级胺、热稳定的沸点高于140°C的三级膦和它们的组合。制备的铝磷酸盐可用于制备阻燃热塑性聚合物。
• [EN] BUTADIEN2,3-DIYL LINKED DI-DOPO DERIVATIVES AS FLAME RETARDANTS<br/>[FR] DÉRIVÉS DE DI-DOPO LIÉS OAR BUTADIÈN-2,3-DIYLE EN TANT QUE RETARDATEURS DE FLAMME
  申请人：ALBEMARLE CORP

  公开号：WO2014179688A1

  公开（公告）日：2014-11-06

  Disclosed are novel, halogen-free flame-retardants derived from 9,10-Dihydro-9-Oxa-10-Phosphaphenantrene-10-oxide (DOPO) of the structure below: This invention also relates to the use of the halogen free DOPO derived compositions as flame-retardants in polymers, and a process of preparing the above compounds by reacting a formula A compound with a formula B compound:

  本发明涉及从下面结构的9,10-二氢-9-氧-10-磷杂菲-10-氧化物（DOPO）衍生的新型无卤素阻燃剂：该发明还涉及将无卤素DOPO衍生组合物用作聚合物中的阻燃剂，并通过将式A化合物与式B化合物反应制备上述化合物的方法。
• [EN] IMPROVEMENTS IN OR RELATING TO CURATIVES<br/>[FR] AMÉLIORATIONS APPORTÉES OU SE RAPPORTANT À DES AGENTS DE DURCISSEMENT
  申请人：HEXCEL COMPOSITES LTD

  公开号：WO2020216688A1

  公开（公告）日：2020-10-29

  The host compound in a clathrate is an amino or hydroxyl containing aromatic phosphorous compound, clathrates containing a resin curative and their use in curable resin compositions to produce moulded articles particularly fibre reinforced articles.

  在蛛网状化合物中的宿主化合物是一种含氨基或羟基的芳香磷化合物，这些蛛网状化合物含有树脂固化剂，可用于可固化树脂组合物中，以生产模塑制品，特别是纤维增强制品。
• CURING AGENTS FOR EPOXY RESINS
  申请人：Dershem Stephen M

  公开号：US20130012620A1

  公开（公告）日：2013-01-10

  The present invention relates to curatives for epoxy resins, and compositions (e.g. adhesives) containing such resins cured using the same methods of preparation and uses therefor. More specifically, the present invention relates to hybrid curatives for epoxy resins comprising both aromatic amine, phenol and/or phenyl ester moieties. A further aspect of the current invention relates to new imidazole catalysts that possess a combination of excellent cure latency as well as low cure temperature onset.

  本发明涉及环氧树脂的硬化剂，以及含有经相同制备方法固化的这种树脂的组合物（例如胶粘剂）及其用途。更具体地，本发明涉及用于环氧树脂的混合硬化剂，包括芳香胺、酚和/或苯酯基团。本发明的另一个方面涉及具有优异固化潜伏期和低固化温度起始点的新咪唑催化剂。
• METHOD FOR PRODUCING CYANOGEN-HALIDE, CYANATE ESTER COMPOUND AND METHOD FOR PRODUCING THE SAME, AND RESIN COMPOSITION
  申请人：MITSUBISHI GAS CHEMICAL COMPANY, INC.

  公开号：US20150299110A1

  公开（公告）日：2015-10-22

  A method for efficiently producing a cyanogen halide with suppressed side effects, and a method for producing a high-purity cyanate ester compound at a high yield includes contacting a halogen molecule with an aqueous solution containing hydrogen cyanide and/or a metal cyanide, so that the hydrogen cyanide and/or the metal cyanide is allowed to react with the halogen molecule in the reaction solution to obtain the cyanogen halide, wherein more than 1 mole of the hydrogen cyanide or the metal cyanide is used based on 1 mole of the halogen molecule, and when an amount of substance of an unreacted hydrogen cyanide or an unreacted metal cyanide is defined as mole (A) and an amount of substance of the generated cyanogen halide is defined as mole (B), the reaction is terminated in a state in which (A):(A)+(B) is between 0.00009:1 and 0.2:1.

  一种用于高效生产抑制副作用的氰卤化物，以及以高收率生产高纯度氰酸酯化合物的方法包括将卤素分子与含有氢氰酸和/或金属氰化物的水溶液接触，使得氢氰酸和/或金属氰化物与卤素分子在反应溶液中发生反应以获得氰卤化物，其中基于1摩尔卤素分子使用超过1摩尔的氢氰酸或金属氰化物，当未反应的氢氰酸或未反应的金属氰化物的物质量定义为摩尔(A)，生成的氰卤化物的物质量定义为摩尔(B)，反应在(A)：(A)+(B)介于0.00009:1和0.2:1之间的状态中终止。