2-amino-4-benzyloxy-6-methylpyrimidine | 70483-81-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 2-amino-4-benzyloxy-6-methylpyrimidine
• 英文别名: 2-Amino-4-methyl-6-benzyloxipyrimidin；4-benzyloxy-6-methyl-pyrimidin-2-ylamine；2-amino-4-methyl-6-benzyloxypyrimidine；4-methyl-6-phenylmethoxypyrimidin-2-amine
• CAS: 70483-81-7
• 化学式: C₁₂H₁₃N₃O
• 分子量: 215.255
• InChiKey: GIZFKXVQZAUFIA-UHFFFAOYSA-N

物化性质

• 沸点：
  433.5±37.0 °C(Predicted)
• 密度：
  1.201±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  61
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-amino-4-benzyloxy-6-methylpyrimidine 在 乙酸酐 作用下， 以 苯 为溶剂， 生成 2-Acetamido-4-methyl-6-benzyloxipyrimidin
  参考文献：
  名称：

  N-pyrimidinyl-N-dialkylaminoalkyl ureas

  摘要：

  基于尿素分子的有机化合物揭示了具有强效胃酸分泌抑制性能的化合物。尿素被取代为含有2个或3个杂原子的6元杂环取代基，并且还被取代为含有取代氨基烷基基团。进一步的取代也是可能的。这些化合物对胃肠道中胃酸分泌的抑制具有深远影响，并且还公开了用于此类用途的组合物。

  公开号：

  US04144338A1
• 作为产物：
  描述：

  4-benzyloxy-N-[(2,4-dimethoxyphenyl)methyl]-6-methylpyrimidin-2-amine 在 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 以85 %的产率得到2-amino-4-benzyloxy-6-methylpyrimidine
  参考文献：
  名称：

  [EN] PTPN2 INHIBITORS
  [FR] INHIBITEURS DE PTPN2

  摘要：

  The present invention is generally directed to inhibitors of protein tyrosine phosphatase enzymes (PTPN1 and/or PTPN2) useful in the treatment of diseases and disorders modulated by said enzymes and having the Formula (I). Further disclosed a method of treating a disease or disorder associated with PTPN1/PTPN2, comprising of administering to a subject a compound or a pharmaceutical composition.

  公开号：

  WO2023220572A1
• 作为试剂：
  描述：

  2-氨基-4-羟基-6-甲基嘧啶 、 sodium;hydride 、 氯化苄 在 氮气 、 2-amino-4-benzyloxy-6-methylpyrimidine 、 氯丁烷 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 5.25h， 生成 2-amino-4-benzyloxy-6-methylpyrimidine
  参考文献：
  名称：

  N-pyrimidinyl-N-dialkylaminoalkyl ureas

  摘要：

  本发明揭示了一种基于尿素分子的有机化合物，具有强效的胃分泌抑制性能。尿素被6元杂环取代基替换，该取代基含有2或3个杂原子，并且还带有取代的氨基烷基团。进一步的取代也是可能的。这些化合物对胃肠道中胃分泌的抑制具有深远的影响，并且还揭示了用于此类用途的组合物。

  公开号：

  US04144338A1

文献信息

• Pyrazine substituted ureas
  申请人：Merck & Co., Inc.

  公开号：US04215121A1

  公开（公告）日：1980-07-29

  Organic chemical compounds based upon the urea molecule are disclosed which have potent gastric secretion inhibitory properties. The urea is substituted with a 6 membered heterocyclic substituent containing 2 or 3 heteroatoms, and also with a substituted amino alkyl group. Further substitution is also possible. The compounds have profound effects on the inhibition of gastric secretions in the gastro-intestinal tract, and compositions for such uses are also disclosed.

  本发明揭示了基于尿素分子的有机化合物，具有强大的胃分泌抑制作用。尿素被取代为含有2或3个杂原子的6元杂环取代基，并且还被取代为含有取代氨基烷基。此外，还可以进行进一步的取代。这些化合物对于抑制肠道内的胃分泌具有深远的影响，并且还揭示了用于此类用途的组合物。
• Synthesis and biological activity of hydrochlorides of benzyl ethers of pyrimidin-4(3H)-thiones and related compounds
  作者：A. V. Erkin、V. V. Gurzhii、V. I. Krutikov

  DOI：10.1134/s1070363215010144

  日期：2015.1

  Hydrochlorides of benzyl ether of 2-amino-6-methylpyrimidin-4(3H)-thione and its analogs were synthesized and biological activity of the synthesized compounds was studied.
• Synthesis and Self Assembling Properties of Rod-Like, 2-Ureido-4-pyrimidinone-Based Main Chain Supramolecular Dendronized Polymers
  作者：Chun-Ho Wong、Wing-Shong Chan、Chui-Man Lo、Hak-Fun Chow、To Ngai、Ka-Wai Wong

  DOI：10.1021/ma101647j

  日期：2010.10.26

  A series of G1-G3 supramolecular dendronized polymers 6 bearing dimeric 2-ureido-4-pyrimidinone (UPy) units on the main chain and aliphatic hydrocarbon dendrons as side chain appendages was prepared. Because of the high crystallinity and poor solubility of such rigid rod polymers, only the 03 dendron could confer the resulting polymer 6 (n = 3) with enough solubility to enable its characterization and property studies. It was found that the nature of the dendrons play an important role on the UP.,, binding strength, solubility and self-assembly properties. The reversible nature of the polymerization process was demonstrated in different solvent systems by viscosity studies. A double logarithmic plot of the specific viscosity against concentration revealed a deflection point at 26 mM in CHCl3 at 26 and 40 degrees C. Below this critical concentration a straight line with a slope of 1.5 was obtained, while a slope of 4.0-4.2 was secured above this concentration. The data suggested that the associative interaction between the di-UPy monomer 5 (n = 3) increased nonlinearly with increasing monomer concentration. While the above investigations confirmed that these were main chain supramolecular dendronized polymers, UV-vis spectroscopic study revealed a large bathochromic shift (32 nm) with increasing polymer concentration in CHCl3. This finding was consistent with the formation of J-type aggregates via stair-case stacking between interchain UPy rings. SEM morphological study also confirmed that the resulting polymers appeared as fibrous superbundles with a very high aspect ratio. A model was purposed to rationalize how such bundles could be assembled from the di-UPy dendritic macromonomer 5 via intrachain hydrogen bonding and interchain stacking interactions.
• US4144338A
  申请人：——

  公开号：US4144338A

  公开（公告）日：1979-03-13
• US4215121A
  申请人：——

  公开号：US4215121A

  公开（公告）日：1980-07-29