5-hexyl-2-oxotetrahydrofuran-3-carboxylic acid methyl ester | 154714-35-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酯类
• 英文名称: 5-hexyl-2-oxotetrahydrofuran-3-carboxylic acid methyl ester
• 英文别名: dihydro-3-(carboxymethyl)-5-hexyl-2(3H)-furanone；α-methoxycarbonyl-γ-hexyl-γ-butyrolactone；alpha-Methoxycarbonyl-gamma-hexyl-gamma-butyrolactone；methyl 5-hexyl-2-oxooxolane-3-carboxylate
• CAS: 154714-35-9
• 化学式: C₁₂H₂₀O₄
• 分子量: 228.288
• InChiKey: LQLLBUOIMHVXME-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  16
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  丙二酸二甲酯 、 辛烯 、 氧气 、 dimethyl 2-(2-oxooctyl)malonate 、 5-hexyl-2-oxotetrahydrofuran-3-carboxylic acid methyl ester 在 manganese(II) acetate 、 Zirconium glycolate 氮气 作用下， 以 溶剂黄146 为溶剂， 90.0 ℃ 、13.47 MPa 条件下， 反应 3.0h， 生成 dimethyl octylmalonate 、 dimethyl 2-(2-hexyldecyl)malonate
  参考文献：
  名称：

  Process for the preparation of organic compounds with manganese catalysts or the like

  摘要：

  本发明的过程通过催化自由基加成反应，高效地产生具有烷基或烯基在电子引力基团的α位上键合的化合物或其衍生物。该过程将具有如规范中定义的式（1）的电子引力基团的化合物与具有如规范中定义的式（2）或（7）的不饱和碳碳键的化合物反应，以生产如规范中定义的式（3）或（8）的化合物。本发明的特点在于在氧气和元素周期表的第7、8或9组元素的催化化合物的存在下进行反应。

  公开号：

  US06548713B2
• 作为产物：
  描述：

  辛烯 在 溶剂黄146 、 锌 作用下， 以 四氢呋喃 、 水 、 1,2-二氯乙烷 为溶剂， 反应 78.0h， 生成 5-hexyl-2-oxotetrahydrofuran-3-carboxylic acid methyl ester
  参考文献：
  名称：

  分子间自由基加成和烷氧基胺在未活化的烯烃上的加成/环化反应。

  摘要：

  [反应：见正文]烷氧基胺A（很容易从市售的起始原料制得）在各种未活化的烯烃上进行有效的热自由基碳氨羰基化反应，以良好的产率获得良​​好的1,4-官能化的丙二酸酯B。实验非常容易进行。羧甲基化可以与自由基环化和断裂过程结合。

  DOI：

  10.1021/ol034994k

文献信息

• Sonochemical lactonization of olefins with ceric ammonium nitrate and monomethyl ester of malonic acid
  作者：Andrea D'Annibale、Corrado Trogolo

  DOI：10.1016/s0040-4039(00)73056-5

  日期：1994.3

  Lactonization of olefins with monomethyl ester of malonic acid and ceric ammonium nitrate was carried out in acetic acid and in acetonitrile under simple mechanical stirring or ultrasound irradiation. Comparative results are reported; for activated olefins a good ultrasonic acceleration was observed.

  在简单的机械搅拌或超声辐射下，在乙酸和乙腈中，用丙二酸和硝酸硝酸铈铵的单甲酯对烯烃进行酯化。报告了比较结果；对于活性烯烃，观察到良好的超声加速。
• Process for the preparation of organic compounds with manganese cataylsts or the like
  申请人：——

  公开号：US20020165416A1

  公开（公告）日：2002-11-07

  A process of the present invention produces an organic compound by allowing a compound containing an electron attractive group of following Formula (1): 1 wherein Y is an electron attractive group; and R b and R c are each a hydrogen atom or an organic group, where Y, R b and R c may respectively be combined with each other to form a ring with an adjacent carbon atom, to react with a compound containing an unsaturated carbon-carbon bond of following Formula (2) or 2 wherein R d , R e , R f , R g , R i and R j are each a hydrogen atom or an organic group, where R d , R e , R f and R g may respectively be combined to form a ring with one or two adjacent carbon atoms, and R i and R j may be combined to form a ring with adjacent two carbon atoms, in the presence of oxygen and a catalytic compound of a Group 5, 6, 7, 8 or 9 element of the Periodic Table of Elements to yield a compound of following Formula (3) or (8): 3 wherein Z is a hydrogen atom or a hydroxyl group; and Y, R b , R c , R d , R e , R f , R g , R i and R j have the same meanings as defined above. This process can efficiently produce a compound having an alkyl group or alkenyl group bonded at the alpha position of an electron attractive group, or a derivative thereof, by catalytic radical addition reaction.

  本发明的一种过程通过允许含有下式（1）中的电子亲合基团的化合物与含有下式（2）的不饱和碳-碳键的化合物在氧气和周期表元素的5、6、7、8或9族的催化化合物存在下反应，产生下式（3）或（8）的化合物： 其中Y是一个电子亲合基团；Rb和Rc分别是氢原子或有机基团，其中Y、Rb和Rc可以分别结合在一起形成与相邻碳原子的环；Rd、Re、Rf、Rg、Ri和Rj分别是氢原子或有机基团，其中Rd、Re、Rf和Rg可以分别结合在一起形成与一个或两个相邻碳原子的环，而Ri和Rj可以结合在一起形成与相邻两个碳原子的环。这个过程可以通过催化自由基加成反应高效地产生在电子亲合基团的α位结合有烷基或烯基基团的化合物，或其衍生物。
• HAIR TREATMENT COMPOSITION AND HAIR COSMETIC FOR DAMAGED HAIR
  申请人：Meiji Seika Kaisha, Ltd.

  公开号：EP1602354A1

  公开（公告）日：2005-12-07

  The present invention intends to provide a composition for hair treatment containing γ-polyglutamic acid or a salt thereof, a hair cosmetic for damaged hair containing such a composition, and their uses. The composition for hair treatment containing γ-polyglutamic acid or a salt thereof and the hair cosmetic for damaged hair of the present invention have excellent improvement effects on the strength and frictional force of hair, so that they can provide tension, elasticity, or the like to damage hair to prevent or alleviate split hair and broken hair as well as improvements in combing and touch. Furthermore, they also exert effects of moisture retention inherent to γ-polyglutamic acid or a salt thereof, preventing or improving effects on the generation of dandruff on the basis of such effects, preventing effects on the feeling of stickiness or creak, and various effectiveness including appropriate residual tendency to hair in a simultaneous manner, respectively.

  本发明旨在提供一种含有γ-聚谷氨酸或其盐的头发治疗组合物、一种含有这种组合物的用于受损头发的护发化妆品及其用途。本发明的含有γ-聚谷氨酸或其盐的头发治疗组合物和用于受损头发的护发化妆品对头发的强度和摩擦力有很好的改善效果，因此它们可以为受损头发提供张力、弹性等，以防止或减轻头发分叉和断裂，并改善梳理和触感。此外，它们还能分别发挥γ-聚谷氨酸或其盐固有的保湿效果、在此基础上防止或改善头皮屑产生的效果、防止粘腻感或吱吱作响的效果，以及包括同时对头发产生适当残留倾向在内的各种功效。
• Cosmetic composition and production thereof
  申请人：Kawasaki Yuji

  公开号：US20060018867A1

  公开（公告）日：2006-01-26

  It has been desired to develop a highly preservative and antibacterial cosmetic composition that can easily be applied to both emulsion and non-emulsion type cosmetics. It has also been desired to develop a method of improving a preservative and/or antibacterial effect(s) of a cosmetic composition comprising polyorganosiloxane-containing epsilon-polylysine and thereby reducing the amount of antibacterial preservative agent to be used. There is provided a cosmetic composition comprising one or a combination of two or more of polyorganosiloxane-containing epsilon-polylysine compounds obtained by reacting epsilon-polylysine with polyorganosiloxane or a physiologically acceptable salt thereof, and polyhydric alcohol.

  人们一直希望开发一种高防腐性和抗菌性的化妆品组合物，这种组合物既可用于乳液型化妆品，也可用于非乳液型化妆品。此外，还希望开发一种方法，以改善含有聚有机硅氧烷的ε-聚赖氨酸的化妆品组合物的防腐和/或抗菌效果，从而减少抗菌防腐剂的用量。本发明提供了一种化妆品组合物，该组合物包含一种或两种以上的含聚有机硅氧烷的ε-聚赖氨酸化合物的组合，这些ε-聚赖氨酸化合物是通过ε-聚赖氨酸与聚有机硅氧烷或其生理上可接受的盐以及多元醇反应而得到的。
• Hair treatment composition and hair cosmetic for damaged hair
  申请人：Hasebe Kouhei

  公开号：US20060165636A1

  公开（公告）日：2006-07-27

  The present invention intends to provide a composition for hair treatment containing γ-polyglutamic acid or a salt thereof, a hair cosmetic for damaged hair containing such a composition, and their uses. The composition for hair treatment containing γ-polyglutamic acid or a salt thereof and the hair cosmetic for damaged hair of the present invention have excellent improvement effects on the strength and frictional force of hair, so that they can provide tension, elasticity, or the like to damage hair to prevent or alleviate split hair and broken hair as well as improvements in combing and touch. Furthermore, they also exert effects of moisture retention inherent to γ-polyglutamic acid or a salt thereof, preventing or improving effects on the generation of dandruff on the basis of such effects, preventing effects on the feeling of stickiness or creak, and various effectiveness including appropriate residual tendency to hair in a simultaneous manner, respectively.

  本发明旨在提供一种含有γ-聚谷氨酸或其盐的头发治疗组合物、一种含有这种组合物的用于受损头发的护发化妆品及其用途。本发明的含有γ-聚谷氨酸或其盐的头发治疗组合物和用于受损头发的护发化妆品对头发的强度和摩擦力有很好的改善效果，因此它们可以为受损头发提供张力、弹性等，以防止或减轻头发分叉和断裂，并改善梳理和触感。此外，它们还能分别发挥γ-聚谷氨酸或其盐固有的保湿效果、在此基础上防止或改善头皮屑产生的效果、防止粘腻感或吱吱作响的效果，以及包括同时对头发产生适当残留倾向在内的各种功效。