7-(1,3-dioxan-2-yl)-heptan-1-ol | 783367-43-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 7-(1,3-dioxan-2-yl)-heptan-1-ol
• 英文别名: 7-(1,3-dioxan-2-yl)heptanol；7-(1,3-Dioxan-2-yl)heptan-1-ol
• CAS: 783367-43-1
• 化学式: C₁₁H₂₂O₃
• 分子量: 202.294
• InChiKey: PCGXTTVVCFUEDV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  14
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  38.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  7-(1,3-dioxan-2-yl)-heptan-1-ol 在 甲醇 、 N-碘代丁二酰亚胺 、 三氟甲磺酸 、 sodium methylate 、 溶剂黄146 、 乙二胺 作用下， 以 四氢呋喃 、 乙醇 、 二氯甲烷 、 水 为溶剂， 反应 96.0h， 生成
  参考文献：
  名称：

  Preparation of synthetic oligosaccharide-conjugates of poly-β-(1→6)-N-acetyl glucosamine

  摘要：

  Staphylococcus aureus and Staphylococcus epidermidis are prominent bacterial pathogens of nosocomial infections. Both microorganisms colonize medical devices by forming adherent biofilms. poly-beta-(1 -> 6)-N-acetyl-glucosamine (PNAG) is a surface polysaccharide antigen which was found on both S. aureus and S. epidermidis. Animal studies have proved that PNAG can elicit antibodies which protect against staphylococcal infections. We have presented the synthesis of di-, tetra-and hexasaccharide fragments of PNAG with formyl-heptyl aglycone and their attachment to bovine serum albumin (BSA) by reductive amination. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.carres.2013.12.022
• 作为产物：
  描述：

  1,8-辛二醇 在 草酰氯 、 4 A molecular sieve 、 四丁基氟化铵 、 对甲苯磺酸 、 二甲基亚砜 、 N,N-二异丙基乙胺 作用下， 以 四氢呋喃 、 正己烷 、 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 14.75h， 生成 7-(1,3-dioxan-2-yl)-heptan-1-ol
  参考文献：
  名称：

  Synthesis of oligogalacturonates conjugated to BSA

  摘要：

  The synthesis of three oligogalacturonates with an aldehyde spacer attached at the reducing end is described. Trigalacturonates alpha-D-GalpA-(1-->4)-alpha-D-GalpA-(1-->4)-alpha-D-GalpA-(1-->O(CH2)(7)CHO and alpha-D-GalpA(Me)-(1-->4)-alpha-D-GalpA(Me)(1-->4)-alpha-D-GalpA(Me)-(1--> O(CH2)(7)CHO as well as hexagalacturonate alpha-D-GalpA-(1-->4)-[alpha-D-GalpA-(14)](4)-alpha-D-GalpA(1-->O(CH2)(7)CHO are prepared by stepwise coupling of galactose units followed by oxidation of the 6-positions. The alpha-linkages are formed by employing n-pentenyl galactosides as glycosyl donors and N-iodosuccinimide/triethylsilyl triflate as the promoter. Deprotection furnishes the three target oligogalacturonates, which are subsequently linked to bovine serum albumin by reductive amination. These neoglycoproteins will serve as immunogens for generation of new antibodies that can be used for localization and characterization of pectin in plants. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.carres.2004.06.012

文献信息

• Synthesis of S-Linked N-Acetylneuraminic Acid Derivatives via Photoinduced Thiol-ene and Thiol-yne Couplings
  作者：Magdolna Csávás、Anikó Borbás、Mihály Herczeg

  DOI：10.1055/s-0032-1318480

  日期：——

  Thio-linked mono-and bivalent mimetics of alpha(2 -> 3) and alpha(2 -> 6)-linked sialosides were prepared by photoinduced hydrothiolation of alkenes and alkynes with the 2-mercapto sialic acid. Thiosialylation of 6-O-allyl- or 3-O-allyl-substituted galactose derivatives has been carried out by the thiol-ene click reaction. Double thiosialylation has also been achieved via thiol-yne chemistry using propargylated galactose derivatives as the alkyne components and the peracetylated 2-mercapto sialic acid as the thiol.