(10S,13S)-5-hexyl-13-[(1S)-1-hydroxyethyl]-9-methyl-10-propan-2-yl-3-oxa-9,12-diazatricyclo[6.6.1.04,15]pentadeca-1,4,6,8(15)-tetraen-11-one | 168335-69-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (10S,13S)-5-hexyl-13-[(1S)-1-hydroxyethyl]-9-methyl-10-propan-2-yl-3-oxa-9,12-diazatricyclo[6.6.1.04,15]pentadeca-1,4,6,8(15)-tetraen-11-one
• CAS: 168335-69-1
• 化学式: C₂₄H₃₆N₂O₃
• 分子量: 400.561
• InChiKey: UCFDLQKAGHRYLF-BPXKWBHBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6
• 重原子数：
  29
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  65.7
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (10S,13S)-5-hexyl-13-[(1S)-1-hydroxyethyl]-9-methyl-10-propan-2-yl-3-oxa-9,12-diazatricyclo[6.6.1.04,15]pentadeca-1,4,6,8(15)-tetraen-11-one 在 氢氧化钾 、 三苯基膦 、 偶氮二甲酸二乙酯 作用下， 以 四氢呋喃 、 乙醇 为溶剂， 反应 41.0h， 生成 <2S-<2R*,5R*(S*)>>-9-hexyl-1,2,5,6-tetrahydro-5-(1-hydroxyethyl)-1-methyl-2-(1-methylethyl)furo<4,3,2-gh>-1,4-benzodiazonin-3(4H)-one
  参考文献：
  名称：

  Effect of Alteration of the Heterocyclic Nucleus of Indolactam V on Its Isoform Selectivity for PKC. Palladium-Catalyzed Route to Benzofuran Analogs of ILV

  摘要：

  The discovery of isoform-selective modulators of protein kinase C (PKC) appears worthwhile in further defining the roles of the individual PKC isoforms in cell type-specific processes. In comparison with the phorbol esters, little information is available regarding the isoform selectivity of the teleocidin family. Blumberg has reported recently that 7-n-octylindolactam V exhibits little if any selectivity for the isoforms tested. In order to probe the possibility of developing isotype-selective agents based on the indolactam V (ILV) structure, we sought to explore replacement of the indole nucleus by a benzofuran ring. Herein we describe a novel palladium-catalyzed route to four benzofuran analogues 11a-d of ILV together with details of their isoform selectivity. Of considerable interest is the unexpected finding that this subtle N to O structural change leads to a compound (11b) that is modestly more like 12,13-dibutyrate phorbol and less like n-octyl-ILV in its pattern of activity. Moreover, the effect of introducing an additional stereocenter at C-14 into these benzofurans was explored, and a clear preference for R-stereochemistry at the C-14 center of the teleocidin family was found, thus providing additional verification of previously published structural correlations between the families of PKC activators. Overall, the present findings provide an important new direction in the quest for isoform-selective activators of PKC.

  DOI：

  10.1021/ja00130a003
• 作为产物：
  描述：

  N-(2-Bromo-4-hexanoyl-3-hydroxy-phenyl)-2,2-dimethyl-propionamide 在 palladium on activated charcoal N-甲基吗啉 、 2,6-二甲基吡啶 、 盐酸 、 sodium tetrahydroborate 、 四丁基氯化铵 、 水 、 氢气 、 sodium formate 、 palladium diacetate 、 氯甲酸乙酯 、 sodium cyanoborohydride 、 sodium carbonate 、 (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate 、 1-羟基苯并三唑 、 三乙胺 、 三苯基膦 、 三氟乙酸 、 偶氮二甲酸二乙酯 作用下， 以 四氢呋喃 、 乙醇 、 水 、 1,2-二氯乙烷 、 N,N-二甲基甲酰胺 、 乙腈 为溶剂， 80.0 ℃ 、101.33 kPa 条件下， 反应 81.5h， 生成 (10S,13S)-5-hexyl-13-[(1S)-1-hydroxyethyl]-9-methyl-10-propan-2-yl-3-oxa-9,12-diazatricyclo[6.6.1.04,15]pentadeca-1,4,6,8(15)-tetraen-11-one
  参考文献：
  名称：

  Effect of Alteration of the Heterocyclic Nucleus of Indolactam V on Its Isoform Selectivity for PKC. Palladium-Catalyzed Route to Benzofuran Analogs of ILV

  摘要：

  The discovery of isoform-selective modulators of protein kinase C (PKC) appears worthwhile in further defining the roles of the individual PKC isoforms in cell type-specific processes. In comparison with the phorbol esters, little information is available regarding the isoform selectivity of the teleocidin family. Blumberg has reported recently that 7-n-octylindolactam V exhibits little if any selectivity for the isoforms tested. In order to probe the possibility of developing isotype-selective agents based on the indolactam V (ILV) structure, we sought to explore replacement of the indole nucleus by a benzofuran ring. Herein we describe a novel palladium-catalyzed route to four benzofuran analogues 11a-d of ILV together with details of their isoform selectivity. Of considerable interest is the unexpected finding that this subtle N to O structural change leads to a compound (11b) that is modestly more like 12,13-dibutyrate phorbol and less like n-octyl-ILV in its pattern of activity. Moreover, the effect of introducing an additional stereocenter at C-14 into these benzofurans was explored, and a clear preference for R-stereochemistry at the C-14 center of the teleocidin family was found, thus providing additional verification of previously published structural correlations between the families of PKC activators. Overall, the present findings provide an important new direction in the quest for isoform-selective activators of PKC.

  DOI：

  10.1021/ja00130a003

文献信息

• Kozikowski; Ma; Du, Il Farmaco, 1995, vol. 50, # 6, p. 425 - 430
  作者：Kozikowski、Ma、Du、Lewin、Blumberg

  DOI：——

  日期：——