N-hexylquinolin-6-amine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: N-hexylquinolin-6-amine
• 化学式: C₁₅H₂₀N₂
• mdl: MFCD18002895
• 分子量: 228.337
• InChiKey: AHKGANDHBFCVKF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  17
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  24.9
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N-hexylquinolin-6-amine 、 氯化苄 生成 1-benzyl-6-hexylamino-quinolinium; chloride
  参考文献：
  名称：

  DE745559

  摘要：

  公开号：
• 作为产物：
  描述：

  6-溴喹啉 、 正己胺 在 copper(I) oxide 、 N¹-benzyl-N²-(2-methylnaphthalen-1-yl)oxalamide 、 potassium hydroxide 作用下， 以 乙醇 为溶剂， 反应 12.0h， 以82%的产率得到N-hexylquinolin-6-amine
  参考文献：
  名称：

  Discovery of N-(Naphthalen-1-yl)-N′-alkyl Oxalamide Ligands Enables Cu-Catalyzed Aryl Amination with High Turnovers

  摘要：

  A Class of N-(naphthalen-1-yl)-N'-alkyl oxalamides have been proven to be powerful ligands, making a coupling reaction of (hetero)aryl iodides with primary amines proceed at 50 degrees C with only 0.01 mol % of Cu2O and ligand as well as a coupling reaction of (hetero)aryl bromides with primary amines and ammonia at 80 degrees C with only 0.1 mol % of Cu2O and ligand. A wide range of coupling partners work well under these conditions thereby providing an easy to operate method for preparing (hetero)atyl amines.

  DOI：

  10.1021/acs.orglett.7b00901

文献信息

• Smiles Rearrangement Based Practical One-pot Synthesis of N-Alkyl/aryl-6-aminoquinolines from 6-Hydroxylquinoline
  作者：Yong-Sheng Xie、B.V.D. Vijaykumar、Kiwan Jang、Kyung-Min Choi、Hua Zuo、Yong-Jin Yoon、Dong-Soo Shin

  DOI：10.5012/bkcs.2013.34.12.3881

  日期：2013.12.20
• DE745559
  申请人：——

  公开号：——

  公开（公告）日：——
• Discovery of <i>N</i>-(Naphthalen-1-yl)-<i>N</i>′-alkyl Oxalamide Ligands Enables Cu-Catalyzed Aryl Amination with High Turnovers
  作者：Jie Gao、Subhajit Bhunia、Kailiang Wang、Lu Gan、Shanghua Xia、Dawei Ma

  DOI：10.1021/acs.orglett.7b00901

  日期：2017.6.2

  A Class of N-(naphthalen-1-yl)-N'-alkyl oxalamides have been proven to be powerful ligands, making a coupling reaction of (hetero)aryl iodides with primary amines proceed at 50 degrees C with only 0.01 mol % of Cu2O and ligand as well as a coupling reaction of (hetero)aryl bromides with primary amines and ammonia at 80 degrees C with only 0.1 mol % of Cu2O and ligand. A wide range of coupling partners work well under these conditions thereby providing an easy to operate method for preparing (hetero)atyl amines.
• US2152047
  申请人：——

  公开号：——

  公开（公告）日：——