acrylohydrazide | 3128-32-3

• 物质功能分类: 有机原料 - 氨基化合物
• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: acrylohydrazide
• 英文别名: acrylohydrazone；acrylhydrazide；Acrylohydrazid；acryloyl hydrazine；2-methyleneacethydrazide；acrylic acid hydrazide；Acrylsaeure-hydrazid；Acryloylhydrazin；amino acrylamide；2-Propenoic acid, hydrazide；prop-2-enehydrazide
• CAS: 3128-32-3
• 化学式: C₃H₆N₂O
• mdl: MFCD14155854
• 分子量: 86.0934
• InChiKey: KJASTBCNGFYKSR-UHFFFAOYSA-N

物化性质

• 密度：
  1.040±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  6
• 可旋转键数：
  1
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  55.1
• 氢给体数：
  2
• 氢受体数：
  2

安全信息

• 海关编码：
  2928000090

反应信息

• 作为反应物：
  描述：

  acrylohydrazide 以35%的产率得到
  参考文献：
  名称：

  KASAHARA A., CHEM. AND IND. , 1976, NO 23, 1032

  摘要：

  DOI：
• 作为产物：
  描述：

  丙烯酸钾 生成 acrylohydrazide
  参考文献：
  名称：

  Synthesis of α,β-Unsaturated Carboxylic Hydrazides

  摘要：

  DOI：

  10.1246/bcsj.41.2521

文献信息

• Process for preparing N,N-disubstituted acid hydrazides
  申请人：Uniroyal, Inc.

  公开号：US03965174A1

  公开（公告）日：1976-06-22

  A process for preparing N',N'-disubstituted acid hydrazides by reacting N'-monosubstituted acid hydrazides with aldehydes in the presence of hydrogen and a hydrogenation catalyst is disclosed.

  揭示了一种通过在氢气和氢化催化剂存在下，将N'-单取代酸腙与醛反应制备N',N'-二取代酸腙的方法。
• Acyl Hydrazides: Potent Antioxidants
  作者：Khalid Mohammed Khan、Mubeen Rani、Nida Ambreen、Asma Ejaz、Shahnaz Perveen、Syed Moazzam Haider、Mohammad Iqbal Choudhary、Wolfgang Voelter

  DOI：10.2174/157018012799079798

  日期：2012.2.1

  Twenty-eight acyl hydrazides (1-28) are subjected for nitric oxide scavenging activities and their structureactivity relationship (SAR) is established. Compounds 1-28 showed a varying degree of activity having IC50 values in the range of 9.1 ± 6.5 - 231.1 μM. It was found that twenty-five (25) out of twenty-eight (28) compounds, showed an excellent nitric oxide scavenging activity. It was observed that the activity mainly depends on the substitution on acyl hyrazide moiety. 3-Propylpyrozole-5-carbohydrazide (27) was found to be the most active in the series with an IC50 value of 9.1 μM. Thus, compound 27 may serve as a lead compound for further development as potent antioxidant agent.

  二十八种酰肼类化合物（1-28）被用于研究其对一氧化氮的清除活性，并建立了其构效关系（SAR）。化合物1-28表现出不同程度的活性，其IC50值范围在9.1±6.5至231.1μM之间。研究发现，在二十八种（28）化合物中，有二十五种（25）展现出了优秀的一氧化氮清除活性。观察到活性主要取决于酰肼部分的取代基。其中，3-丙基吡唑-5-甲酰肼（27）被发现是该系列中最具活性的化合物，其IC50值为9.1μM。因此，化合物27可能作为潜在的抗氧化剂进一步开发研究的先导化合物。
• Blue-light-emitting iridium complex, iridium complex monomer, phosphorus polymer, and organic electroluminescence device using same
  申请人：Lee Jae-Suk

  公开号：US09150601B2

  公开（公告）日：2015-10-06

  Provided are a blue-light-emitting iridium complex, an iridium complex monomer, a phosphorescent polymer, and an organic electroluminescent device using same. The blue-light-emitting iridium complex contains a ligand having a low electron density structure, such as triazole or tetrazole. The iridium complex monomer containing a ligand having a polymerizable vinyl group produces a blue phosphorescent polymer through the polymerization with carbazole derivatives. The organic electroluminescent device comprises a first electrode, a second electrode, and a light-emitting layer interposed between the first electrode and the second electrode, wherein the light-emitting layer contains the above-described iridium complex or polymer containing the iridium complex.

  提供了一种发蓝光的铱配合物、一种铱配合物单体、一种磷光聚合物，以及使用它们的有机电致发光器件。这种发蓝光的铱配合物包含具有低电子密度结构的配体，如三唑或四唑。含有可聚合乙烯基团的配体的铱配合物单体通过与咔唑衍生物聚合产生蓝色磷光聚合物。有机电致发光器件包括第一电极、第二电极和位于第一电极和第二电极之间的发光层，其中发光层含有上述铱配合物或含有铱配合物的聚合物。
• Photostable and Orthogonal Solvatochromic Fluorophores for Simultaneous <i>In Situ</i> Quantification of Multiple Cellular Signaling Molecules
  作者：Ashutosh Sharma、Jiachen Sun、Indira Singaram、Arthur Ralko、Daesung Lee、Wonhwa Cho

  DOI：10.1021/acschembio.0c00241

  日期：2020.7.17

  fluorescence sensors are powerful tools for direct quantification of diverse biological analytes. To overcome a shortage of solvatochromic fluorophores crucial for in situ ratiometric imaging of biological targets, we prepared and characterized a small library of modular fluorophores with diverse spectral properties. Among them, WCB and WCR showed excellent spectral properties, including high photostability

  比率荧光传感器是直接定量分析各种生物分析物的强大工具。为了克服对于生物靶标原位成比例成像至关重要的溶剂变色荧光团的不足，我们制备并表征了一个小型的具有各种光谱特性的模块化荧光团库。其中，WCB和WCR具有出色的光谱特性，包括高光稳定性，亮度和溶剂致变色性，并且由于它们的光谱正交性而非常适合于双比例成像。通过将WCB和WCR与基于蛋白质的脂质传感器结合，我们能够实现强大的原位同步活细胞中两种代谢相关的信号传导脂质磷脂酰肌醇-4,5-双磷酸和磷脂酰肌醇-3,4,5-三磷酸的定量成像。这项研究表明，信号分子的任何组合都可以通过时空分辨的方式通过比例成像和精细调整的溶剂化变色荧光团同时进行定量。
• Polymer complexes. LVI. Supramolecular architectures consolidated by hydrogen bonding and π–π interaction
  作者：A.A. El-Bindary、A.Z. El-Sonbati、M.A. Diab、M.E. Attallah

  DOI：10.1016/j.saa.2011.11.009

  日期：2012.2

  The amidation of aliphatic amine with acryloyl chloride in dry benzene as a solvent has been performed. Moreover, the polymer complexes have been prepared and structurally characterized by analyses, molar conductance measurements, magnetic susceptibility measurements, spectral techniques like IR. UV, NMR, ESR and thermal methods. Acryloyl hydrazine (AH) has been shown to behave as a bidentate ligand via its nitrogen (NH2 of hydrazine group) and C-O/C=O (acryloyl group) in polymer complexes, all of which exhibit supramolecular architectures assembled through weak interaction including hydrogen bonding and pi-pi stacking The magnetic and spectral data indicate a square planar geometry for Cu2+ complexes and an octahedral geometry for Co(II) and UO2(II). The ESR spectral data of the Cu(II) complexes showed that the metal-ligand bonds have considerable covalent character. The thermal stability was investigated using thermogravirnetric analysis. The results showed that the polymer complexes are more stable than the homopolymer. (C) 2011 Elsevier B.V. All rights reserved.