1-((1R,2S,5R)-2-Isopropyl-5-methyl-cyclohexyl)-phosphetane 1-sulfide | 188981-88-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 1-((1R,2S,5R)-2-Isopropyl-5-methyl-cyclohexyl)-phosphetane 1-sulfide
• CAS: 188981-88-6
• 化学式: C₁₃H₂₅PS
• 分子量: 244.381
• InChiKey: RBLJMIKMNFWSPR-FRRDWIJNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.33
• 重原子数：
  15.0
• 可旋转键数：
  2.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  0.0
• 氢给体数：
  0.0
• 氢受体数：
  1.0

反应信息

• 作为反应物：
  描述：

  溴甲苯 、 1-((1R,2S,5R)-2-Isopropyl-5-methyl-cyclohexyl)-phosphetane 1-sulfide 在 仲丁基锂 作用下， 生成 (1S,2R)-2-Benzyl-1-((1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl)-phosphetane 1-sulfide 、 (1R,2S)-2-Benzyl-1-((1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl)-phosphetane 1-sulfide
  参考文献：
  名称：

  Synthesis and α-alkylation of 1-menthylphosphetane sulfide

  摘要：

  1-Menthylphosphetan sulfide, 5, has been prepared from menthylphosphine and 1-bromo-3-chloropropane via the corresponding phosphetane-borane complex. The metalation-substitution reactions of both intracyclic alpha carbon atoms of 5 with benzyl and/or trimethylsilyl groups have been examined with regard to stereochemistry. The diastereoselectivity of these reactions is high enough to allow a preparative access to new chiral phosphetane sulfides. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4020(97)00132-4
• 作为产物：
  描述：

  (-)-menthylphosphine 在 1,2,3,4,5,6,7,8-八硫杂环辛烷 、 dimethyl sulfide borane 、 三乙胺 作用下， 生成 1-((1R,2S,5R)-2-Isopropyl-5-methyl-cyclohexyl)-phosphetane 1-sulfide
  参考文献：
  名称：

  Synthesis and α-alkylation of 1-menthylphosphetane sulfide

  摘要：

  1-Menthylphosphetan sulfide, 5, has been prepared from menthylphosphine and 1-bromo-3-chloropropane via the corresponding phosphetane-borane complex. The metalation-substitution reactions of both intracyclic alpha carbon atoms of 5 with benzyl and/or trimethylsilyl groups have been examined with regard to stereochemistry. The diastereoselectivity of these reactions is high enough to allow a preparative access to new chiral phosphetane sulfides. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4020(97)00132-4