methyl 3-O-benzyl-2,6-dideoxy-2,6-imino-α-D-mannofuranoside | 105285-30-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: methyl 3-O-benzyl-2,6-dideoxy-2,6-imino-α-D-mannofuranoside
• 英文别名: (1S,4R,5R,7S,8R)-7-methoxy-8-phenylmethoxy-6-oxa-2-azabicyclo[3.2.1]octan-4-ol
• CAS: 105285-30-1
• 化学式: C₁₄H₁₉NO₄
• 分子量: 265.309
• InChiKey: CNXGFXJIAULZEQ-ITGHMWBKSA-N

物化性质

• 沸点：
  425.1±45.0 °C(Predicted)
• 密度：
  1.25±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  60
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  二碳酸二叔丁酯 、 methyl 3-O-benzyl-2,6-dideoxy-2,6-imino-α-D-mannofuranoside 以 吡啶 为溶剂， 反应 0.5h， 生成 methyl N-t-butyloxycarbonyl-O-benzyl-2,6-dideoxy-2,6-imino-α-D-mannofuranoside
  参考文献：
  名称：

  Methyl 2-azido-3-O-benzyl-2-deoxy-α-D-mamnofuranoside as a divergent intermediate for the synthesis of polyhydroxylated piperidines and pyrrolidines: synthesis of 2,5-dideoxy-2,5-imino-D-mannitol [2R,5R-dihydroxymethyl-3R,4R-dihydroxypyrrolidine]

  摘要：

  DOI：

  10.1016/s0040-4020(01)90034-1
• 作为产物：
  描述：

  3-O-benzyl-1,2-O-isopropylidene-α-D-glucofuranose-5,6-carbonate 在 钯 吡啶 、 sodium azide 、 acid resin (Dowex 50W-XH) 、 氢气 、 sodium methylate 、 对甲苯磺酰氯 作用下， 以 吡啶 、 甲醇 、 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 78.25h， 生成 methyl 3-O-benzyl-2,6-dideoxy-2,6-imino-α-D-mannofuranoside
  参考文献：
  名称：

  Methyl 2-azido-3-O-benzyl-2-deoxy-α-D-mamnofuranoside as a divergent intermediate for the synthesis of polyhydroxylated piperidines and pyrrolidines: synthesis of 2,5-dideoxy-2,5-imino-D-mannitol [2R,5R-dihydroxymethyl-3R,4R-dihydroxypyrrolidine]

  摘要：

  DOI：

  10.1016/s0040-4020(01)90034-1

文献信息

• Treatment of energy utilization disease
  申请人：Vida Pharma Limited

  公开号：US10842784B2

  公开（公告）日：2020-11-24

  Described are compositions comprising imino sugar acids for the treatment of energy utilization disease (e.g. metabolic syndrome, including any disease or disorder associated therewith, for example central obesity, elevated levels of triglycerides and diabetes, including type 1 diabetes, type 2 diabetes and insulin resistance), processes for producing said compositions from various plant sources, together with various products, compounds, compositions, medical uses and methods based thereon.

  所描述的是包含亚氨基糖酸的组合物，用于治疗能量利用疾病（例如代谢综合征，包括与之相关的任何疾病或紊乱，例如中心性肥胖、甘油三酯水平升高和糖尿病，包括 1 型糖尿病、2 型糖尿病和胰岛素抵抗）；从各种植物来源生产所述组合物的工艺，以及基于此的各种产品、化合物、组合物、医疗用途和方法。
• TREATMENT OF ENERGY UTILIZATION DISEASE
  申请人：Summit Corporation Plc

  公开号：EP2257286B1

  公开（公告）日：2016-12-28
• Treatment of Energy Utilization Disease
  申请人：Nash Robert James

  公开号：US20110015226A1

  公开（公告）日：2011-01-20

  Described are compositions comprising imino sugar acids for the treatment of energy utilization disease (e.g. metabolic syndrome, including any disease or disorder associated therewith, for example central obesity, elevated levels of triglycerides and diabetes, including type 1 diabetes, type 2 diabetes and insulin resistance), processes for producing said compositions from various plant sources, together with various products, compounds, compositions, medical uses and methods based thereon.
• [EN] TREATMENT OF ENERGY UTILIZATION DISEASE<br/>[FR] TRAITEMENT D'UNE MALADIE DE L'UTILISATION D'ÉNERGIE
  申请人：SUMMIT CORP PLC

  公开号：WO2009103953A1

  公开（公告）日：2009-08-27

  Described are compositions comprising imino sugar acids for the treatment of energy utilization disease (e.g. metabolic syndrome, including any disease or disorder associated therewith, for example central obesity, elevated levels of triglycerides and diabetes, including type 1 diabetes, type 2 diabetes and insulin resistance), processes for producing said compositions from various plant sources, together with various products, compounds, compositions, medical uses and methods based thereon.
• Methyl 2-azido-3-O-benzyl-2-deoxy-α-D-mamnofuranoside as a divergent intermediate for the synthesis of polyhydroxylated piperidines and pyrrolidines: synthesis of 2,5-dideoxy-2,5-imino-D-mannitol [2R,5R-dihydroxymethyl-3R,4R-dihydroxypyrrolidine]
  作者：George W.J. Fleet、Paul W. Smith

  DOI：10.1016/s0040-4020(01)90034-1

  日期：1987.1