5-氨基-6-氯喹啉 | 341010-40-0

• 物质功能分类: 医药中间体 - 喹啉类化合物
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 中文名称: 5-氨基-6-氯喹啉
• 英文名称: 6-chloro-quinolin-5-ylamine
• 英文别名: 6-chloro-[5]quinolylamine；6-Chlor-[5]chinolylamin；5-Amino-6-chlorchinolin；5-Amino-6-chloroquinoline；6-chloroquinolin-5-amine
• CAS: 341010-40-0
• 化学式: C₉H₇ClN₂
• mdl: MFCD02947117
• 分子量: 178.621
• InChiKey: MKJUMRMBGSXZBU-UHFFFAOYSA-N

物化性质

• 沸点：
  331.1±27.0 °C(Predicted)
• 密度：
  1.363±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  38.9
• 氢给体数：
  1
• 氢受体数：
  2

安全信息

• 海关编码：
  2933499090
• 危险性防范说明：
  P261,P305+P351+P338
• 危险性描述：
  H302,H315,H319,H335

SDS

Material Safety Data Sheet

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Section 1. Identification of the substance
Product Name: 5-Amino-6-chloroquinoline
Synonyms: 6-Chloroquinolin-5-amine

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Section 2. Hazards identification
Harmful by inhalation, in contact with skin, and if swallowed.

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Section 3. Composition/information on ingredients.
Ingredient name: 5-Amino-6-chloroquinoline
CAS number: 341010-40-0

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Section 4. First aid measures
Skin contact: Immediately wash skin with copious amounts of water for at least 15 minutes while removing
contaminated clothing and shoes. If irritation persists, seek medical attention.
Eye contact: Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate
flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical
attention.
Inhalation: Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.
Ingestion: Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.

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Section 5. Fire fighting measures
In the event of a fire involving this material, alone or in combination with other materials, use dry
powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus
should be worn.

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Section 6. Accidental release measures
Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national
standards.
Respiratory precaution: Wear approved mask/respirator
Hand precaution: Wear suitable gloves/gauntlets
Skin protection: Wear suitable protective clothing
Eye protection: Wear suitable eye protection
Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container
for disposal. See section 12.
Environmental precautions: Do not allow material to enter drains or water courses.

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Section 7. Handling and storage
Handling: This product should be handled only by, or under the close supervision of, those properly qualified
in the handling and use of potentially hazardous chemicals, who should take into account the fire,
health and chemical hazard data given on this sheet.
Store in closed vessels.
Storage:

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Section 8. Exposure Controls / Personal protection
Engineering Controls: Use only in a chemical fume hood.
Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.

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Section 9. Physical and chemical properties
Appearance: Not specified
Boiling point: No data
No data
Melting point:
Flash point: No data
Density: No data
Molecular formula: C9H7ClN2
Molecular weight: 178.6

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Section 10. Stability and reactivity
Conditions to avoid: Heat, flames and sparks.
Materials to avoid: Oxidizing agents.
Possible hazardous combustion products: Carbon monoxide, nitrogen oxides, hydrogen chloride.

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Section 11. Toxicological information
No data.

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Section 12. Ecological information
No data.

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Section 13. Disposal consideration
Arrange disposal as special waste, by licensed disposal company, in consultation with local waste
disposal authority, in accordance with national and regional regulations.

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Section 14. Transportation information
Non-harzardous for air and ground transportation.

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Section 15. Regulatory information
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
302, or have known CAS numbers that exceed the threshold reporting levels established by SARA
Title III, Section 313.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为反应物：
  描述：

  5-氨基-6-氯喹啉 在 硫酸 作用下， 生成 6-氯-5-喹啉醇
  参考文献：
  名称：

  Claus; Schedler, Journal fur praktische Chemie (Leipzig 1954), 1894, vol. <2> 49, p. 365

  摘要：

  DOI：
• 作为产物：
  描述：

  6-氯喹啉 在 磷化氢 、 硫酸 、 水 、 碘 、 硝酸 作用下， 生成 5-氨基-6-氯喹啉
  参考文献：
  名称：

  Claus; Schedler, Journal fur praktische Chemie (Leipzig 1954), 1894, vol. <2> 49, p. 365

  摘要：

  DOI：

文献信息

• Efficient and recyclable bimetallic Co–Cu catalysts for selective hydrogenation of halogenated nitroarenes
  作者：Yao Sheng、Baoqin Wu、Jiaan Ren、Xueguang Wang、Xiujing Zou、Xionggang Lu

  DOI：10.1016/j.jallcom.2021.163143

  日期：2022.3

  performance of the Co1Cux@CN/SiO2 catalysts were investigated for selective hydrogenation of p-chloronitrobenzene to p-chloroaniline. The Co1Cu0.30@CN/SiO2 with Cu/Co molar ratio of 0.30:1 presented much higher activity and stability than the monometallic Co@CN/SiO2 catalyst. The addition of Cu into Co1Cux@CN/SiO2 catalysts had favorable effects on the formation of highly active Co–N sites and N-doped

  通过一步浸渍 Co(NO 3 ) 2 ·6H 2 O、Cu(NO 3 ) 2 ·制备二氧化硅负载的 N 掺杂碳层，包覆 Co-Cu 纳米颗粒 (Co 1 Cu x @CN/SiO 2 ) 3H 2 O、尿素和葡萄糖，在原位碳热还原之后。研究了Cu含量对Co 1 Cu x @CN/SiO 2催化剂催化对氯硝基苯选择性加氢制备对氯苯胺的催化性能的影响。Co 1 Cu 0.30 @CN/SiO2 0.30的Cu / Co的摩尔比：1中呈现高得多的活性和稳定性比单金属钴@ CN /二氧化硅2催化剂。在 Co 1 Cu x @CN/SiO 2催化剂中加入 Cu对高活性 Co-N 位点和 N 掺杂碳层的形成有有利的影响。N掺杂碳层的作用是保护Co免受空气氧化，Co 1 Cu 0.30 @CN/SiO 2可以重复使用至少 12 个循环而不会降低催化效率。机理和原位红外研究表明，Co 和 Cu 原子之间的相互作用使
• Novel adamantane derivatives
  申请人：Ford Rhonan

  公开号：US20050090524A1

  公开（公告）日：2005-04-28

  The invention provides compounds of formula, in which m, A, R?1 and Ar have the meanings defined in the specification; processes for their preparation; pharmaceutical compositions containing them; a process for preparing the pharmaceutical compositions; and their use in therapy.

  本发明提供了式子中的化合物，其中m，A，R?1和Ar在说明书中定义了它们的含义；用于制备它们的过程；包含它们的制药组合物；制备制药组合物的过程；以及它们在治疗中的应用。
• Novel Adamantane Derivatives
  申请人：Ford Rhonan

  公开号：US20090018133A1

  公开（公告）日：2009-01-15

  The invention provides compounds of formula (I), in which m, A, R 1 and Ar have the meanings defined in the specification; processes for their preparation; pharmaceutical compositions containing them; a process for preparing the pharmaceutical compositions; and their use in therapy.

  本发明提供公式（I）的化合物，其中m，A，R1和Ar的含义在规范中定义；它们的制备过程；含有它们的药物组合物；制备药物组合物的过程；以及它们在治疗中的使用。
• Senda, Yakugaku Zasshi/Journal of the Pharmaceutical Society of Japan, 1952, vol. 72, p. 296,298
  作者：Senda

  DOI：——

  日期：——
• ISIKAVA, XIROSI;TAFUSA, FUDZIO;NAKAGAVA, KADZUYUKI
  作者：ISIKAVA, XIROSI、TAFUSA, FUDZIO、NAKAGAVA, KADZUYUKI

  DOI：——

  日期：——