(2R,4S)-N-苄基-2-t-丁基恶唑烷-4-羧酸,甲酯 | 145451-89-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: (2R,4S)-N-苄基-2-t-丁基恶唑烷-4-羧酸,甲酯
• 英文名称: (2R,4S)-N-Benzyl-2-t-butyloxazolidine-4-carboxylic Acid, Methyl Ester
• 英文别名: methyl (2R,4S)-3-benzyl-2-tert-butyl-1,3-oxazolidine-4-carboxylate
• CAS: 145451-89-4
• 化学式: C₁₆H₂₃NO₃
• 分子量: 277.364
• InChiKey: ZTAOHROUZKWTRP-DZGCQCFKSA-N

物化性质

• 溶解度：
  可溶于丙酮、二氯甲烷、乙酸乙酯、甲醇

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  20
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  38.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (2R,4S)-N-苄基-2-t-丁基恶唑烷-4-羧酸,甲酯 在 sodium tetrahydroborate 、 草酰氯 、 二甲基亚砜 、 三乙胺 、 lithium hexamethyldisilazane 作用下， 以 四氢呋喃 、 甲醇 、 二氯甲烷 为溶剂， 反应 2.0h， 生成 methyl (2R,4R)-3-benzyl-4-[(S)-[(2R,4S)-3-benzyl-2-tert-butyl-1,3-oxazolidin-4-yl]-hydroxymethyl]-2-tert-butyl-1,3-oxazolidine-4-carboxylate
  参考文献：
  名称：

  Synthetic studies toward kaitocephalin

  摘要：

  Synthetic studies toward the total synthesis of kaitocephalin 1. whose stereochemical assignment was undetermined at the time of commencement. were undertaken in an attempt to provide a general methodology to gain access to any one of all 32 possible stereoisomers. An interesting, unexpected, result was observed in the anticipated stereoselective key aldol reaction. (C) 2001 Published by Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4039(01)01631-8
• 作为产物：
  描述：

  苯甲醛 、 alkaline earth salt of/the/ methylsulfuric acid 在 对甲苯磺酸 、 三乙胺 作用下， 以 甲醇 、 甲苯 为溶剂， 反应 7.0h， 生成 (2R,4S)-N-苄基-2-t-丁基恶唑烷-4-羧酸,甲酯
  参考文献：
  名称：

  Synthetic studies toward kaitocephalin

  摘要：

  Synthetic studies toward the total synthesis of kaitocephalin 1. whose stereochemical assignment was undetermined at the time of commencement. were undertaken in an attempt to provide a general methodology to gain access to any one of all 32 possible stereoisomers. An interesting, unexpected, result was observed in the anticipated stereoselective key aldol reaction. (C) 2001 Published by Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4039(01)01631-8

文献信息

• Synthetic studies toward kaitocephalin
  作者：Teck-Peng Loh、Yew-Keong Chok、Zheng Yin

  DOI：10.1016/s0040-4039(01)01631-8

  日期：2001.10

  Synthetic studies toward the total synthesis of kaitocephalin 1. whose stereochemical assignment was undetermined at the time of commencement. were undertaken in an attempt to provide a general methodology to gain access to any one of all 32 possible stereoisomers. An interesting, unexpected, result was observed in the anticipated stereoselective key aldol reaction. (C) 2001 Published by Elsevier Science Ltd.