methyl (2R,4R)-3-benzyl-4-[(S)-[(2R,4S)-3-benzyl-2-tert-butyl-1,3-oxazolidin-4-yl]-hydroxymethyl]-2-tert-butyl-1,3-oxazolidine-4-carboxylate | 1055035-23-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: methyl (2R,4R)-3-benzyl-4-[(S)-[(2R,4S)-3-benzyl-2-tert-butyl-1,3-oxazolidin-4-yl]-hydroxymethyl]-2-tert-butyl-1,3-oxazolidine-4-carboxylate
• CAS: 1055035-23-8
• 化学式: C₃₁H₄₄N₂O₅
• 分子量: 524.701
• InChiKey: BJWWGIFCTGXKSJ-JJFDYANOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  38
• 可旋转键数：
  10
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.58
• 拓扑面积：
  71.5
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  二甲基亚砜 、 methyl (2R,4R)-3-benzyl-4-[(S)-[(2R,4S)-3-benzyl-2-tert-butyl-1,3-oxazolidin-4-yl]-hydroxymethyl]-2-tert-butyl-1,3-oxazolidine-4-carboxylate 在 乙酸酐 、 溶剂黄146 作用下， 生成 (2R,4R)-3-Benzyl-4-((2R,4S)-3-benzyl-2-tert-butyl-oxazolidine-4-carbonyl)-2-tert-butyl-oxazolidine-4-carboxylic acid methyl ester 、
  参考文献：
  名称：

  Synthetic studies toward kaitocephalin

  摘要：

  Synthetic studies toward the total synthesis of kaitocephalin 1. whose stereochemical assignment was undetermined at the time of commencement. were undertaken in an attempt to provide a general methodology to gain access to any one of all 32 possible stereoisomers. An interesting, unexpected, result was observed in the anticipated stereoselective key aldol reaction. (C) 2001 Published by Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4039(01)01631-8
• 作为产物：
  描述：

  L-N-苄基丝氨酸甲酯 在 对甲苯磺酸 、 lithium hexamethyldisilazane 作用下， 以 甲苯 为溶剂， 反应 6.0h， 生成 methyl (2R,4R)-3-benzyl-4-[(S)-[(2R,4S)-3-benzyl-2-tert-butyl-1,3-oxazolidin-4-yl]-hydroxymethyl]-2-tert-butyl-1,3-oxazolidine-4-carboxylate
  参考文献：
  名称：

  Synthetic studies toward kaitocephalin

  摘要：

  Synthetic studies toward the total synthesis of kaitocephalin 1. whose stereochemical assignment was undetermined at the time of commencement. were undertaken in an attempt to provide a general methodology to gain access to any one of all 32 possible stereoisomers. An interesting, unexpected, result was observed in the anticipated stereoselective key aldol reaction. (C) 2001 Published by Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4039(01)01631-8