(6R,7S)-6-(4-Methoxy-benzyloxy)-2,6,7-trimethyl-9-methylene-pentadec-2-en-8-ol | 224580-08-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: (6R,7S)-6-(4-Methoxy-benzyloxy)-2,6,7-trimethyl-9-methylene-pentadec-2-en-8-ol
• 英文别名: (6R,7S)-6-[(4-methoxyphenyl)methoxy]-2,6,7-trimethyl-9-methylidenepentadec-2-en-8-ol
• CAS: 224580-08-9
• 化学式: C₂₇H₄₄O₃
• 分子量: 416.645
• InChiKey: IANOPLPOTNWALV-IAEHUISDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.1
• 重原子数：
  30
• 可旋转键数：
  15
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.63
• 拓扑面积：
  38.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (6R,7S)-6-(4-Methoxy-benzyloxy)-2,6,7-trimethyl-9-methylene-pentadec-2-en-8-ol 在 palladium diacetate 、 三乙胺 、 三苯基膦 、 calcium carbonate 作用下， 以 二氯甲烷 、 甲苯 为溶剂， 反应 6.0h， 生成 1-methoxy-4-[[(6R,7E)-2,6,7-trimethyl-9-methylidenepentadeca-2,7-dien-6-yl]oxymethyl]benzene
  参考文献：
  名称：

  2. Synthesis of the C.14–C.26 hydrophilic domain of amphidinolide B1 and formation of the (E)-1,1′,3-trisubstituted diene sector

  摘要：

  In the preceding letter, we described a synthesis of the conserved C.1-C.13 hydrophobic domain common to the potent B-type amphidinolides. In this letter, we present syntheses of the C.14-C.26 hydrophilic domain specific to amphidinolide B1 and a model for uniting the hydrophobic and hydrophilic domains to form the (E)-1,1',3-trisubstituted diene. (C) 1999 Published by Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(99)00207-5
• 作为产物：
  描述：

  (2R,3R)-3-methyl-3-(4-methyl-3-pentenyl)oxiranemethanol 在 N-甲基吲哚酮 、 四丙基高钌酸铵 、 camphor-10-sulfonic acid 、 叔丁基锂 、 二异丁基氢化铝 作用下， 以 乙醚 、 二氯甲烷 为溶剂， 生成 (6R,7S)-6-(4-Methoxy-benzyloxy)-2,6,7-trimethyl-9-methylene-pentadec-2-en-8-ol
  参考文献：
  名称：

  2. Synthesis of the C.14–C.26 hydrophilic domain of amphidinolide B1 and formation of the (E)-1,1′,3-trisubstituted diene sector

  摘要：

  In the preceding letter, we described a synthesis of the conserved C.1-C.13 hydrophobic domain common to the potent B-type amphidinolides. In this letter, we present syntheses of the C.14-C.26 hydrophilic domain specific to amphidinolide B1 and a model for uniting the hydrophobic and hydrophilic domains to form the (E)-1,1',3-trisubstituted diene. (C) 1999 Published by Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(99)00207-5

文献信息

• 2. Synthesis of the C.14–C.26 hydrophilic domain of amphidinolide B1 and formation of the (E)-1,1′,3-trisubstituted diene sector
  作者：Hugo M. Eng、David C. Myles

  DOI：10.1016/s0040-4039(99)00207-5

  日期：1999.3

  In the preceding letter, we described a synthesis of the conserved C.1-C.13 hydrophobic domain common to the potent B-type amphidinolides. In this letter, we present syntheses of the C.14-C.26 hydrophilic domain specific to amphidinolide B1 and a model for uniting the hydrophobic and hydrophilic domains to form the (E)-1,1',3-trisubstituted diene. (C) 1999 Published by Elsevier Science Ltd. All rights reserved.