Methyl-tomentosolat-acetat | 14021-21-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: Methyl-tomentosolat-acetat
• 英文别名: methyl tomentosolate acetate；3β-acetoxy-ursadien-(12.19)-oic acid-(28)-methyl ester；3β-Acetoxy-ursadien-(12.19)-saeure-(28)-methylester；O-Acetyl-tomentosolsaeure-methylester；Acetyl sanguisorbigenin methyl ester；Tomentosolsaeure-methylester-acetat
• CAS: 14021-21-7
• 化学式: C₃₃H₅₀O₄
• 分子量: 510.758
• InChiKey: NDWGFBQLMAEBJK-AVXXZDAZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.81
• 重原子数：
  37.0
• 可旋转键数：
  2.0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.82
• 拓扑面积：
  52.6
• 氢给体数：
  0.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  Methyl-tomentosolat-acetat 生成 19β,20-Dihydroxy-uvaol
  参考文献：
  名称：

  Brieskorn,C.H.; Wunderer,H., Chemische Berichte, 1967, vol. 100, p. 1252 - 1265

  摘要：

  DOI：
• 作为产物：
  描述：

  methyl 3β-acetyl-19α-hydroxyurs-Δ¹²-ene-28-oate 在 高氯酸 、 乙酸酐 作用下， 生成 Methyl-tomentosolat-acetat
  参考文献：
  名称：

  Brieskorn,C.H.; Wunderer,H., Chemische Berichte, 1967, vol. 100, p. 1252 - 1265

  摘要：

  DOI：

文献信息

• Effect of Ramipril on Endothelial Dysfunction in Patients with Essential Hypertension
  作者：Li Fang、Fang Zheng、Tian Qingyin、Zhong Ming、Hu Yanyan

  DOI：10.2165/00044011-200222070-00005

  日期：——

  To evaluate the effect of ramipril, an ACE inhibitor, on flow-mediated dilation (FMD) of the brachial artery (an index of endothelium-dependent vasodilation), in patients with hypertension. The study population included 96 Chinese patients with newly diagnosed essential hypertension (52 men and 44 women; mean age 56 ± 7 years) and 30 normotensive subjects (16 men and 14 women; mean age 53± 9 years). The 96 patients with essential hypertension were randomised to receive 3 months of oral ramipril 5mg once daily (ramipril group, 49 cases) or oral nitrendipine 10mg twice daily (nitrendipine group, 47 cases). Baseline diameter, reactive hyperaemia (RH), FMD and nitroglycerin-induced dilation (NTG dilation) were evaluated with the non-invasive ultrasound method before and after treatment in the two hypertensive groups. FMD was significantly lower in the two hypertensive groups than in the control group before treatment and improved significantly in the ramipril group after treatment compared with before treatment (5.1± 2.2 versus 1.8 ± 1.2, p < 0.01). The baseline diameters of the brachial arteries, RH and NTG dilation showed no difference between the control group and the two hypertensive groups before treatment and remained unchanged after treatment in both the ramipril group and the nitrendipine group. Blood pressure was reduced to the same extent in the two hypertensive groups (p > 0.05) and the changes in mean blood pressure did not correlate with the changes in FMD in the ramipril group (r = 0.22). In addition to blood pressure control, ramipril can improve endothelial dysfunction in patients with essential hypertension.

  评价雷米普利（一种血管紧张素转换酶抑制剂）对高血压患者肱动脉血流介导扩张（FMD，内皮依赖性血管扩张的指标）的影响。研究人群包括96名新诊断的原发性高血压的中国患者（52名男性和44名女性；平均年龄56±7岁）和30名血压正常者（16名男性和14名女性；平均年龄53±9岁）。96名原发性高血压患者被随机分配接受3个月的口服雷米普利5mg每日一次（雷米普利组，49例）或口服尼群地平10mg每日两次（尼群地平组，47例）。使用无创超声方法在治疗前后评估两个高血压组的基线直径、反应性充血（RH）、FMD和硝酸甘油诱导的扩张（NTG扩张）。两个高血压组的FMD在治疗前明显低于对照组，在治疗后雷米普利组明显改善（5.1±2.2对1.8±1.2，p < 0.01）。肱动脉的基线直径、RH和NTG扩张在治疗前对照组和两个高血压组之间无差异，治疗后雷米普利组和尼群地平组保持不变。两组高血压患者的血压降低程度相同（p > 0.05），平均血压的变化与雷米普利组FMD的变化无相关性（r = 0.22）。除了控制血压外，雷米普利还可以改善原发性高血压患者的内皮功能障碍。
• Two triterpenoid glycosides from leaves of Ilex cornuta
  作者：Tsutomu Nakanishi、Hiroko Terai、Masao Nasu、Iwao Miura、Kaisuke Yoneda

  DOI：10.1016/0031-9422(82)80145-3

  日期：1982.1

  Abstract Two new triterpene glycosides, a diglycoside (as the corresponding methyl ester) and a bis-desmoside were isolated from leaves of Ilex cornuta . The

  摘要 从冬青叶中分离得到两种新的三萜糖苷，一种是二糖苷（作为相应的甲酯）和一种双糖苷。这
• Triterpenoids in apple peel
  作者：W. Lawrie、J. McLean、M. El-Garby Younes

  DOI：10.1039/j39670000851

  日期：——

  Apple peel, a common source of ursolic acid, is shown to contain, in addition, two new triterpenoid acids of the ursane series which have been identified as 20β-hydroxyursolic acid and 2ζ,20β-dihydroxyursonic acid.

  苹果皮是熊果酸的常见来源，另外还显示了熊果系列的两种新的三萜酸，它们已被鉴定为20β-羟基熊果酸和2ζ，20β-二羟基熊果酸。