(3R,3aS,7R,8aS)-3,8,8-trimethyl-2,3,4,7,8,8a-hexahydro-1H-3a,7-cedarane-6-carboxylic acid methyl ester | 24394-07-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: (3R,3aS,7R,8aS)-3,8,8-trimethyl-2,3,4,7,8,8a-hexahydro-1H-3a,7-cedarane-6-carboxylic acid methyl ester
• 英文别名: (8aS)-3c.8.8-trimethyl-(8arH)-1.2.4.7.8.8a-hexahydro-3H-3at.7t-methano-azulene-carboxylic acid-(6)-methyl ester；(8aS)-3c.8.8-Trimethyl-(8arH)-1.2.4.7.8.8a-hexahydro-3H-3at.7t-methano-azulen-carbonsaeure-(6)-methylester；Cedren-3-12-saeuremethylester
• CAS: 24394-07-8
• 化学式: C₁₆H₂₄O₂
• 分子量: 248.365
• InChiKey: ZCNSDKWZZLYWQR-LESCFKLSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.57
• 重原子数：
  18.0
• 可旋转键数：
  1.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.81
• 拓扑面积：
  26.3
• 氢给体数：
  0.0
• 氢受体数：
  2.0

反应信息

• 作为反应物：
  描述：

  (3R,3aS,7R,8aS)-3,8,8-trimethyl-2,3,4,7,8,8a-hexahydro-1H-3a,7-cedarane-6-carboxylic acid methyl ester 在 sodium dichromate 、 溶剂黄146 作用下， 以 苯 为溶剂， 生成 5-Keto-cedren-3-12-saeure-methylester
  参考文献：
  名称：

  lac树脂的化学-II lac酸（第2部分）：Laccijalaric酸

  摘要：

  描述了一种新的伯乳香酸（lacojalaric干旱）的分离和结构解析，这种新的伯乳香酸属于倍半萜的雪松烯类。该酸与（-）-α-雪松烯的直接化学相关性也已经实现。

  DOI：

  10.1016/s0040-4020(01)82917-3
• 作为产物：
  描述：

  [3R-(3alpha,3abeta,7beta,8aalpha)]-2,3,4,7,8,8alpha-六氢-3,8,8-三甲基-1H-3a,7-甲桥薁-6-甲醛 在 chromium(VI) oxide 、 硫酸 作用下， 以 丙酮 为溶剂， 生成 (3R,3aS,7R,8aS)-3,8,8-trimethyl-2,3,4,7,8,8a-hexahydro-1H-3a,7-cedarane-6-carboxylic acid methyl ester
  参考文献：
  名称：

  lac树脂的化学-II lac酸（第2部分）：Laccijalaric酸

  摘要：

  描述了一种新的伯乳香酸（lacojalaric干旱）的分离和结构解析，这种新的伯乳香酸属于倍半萜的雪松烯类。该酸与（-）-α-雪松烯的直接化学相关性也已经实现。

  DOI：

  10.1016/s0040-4020(01)82917-3

文献信息

• 柏木醇衍生物、其制备方法及其应用
  申请人：中南民族大学

  公开号：CN112592252B

  公开（公告）日：2022-05-13

  本发明涉及合成药物技术领域，具体而言，涉及柏木醇衍生物、其制备方法及其应用。柏木醇衍生物为以下结构式所示化合物中的任意一种、其互变异构体、水合物、溶剂化物或其药学上可接受的盐，以及柏木醇衍生物对病毒、特别是流感病毒有良好的治疗作用，继而扩大了柏木醇及其衍生物的应用范围，且扩大了柏木醇类衍生物的种类。
• Presence of bovine leptin in edible commercial milk and infant formula
  作者：M. Lage、R. Baldelli、J. P. Camiña、J. Rodriguez-Garcia、A. Peñalva、C. Dieguez、F. F. Casanueva

  DOI：10.1007/bf03345099

  日期：2002.9

  Leptin is a hormone secreted by the adipocytes that contribute to the control of energy balance, and circulating leptin levels reflect the amount of adipose tissue in the body, helping to regulate food intake and energy expenditure. Since it has been shown that human milk contains immunoreactive leptin, which is identical to intact human leptin, we decided to investigate the possible presence of immunoreactive bovine leptin in different kinds of common commercial milk. To determine the presence or absence of immunoreactive leptin in bovine milk for human consumption, 81 samples (66 commercial pasteurized milk and 15 artificial formulae for new-born babies) of the most common Spanish commercial types of milk were studied. All samples were evaluated before and after centrifugation, and leptin levels were measured by RIA. Leptin was detected in all sampies and RIA standard curves were not perturbed when centrifuged and non-centrifuged milk replaced the buffer. Mean values of leptin in full-cream, semi-skimmed and skimmed samples, were: 5.7+/-0.3 ng/ml, 4.1+/-0.1 ng/ml, 3.7+/-0.1 ng/ml (significantly different). Leptin values were reduced after centrifugation. A significant correlation was observed between leptin levels and lipid content (p<0.0005, r=0.67) while no correlation was observed with respect to carbohydrate and protein levels. Interestingly, some preparations of infant formulae present very high leptin values reaching up to 18.9 ng/ml. In conclusion, leptin is present in significant and variable concentrations in edible commercial bovine milk, with higher concentrations in infant formula.