6-硝基喹啉-2-胺 | 49609-07-6

• 物质功能分类: 医药中间体 - 喹啉类化合物
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 中文名称: 6-硝基喹啉-2-胺
• 英文名称: 2-amino-6-nitroquinoline
• 英文别名: 6-nitroquinolin-2-amine；6-nitro-[2]quinolylamine；6-Nitro-[2]chinolylamin
• CAS: 49609-07-6
• 化学式: C₉H₇N₃O₂
• mdl: MFCD08690766
• 分子量: 189.173
• InChiKey: IBWOBEUJEJNYOA-UHFFFAOYSA-N

物化性质

• 熔点：
  261 °C
• 沸点：
  403.9±25.0 °C(Predicted)
• 密度：
  1.445±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  14
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  84.7
• 氢给体数：
  1
• 氢受体数：
  4

安全信息

• 海关编码：
  2933499090

反应信息

• 作为反应物：
  描述：

  6-硝基喹啉-2-胺 在 三氯化铁 、 肼 作用下， 以 甲醇 为溶剂， 生成 quinoline-2,6-diyldiamine
  参考文献：
  名称：

  2-Aminoquinoline melanin-concentrating hormone (MCH)1R antagonists

  摘要：

  A series of 2-aminoquinoline compounds was prepared and evaluated in MCH1R binding and functional antagonist assays. Small dialkyl, methylalkyl, methylcycloalkyl, and cyclic amines were tolerated at the quinoline 2-position. The in vivo efficacy of compound 12 was explored and compared to that of a related inactive analog to determine their effects on food intake and body weight in rodents. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2006.08.006
• 作为产物：
  描述：

  6-nitroquinoline-N-oxide 在 氢氧化钾 、 三氯氧磷 作用下， 生成 6-硝基喹啉-2-胺
  参考文献：
  名称：

  349. 4-氯-和6-硝基-喹啉的衍生物

  摘要：

  DOI：

  10.1039/jr9480001707

文献信息

• Factor IXa inhibitors
  申请人：Boyle Craig

  公开号：US09161924B2

  公开（公告）日：2015-10-20

  The present invention provides a compound of Formula (I) as described herein, or a pharmaceutically acceptable salt thereof. The present invention also provides pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing a thromboses, embolisms, hypercoagulability or fibrotic changes.

  本发明提供了一种公式（I）所描述的化合物，或其药学上可接受的盐。本发明还提供了包含一种或多种上述化合物的药物组合物，并且提供了使用该化合物用于治疗或预防血栓形成、栓塞、高凝状态或纤维化变化的方法。
• 2-Aminoquinoline compounds
  申请人：DeVita J. Robert

  公开号：US20050026915A1

  公开（公告）日：2005-02-03

  The present invention is concerned with compounds of the general Formula I: and pharmaceutically acceptable salts thereof, which are useful as melanin concentrating hormone receptor antagonists, particularly MCH-1R antagonists. As such, compounds of the present invention are useful for the treatment or prevention of obesity or eating disorders associated with excessive food intake and complications thereof, osteoarthritis, certain cancers, AIDS wasting, cachexia, frailty (particularly in elderly), mental disorders stress, cognitive disorders, sexual function, reproductive function, kidney function, locomotor disorders, attention deficit disorder (ADD), substance abuse disorders and dyskinesias, Huntington's disease, epilepsy, memory function, and spinal muscular atrophy. Compounds of formula I may therefore be used in the treatment of these conditions, and in the manufacture of a medicament useful in treating these conditions. Pharmaceutical formulations comprising one of the compounds of formula (I) as an active ingredient are disclosed, as are processes for preparing these compounds.

  本发明涉及一般式I的化合物及其药学上可接受的盐，其作为黑色素浓集激素受体拮抗剂，特别是MCH-1R拮抗剂而有用。因此，本发明的化合物可用于治疗或预防与过度食物摄入及其并发症有关的肥胖症或进食障碍，骨关节炎，某些癌症，艾滋病消耗症，消瘦，衰弱（尤其是老年人），精神障碍，压力，认知障碍，性功能，生殖功能，肾功能，运动障碍，注意力缺陷障碍（ADD），物质滥用障碍和运动障碍，亨廷顿病，癫痫，记忆功能和脊髓肌萎缩。因此，式I的化合物可用于治疗这些疾病，并用于制造用于治疗这些疾病的药物。本发明还公开了包含式（I）中的一种化合物作为活性成分的制药配方，以及制备这些化合物的过程。
• MORPHOLINONE COMPOUNDS AS FACTOR IXA INHIBITORS
  申请人：CHACKALAMANNIL Samuel

  公开号：US20110135650A1

  公开（公告）日：2011-06-09

  The present invention provides a compound of Formula (I) as described herein, or a pharmaceutically acceptable salt or a solvate thereof. The present invention also provides pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing a thromboses, embolisms, hypercoagulability or fibrotic changes.

  本发明提供了公式（I）所述的化合物，或其药学上可接受的盐或溶剂。本发明还提供了包含一种或多种所述化合物的药物组合物，并且提供了使用所述化合物治疗或预防血栓形成，栓塞，高凝状态或纤维化变化的方法。
• FACTOR IXA INHIBITORS
  申请人：Boyle Craig

  公开号：US20140219989A1

  公开（公告）日：2014-08-07

  The present invention provides a compound of Formula (I) as described herein, or a pharmaceutically acceptable salt thereof. The present invention also provides pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing a thromboses, embolisms, hypercoagulability or fibrotic changes.

  本发明提供了公式（I）所述的化合物或其药学上可接受的盐。本发明还提供包含一种或多种所述化合物的制药组合物，以及使用所述化合物治疗或预防血栓、栓塞、高凝状态或纤维化变化的方法。
• DE591480
  申请人：——

  公开号：——

  公开（公告）日：——