6-(tert-butyl)-8-methyl-4-[(methylthio)methyl]azulene-1-carbaldehyde | 253778-36-8

• 分子结构分类: 有机化合物 - 碳氢化合物 - 不饱和烃
• 英文名称: 6-(tert-butyl)-8-methyl-4-[(methylthio)methyl]azulene-1-carbaldehyde
• 英文别名: 6-Tert-butyl-8-methyl-4-(methylsulfanylmethyl)azulene-1-carbaldehyde
• CAS: 253778-36-8
• 化学式: C₁₈H₂₂OS
• 分子量: 286.438
• InChiKey: SOAROBBZMUZJCM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  42.4
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  6-(tert-butyl)-8-methyl-4-[(methylthio)methyl]azulene-1-carbaldehyde 在 chromium dichloride 、 palladium diacetate 、 sodium tetrahydroborate 、 N-氯代丁二酰亚胺 、 三氟化硼乙醚 、 silver carbonate 、 三氟乙酸 、 mercury(II) oxide 作用下， 以 四氢呋喃 、 四氯化碳 、 二氯甲烷 、 水 、 N,N-二甲基甲酰胺 、 甲苯 为溶剂， 反应 45.0h， 生成 dimethyl 8-(tert-butyl)-1,10-dimethyl-6-[(E,E)-4-phenylbuta-1,3-dienyl]heptalene-4,5-dicarboxylate
  参考文献：
  名称：

  Synthesis of 6-Styrylheptalenes

  摘要：

  4-Methylazulenes 3, 15, and 23 were transformed into 4-[(methylthio)methyl]azulene 4, and azulene-4-carbaldehyde dimethyl dithioacetals 16 and 24, respectively. Vilsmeier formylation of 4 and 16, and subsequent reduction led to the I-methyl derivatives 6 and 18, respectively. The thermal reaction of azulenes 6, 18, and 24 with dimethyl acetylenedicarboxylate (ADM) in toluene afforded heptalenes with a (methylthio)methyl group or a [bis(methylthio)]methyl group at C(6). Chlorination of [(methylthio)methyl]heptalene 7, followed by treatment with HgO and BF3. OEt2 in aqueous tetrahydrofuran (THF), led to 6-formylheptalene-dicarboxylate 12 in excellent yield. Similarly. hydrolysis of 18 and 24 by HgO and BF3. OEt2 in aqueous THF afforded the 6-formyl derivatives 21 and 27, respectively. Wittig reaction of the 6-formyl-substituted heptalenes and phosphonium salts 13a-e in the two-phase system CH2CI2/2N aqueous NaOH resulted in the formation of 6-styryl-substituted heptalenes.

  DOI：

  10.1002/(sici)1522-2675(19991006)82:10<1690::aid-hlca1690>3.0.co;2-d
• 作为产物：
  描述：

  6-(tert-butyl)-4,8-dimethylazulene 在 正丁基锂 、 二异丙胺 、 三氯氧磷 作用下， 以 四氢呋喃 为溶剂， 反应 4.0h， 生成 6-(tert-butyl)-8-methyl-4-[(methylthio)methyl]azulene-1-carbaldehyde
  参考文献：
  名称：

  Synthesis of 6-Styrylheptalenes

  摘要：

  4-Methylazulenes 3, 15, and 23 were transformed into 4-[(methylthio)methyl]azulene 4, and azulene-4-carbaldehyde dimethyl dithioacetals 16 and 24, respectively. Vilsmeier formylation of 4 and 16, and subsequent reduction led to the I-methyl derivatives 6 and 18, respectively. The thermal reaction of azulenes 6, 18, and 24 with dimethyl acetylenedicarboxylate (ADM) in toluene afforded heptalenes with a (methylthio)methyl group or a [bis(methylthio)]methyl group at C(6). Chlorination of [(methylthio)methyl]heptalene 7, followed by treatment with HgO and BF3. OEt2 in aqueous tetrahydrofuran (THF), led to 6-formylheptalene-dicarboxylate 12 in excellent yield. Similarly. hydrolysis of 18 and 24 by HgO and BF3. OEt2 in aqueous THF afforded the 6-formyl derivatives 21 and 27, respectively. Wittig reaction of the 6-formyl-substituted heptalenes and phosphonium salts 13a-e in the two-phase system CH2CI2/2N aqueous NaOH resulted in the formation of 6-styryl-substituted heptalenes.

  DOI：

  10.1002/(sici)1522-2675(19991006)82:10<1690::aid-hlca1690>3.0.co;2-d

文献信息

• Synthesis of 6-Styrylheptalenes
  作者：Jianfeng Song、Hans-Jürgen Hansen

  DOI：10.1002/(sici)1522-2675(19991006)82:10<1690::aid-hlca1690>3.0.co;2-d

  日期：1999.10.6

  4-Methylazulenes 3, 15, and 23 were transformed into 4-[(methylthio)methyl]azulene 4, and azulene-4-carbaldehyde dimethyl dithioacetals 16 and 24, respectively. Vilsmeier formylation of 4 and 16, and subsequent reduction led to the I-methyl derivatives 6 and 18, respectively. The thermal reaction of azulenes 6, 18, and 24 with dimethyl acetylenedicarboxylate (ADM) in toluene afforded heptalenes with a (methylthio)methyl group or a [bis(methylthio)]methyl group at C(6). Chlorination of [(methylthio)methyl]heptalene 7, followed by treatment with HgO and BF3. OEt2 in aqueous tetrahydrofuran (THF), led to 6-formylheptalene-dicarboxylate 12 in excellent yield. Similarly. hydrolysis of 18 and 24 by HgO and BF3. OEt2 in aqueous THF afforded the 6-formyl derivatives 21 and 27, respectively. Wittig reaction of the 6-formyl-substituted heptalenes and phosphonium salts 13a-e in the two-phase system CH2CI2/2N aqueous NaOH resulted in the formation of 6-styryl-substituted heptalenes.