N-乙基-N-氯乙基间甲苯胺 | 22564-43-8

• 物质功能分类: 有机原料 - 氨基化合物
• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: N-乙基-N-氯乙基间甲苯胺
• 中文别名: N-乙基-N-氯乙基-3-甲基苯胺
• 英文名称: N-(2-chloro-ethyl)-N-ethyl-3-methyl-aniline
• 英文别名: N-ethyl-N-(2-chloro-ethyl)-m-toluidine；N-Aethyl-N-(2-chlor-aethyl)-m-toluidin；N-(2-chloroethyl)-N-ethylaniline；N-ethyl-N-(β-chloroethyl)-m-toluidine；N-ethyl-N-β-chloroethyl-3-toluidine；N-2-chloroethyl-N-ethyl-m-toluidine；N-(2-chloroethyl)-N-ethyl-3-methylaniline
• CAS: 22564-43-8
• 化学式: C₁₁H₁₆ClN
• 分子量: 197.708
• InChiKey: DLRPOOIAFCOLII-UHFFFAOYSA-N

物化性质

• 沸点：
  143-144 °C(Press: 13-14 Torr)
• 密度：
  1.051±0.06 g/cm3(Predicted)
• LogP：
  3.95

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

安全信息

• 海关编码：
  2921430090

制备方法与用途

用途：用作有机合成中的中间体。

反应信息

• 作为反应物：
  描述：

  N-乙基-N-氯乙基间甲苯胺 在 氢溴酸 作用下， 生成 N-(2-氨基乙基)-N-乙基间甲苯胺
  参考文献：
  名称：

  Chemical Constitution, Electrochemical, Photographic and Allergenic Properties of p-Amino-N-dialkylanilines¹

  摘要：

  DOI：

  10.1021/ja01151a037
• 作为产物：
  描述：

  N-乙基-N-羟乙基间甲苯胺 在 三氯氧磷 作用下， 生成 N-乙基-N-氯乙基间甲苯胺
  参考文献：
  名称：

  Chemical Constitution, Electrochemical, Photographic and Allergenic Properties of p-Amino-N-dialkylanilines¹

  摘要：

  DOI：

  10.1021/ja01151a037

文献信息

• Dyeing process
  申请人：Imperial Chemical Industries Limited

  公开号：US03934972A1

  公开（公告）日：1976-01-27

  Dyeing cellulose or cellulose/polyester blends by applying unsulphonated dyestuffs containing cyclic anhydride groups, anhydride-forming dicarboxylic acid groups or half-esters or half-amides thereof, as free acids or as salts with ammonia or volatile amines, and heating the fibre until dyestuff fixation takes place.

  通过应用含有环酐基团、酐形成二羧酸基团或其半酯或半酰胺的未磺化染料，作为游离酸或与氨或挥发性胺盐形式，对纤维素或纤维素/涤纶混纺物进行染色，并加热纤维直至染料固定发生。
• Certain benzazol-2-ylthio compounds
  申请人：Ciba-Geigy AG

  公开号：US04035380A1

  公开（公告）日：1977-07-12

  Water-insoluble styryl dyestuffs of the formula ##STR1## in which X represents a cyano, carbo-lower alkoxy or phenylsulphone group, Y.sub.1 and Y.sub.2 each represents a hydrogen atom, an lower alkyl or lower alkoxy or phenoxy group, R represents a lower alkyl, phenyl-lower-alkyl, cyano-lower-alkyl, lower alkoxyalkyl or acyloxyalkyl group or a radical of the formula --A--S--B, and A represent a lower alkylene group that may be substituted by a lower alkanoyloxy or a benzoyloxy group and B represents a heterocyclic radical.

  式为##STR1##的水不溶性苯乙烯染料，其中X代表氰基、低碳基氧或苯基磺酰基，Y.sub.1和Y.sub.2各代表氢原子、低碳基或低碳基氧或苯氧基，R代表低碳基、苯基-低碳基、氰基-低碳基、低碳基氧基-低碳基或酰氧基-低碳基基团或公式--A--S--B的基团，其中A代表可能被低烷酰氧基或苯甲酰氧基取代的低碳基亚烷基，B代表杂环基团。
• Azo dyes from five membered ring heterocyclic amines and aniline,
  申请人：Eastman Kodak Company

  公开号：US04301069A1

  公开（公告）日：1981-11-17

  Disclosed are mono azo dyes derived from diazotized 5-membered heterocyclic amines and certain aniline, 1,2,3,4-tetrahydroquinoline, and benzomorpholine couplers containing thiosulfate alkyl groups. These dyes are useful for dyeing synthetic fibers, cellulose acetate and wool, and particularly impart fast violet to blue shades on polyamide fibers, and in general, exhibit improved properties such as fastness to light, sublimation, ozone, oxides of nitrogen, perspiration, crock, and wash, and exhibit excellent build, pH stability, bloom resistance, depth of shade, leveling, migration, and the like. The dyes have the general formula: D--N.dbd.N--Coupler wherein D is a thiadiazol, isothiazol, pyrazol or thiophene type radical, and the Coupler is an aniline, tetrahydroquinoline, or benzomorpholine derivative wherein a --ZSSO.sub.3 M group is attached to the nitrogen thereof, the coupler ring may contain substituents such as alkyl, alkoxy, halogen, acylamido, alkylthio or aryloxy, the remaining hydrogen of the aniline coupler may be replaced by a substituent such as alkyl, substituted alkyl, alkenyl, aryl, or cycloalkyl, M is Na.sup.+, K.sup.+, NH.sub.4.sup.+ or H.sup.+, and Z is a linking group such as ethylene.

  本发明涉及通过重氮化五元杂环胺和某些苯胺、1,2,3,4-四氢喹啉和苯基吗啡啶偶联剂制备的单偶氮染料，这些染料适用于染色合成纤维、醋酸纤维素和羊毛，特别是在聚酰胺纤维上呈现出快速紫色到蓝色的色调，并且通常具有改良的性能，如耐光、升华、臭氧、氮氧化物、汗水、脱色和洗涤的快速性，并且具有出色的建筑、pH稳定性、花期抗性、色深、平整、迁移等特点。该染料具有一般式：D-N.dbd.N-Coupler，其中D是一种噻二唑、异噻唑、吡唑或噻吩类型的基团，而Coupler是一种苯胺、四氢喹啉或苯基吗啡啶衍生物，其中一个-ZSSO.sub.3 M基团附加到其氮上，偶联剂环可以包含取代基，如烷基、烷氧基、卤素、酰胺基、烷硫基或芳氧基，苯胺偶联剂的其余氢原子可以被取代基所取代，例如烷基、取代烷基、烯基、芳基或环烷基，M是Na.sup. +，K.sup. +，NH.sub.4.sup.+或H.sup.+，Z是如乙烯等的连接基团。
• Pyrimidinones as melanin concentrating hormone receptor 1
  申请人：——

  公开号：US20040220404A1

  公开（公告）日：2004-11-04

  A compound of formula (Ia) comprising a pharmaceutically acceptable salt or solvate thereof, formulations, processes of preparing, and methods of administering to mammals are provided 1

  提供了一种化合物(Ia)的配方，包括其药用可接受的盐或溶剂，制备过程以及对哺乳动物的给药方法。
• Process for the preparation of styryl dyestuffs
  申请人：Bayer Aktiengesellschaft

  公开号：US04088673A1

  公开（公告）日：1978-05-09

  Process for the preparation of styryl dyestuffs, characterized in that, in a one-pot reaction, amines of the general formula form ##STR1## wherein R.sub.1 denotes alkyl or aryl, R.sub.2 denotes hydrogen, alkyl or aryl, R.sub.3 -r.sub.6 denote hydrogen or non-ionic substituents, preferably alkyl, alkoxy, nitro or halogen or R.sub.1 with R.sub.3 or R.sub.5 conjointly from the remaining members of a 5-membered or 6-membered ring system which optionally contains further hetero-atoms Are treated with at least 1 equivalent of a Vilsmeier reagent, unconverted Vilsmeier reagent is decomposed, the pH value is adjusted to above 4 by addition of bases and subsequently--without any intermediate isolation--the product is treated with a methylene-active compound of the formula ##STR2## wherein X represents a nitrile or acyl group.

  制备苯乙烯偶氮染料的过程，其特征在于，在单锅反应中，一般式为##STR1##其中R.sub.1表示烷基或芳基，R.sub.2表示氢、烷基或芳基，R.sub.3-r.sub.6表示氢或非离子取代基，优选为烷基、烷氧基、硝基或卤素，或R.sub.1与R.sub.3或R.sub.5共同形成含有其他杂原子的5元环或6元环系统的其余成员，至少用1当量的威尔斯迈尔试剂处理，未反应的威尔斯迈尔试剂被分解，通过添加碱使pH值调整到4以上，随后-无需任何中间分离-将产物与一种式为##STR2##其中X表示腈基或酰基的亚甲基活性化合物处理。