4-(2,2-dimethyl-1,3-dioxolan-4-yl)butan-1-amine | 149155-41-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-(2,2-dimethyl-1,3-dioxolan-4-yl)butan-1-amine
• CAS: 149155-41-9
• 化学式: C₉H₁₉NO₂
• 分子量: 173.255
• InChiKey: DTGRVYHBWNBPMF-UHFFFAOYSA-N

物化性质

• 沸点：
  231.3±15.0 °C(Predicted)
• 密度：
  0.944±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  44.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-(2,2-dimethyl-1,3-dioxolan-4-yl)butan-1-amine 在 potassium carbonate 、 苯硫酚 、 三乙胺 、 potassium hydroxide 作用下， 以 二氯甲烷 、 水 、 N,N-二甲基甲酰胺 、 乙腈 为溶剂， 反应 14.0h， 生成 N-[4-(2,2-dimethyl-1,3-dioxolan-4-yl)butyl]-N-ethylamine
  参考文献：
  名称：

  Amodiaquine analogues containing NO-donor substructures: Synthesis and their preliminary evaluation as potential tools in the treatment of cerebral malaria

  摘要：

  The synthesis and physico-chemical properties of novel compounds obtained by conjugation of amodiaquine with moieties containing either furoxan or nitrooxy NO-donor substructures are described. The synthesised compounds were tested in vitro against both the chloroquine sensitive, 010 and the chloroquine resistant, W-2 strains of Plasmodium falciparum (P falciparum). Most of the compounds showed an antiplasmodial activity comparable to that of the parent drug. By comparing the activities of simple related structures devoid of the ability to release NO, it appears that the contribution of NO to the antiplasmodial action in vitro is marginal. All the compounds were able to relax rat aorta strips with a NO-dependent mechanism, thus showing their capacity to release NO in the vessels. A preliminary in vivo study using Plasmodium berghei ANKA-infected mice showed a trend for prolonged survival of mice with cerebral malaria treated with compound 40, which is potent and fast amodiaquine-derived NO-donor, when compared with amodiaquine alone or with compound 31, a milder NO-donor. The two compounds showed in vivo antiplasmodial activity similar to that of amodiaquine. (C) 2011 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2011.02.029
• 作为产物：
  描述：

  2-(hex-5-en-1-yl)isoindoline-1,3-dione 在 potassium permanganate 、 4-甲基苯磺酸吡啶 、 一水合肼 作用下， 以 四氢呋喃 、 水 、 丙酮 为溶剂， 反应 42.0h， 生成 4-(2,2-dimethyl-1,3-dioxolan-4-yl)butan-1-amine
  参考文献：
  名称：

  Amodiaquine analogues containing NO-donor substructures: Synthesis and their preliminary evaluation as potential tools in the treatment of cerebral malaria

  摘要：

  The synthesis and physico-chemical properties of novel compounds obtained by conjugation of amodiaquine with moieties containing either furoxan or nitrooxy NO-donor substructures are described. The synthesised compounds were tested in vitro against both the chloroquine sensitive, 010 and the chloroquine resistant, W-2 strains of Plasmodium falciparum (P falciparum). Most of the compounds showed an antiplasmodial activity comparable to that of the parent drug. By comparing the activities of simple related structures devoid of the ability to release NO, it appears that the contribution of NO to the antiplasmodial action in vitro is marginal. All the compounds were able to relax rat aorta strips with a NO-dependent mechanism, thus showing their capacity to release NO in the vessels. A preliminary in vivo study using Plasmodium berghei ANKA-infected mice showed a trend for prolonged survival of mice with cerebral malaria treated with compound 40, which is potent and fast amodiaquine-derived NO-donor, when compared with amodiaquine alone or with compound 31, a milder NO-donor. The two compounds showed in vivo antiplasmodial activity similar to that of amodiaquine. (C) 2011 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2011.02.029

文献信息

• [EN] DIASTEREOMERIC LINKING REAGENTS FOR NUCLEOTIDE PROBES<br/>[FR] RÉACTIFS DE LIAISON DIASTÉRÉOMÉRIQUES POUR SONDES NUCLÉOTIDIQUES
  申请人：BRENTANO BIOTECHNOLOGY ASS

  公开号：WO2021061154A1

  公开（公告）日：2021-04-01

  A versatile reagent with a non-nucleotide monomeric unit comprising an enantiomeric center and having a ligand, and first and second coupling groups that are linked to the non-nucleotide monomeric unit. Such a reagent permits preparation of versatile nucleotide/non-nucleotide polymers, having any desired sequence of nucleotide and non-nucleotide monomeric units, each of the latter of which bear a desired ligand. These polymers can, for example, be used as probes which can exhibit enhanced sensitivity and/or which are capable of detecting a genus of nucleotides each species of which has a common target nucleotide sequence of interest bridged by different sequences not of interest.

  一种多功能试剂，具有一个非核苷单体单元，包括一个对映中心和一个配体，以及与非核苷单体单元相连的第一和第二偶联基团。这种试剂可以制备多功能核苷酸/非核苷酸聚合物，具有任何所需的核苷酸和非核苷酸单体单元序列，其中每个后者都带有所需的配体。这些聚合物可以用作探针，可以展示增强的灵敏度和/或能够检测一类核苷酸，其中每个物种都有一个共同的感兴趣的靶核苷酸序列，通过不感兴趣的不同序列连接。