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5,10-dihydropyrido<2,3-g>quinoline-5,10-dione | 91652-10-7

中文名称
——
中文别名
——
英文名称
5,10-dihydropyrido<2,3-g>quinoline-5,10-dione
英文别名
pyrido[2,3-g]quinoline-5,10-dione
5,10-dihydropyrido<2,3-g>quinoline-5,10-dione化学式
CAS
91652-10-7
化学式
C12H6N2O2
mdl
——
分子量
210.192
InChiKey
HILDJXJQSAPDCR-UHFFFAOYSA-N
BEILSTEIN
——
EINECS
——
  • 物化性质
  • 计算性质
  • ADMET
  • 安全信息
  • SDS
  • 制备方法与用途
  • 上下游信息
  • 反应信息
  • 文献信息
  • 表征谱图
  • 同类化合物
  • 相关功能分类
  • 相关结构分类

物化性质

  • 熔点:
    >300 °C
  • 沸点:
    441.3±35.0 °C(Predicted)
  • 密度:
    1.444±0.06 g/cm3(Predicted)

计算性质

  • 辛醇/水分配系数(LogP):
    1.4
  • 重原子数:
    16
  • 可旋转键数:
    0
  • 环数:
    3.0
  • sp3杂化的碳原子比例:
    0.0
  • 拓扑面积:
    59.9
  • 氢给体数:
    0
  • 氢受体数:
    4

SDS

SDS:f86bd78e590d1b722bb1c0912b29c10d
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反应信息

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文献信息

  • Antitumour 1,5-diazaanthraquinones
    申请人:——
    公开号:US20020099066A1
    公开(公告)日:2002-07-25
    1 Compounds having formula (I) wherein R 3 , R 4 , R 7 , and R 8 are independently selected from the group consisting of hydrogen, lower alkyl, halogen, amine, mono(lower)alkylamine, di(lower)alkylamine, phenyl, or substituted phenyl possess antitumor activity and are new with the exception of the compound in which R 3 , R 4 , R 7 , R 8 are all hydrogen and the compound in which R 3 and R 7 are hydrogen, R 4 chlorine, and R 8 is a 2-nitrophenyl group.
    具有公式(I)的化合物,其中R3、R4、R7和R8独立地选自包括氢、低级烷基、卤素、胺、单(低级)烷基胺、二(低级)烷基胺、苯基或取代苯基的组,具有抗肿瘤活性,除了R3、R4、R7、R8均为氢的化合物和R3和R7为氢,R4为氯,R8为2-硝基苯基的化合物外,都是新的。
  • Antitumoral compounds
    申请人:Fernandez Antonio
    公开号:US20060014776A1
    公开(公告)日:2006-01-19
    Compounds of general formula I or a pharmaceutically acceptable salts, derivatives or prodrugs thereof are of use in treatment of cancer; wherein R 1 and R 2 are independently selected from the group consisting of hydrogen, substituted or unsubstituted C 1 -C 12 alkyl, substituted or unsubstituted C 2 -C 12 alkenyl, substituted or unsubstituted C 2 -C 12 alkynyl, C 2 -C 12 alkenylidene, substituted or unsubstituted C 3 -C 12 alkynylidene and substituted or unsubstituted C 2 -C 12 acyl.
    通式I或其药学上可接受的盐、衍生物或前药在癌症治疗中有用;其中R1和R2分别选自氢、取代或未取代的C1-C12烷基、取代或未取代的C2-C12烯基、取代或未取代的C2-C12炔基、C2-C12烯基亚甲基、取代或未取代的C3-C12炔基亚甲基和取代或未取代的C2-C12酰。
  • Photostabilizing compounds, compositions, and methods
    申请人:ELC MANAGEMENT LLC
    公开号:US11530215B2
    公开(公告)日:2022-12-20
    Heterocyclic compounds are provided. In particular, the heteroatom of the heterocyclic compound may be nitrogen. The heterocyclic compounds may demonstrate capacity of stabilizing photoactive compounds. Topical compositions comprising these heterocyclic compounds are also provided. In particular, these topical compositions further comprise photoactive compounds. Methods for stabilizing photoactive compounds are also provided. These methods comprise mixing the photoactive compounds with photostabilizing heterocyclic compounds.
    提供了杂环化合物。特别是,杂环化合物的杂原子可以是氮。这些杂环化合物可显示出稳定光活性化合物的能力。还提供了包含这些杂环化合物的外用组合物。特别是,这些外用组合物还包含光活性化合物。还提供了稳定光活性化合物的方法。这些方法包括将光活性化合物与光稳定杂环化合物混合。
  • Synthesis and structure–activity relationships of 1,5-diazaanthraquinones as antitumour compounds
    作者:Carmen Avendaño、José Marı́a Pérez、Ma̱ del Mar Blanco、Jesús Ángel de la Fuente、Sonia Manzanaro、Marı́a Jesús Vicent、Marı́a Jesús Martı́n、Nélida Salvador-Tormo、J.Carlos Menéndez
    DOI:10.1016/j.bmcl.2004.05.055
    日期:2004.8
    1,5-Diazaanthraquinone derivatives were synthesized employing single and double hetero Diels-Alder strategies. Their in vitro antitumour activity was assayed using three cell lines. Some of these compounds, specially those bearing methyl or ethyl groups at the C-3,7 positions or chloro at C-4 and methyl at C-7, showed IC50 values in the 10(-8) M range for human lung carcinoma and human melanoma, which makes them attractive candidates for further development as anticancer agents. (C) 2004 Elsevier Ltd. All rights reserved.
  • Synthesis and biological evaluation of new 1,5-diazaanthraquinones with cytotoxic activity
    作者:Sonia Manzanaro、María Jesús Vicent、María Jesús Martín、Nélida Salvador-Tormo、José María Pérez、María del Mar Blanco、Carmen Avendaño、José Carlos Menéndez、Jesús Ángel de la Fuente
    DOI:10.1016/j.bmc.2004.09.021
    日期:2004.12
    series of 1,5-diazaanthraquinone derivatives was synthesized and their in vitro cytotoxic activities were evaluated against several human cancer cell lines. The 1,5-diazaanthraquinone chromophore has been synthesized either on the basis of hetero Diels-Alder reactions involving different quinoline-5,8-diones and alpha,beta,-unsaturated aldehyde N,N-dimethylhydrazones or by thertmolysis of different arylaminotnethylene Meldrntm's acid derivatives. Some of these compounds showed cytotoxic activity comparable to that of mitoxantrone against most of the cell lines tested. Compounds 20, 30, 31 and 37 were 4-54 times more potent that mitoxantrone against A549, H 116, PSN 1 and T98G cancer cell lines but, interestingly, they were 3-16 times less potent against the human breast carcinoma SKBR3. Some structure-activity relationships are described, the most significant one being the increase in cytotoxicity resulting from the introduction of a halogen atom at the C-4 position. (C) 2004 Elsevier Ltd. All rights reserved.
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