6-nitro-[3]quinolylamine | 646996-44-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 6-nitro-[3]quinolylamine
• 英文别名: 6-Nitro-[3]chinolylamin；3-Amino-6-nitro-chinolin；6-Nitroquinolin-3-amine；6-nitroquinolin-3-amine
• CAS: 646996-44-3
• 化学式: C₉H₇N₃O₂
• 分子量: 189.173
• InChiKey: YBLUOPYUXMSESW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  14
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  84.7
• 氢给体数：
  1
• 氢受体数：
  4

安全信息

• 危险性防范说明：
  P261,P280,P301+P312,P302+P352,P305+P351+P338
• 危险性描述：
  H302,H315,H319,H335

反应信息

• 作为反应物：
  描述：

  6-nitro-[3]quinolylamine 在 palladium diacetate 、 铜 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 、 三氟乙酸 为溶剂， 反应 48.5h， 生成 5-Methyl-2-nitro-10H-indolo[3,2-b]quinolin-5-ium; iodide
  参考文献：
  名称：

  Substituted Indoloquinolines as New Antifungal Agents

  摘要：

  Cryptolepine (2) possesses desirable properties to serve as a lead in developing new antifungal agents. Using SAR techniques, several analogues of cryptolepine were designed to increase potency and to broaden the antifungal spectrum over several opportunistic microorganisms. A number of 2-substituted indoloquinolines have been synthesized and evaluated in antifungal screens and several have been shown to increase potency and expand the antifungal spectrum of cryptolepine. Comparison of MICs of a number of these analogues with standard antifungal agents, shows them to be comparable to Amphotericin B and Ketoconazole. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0968-0896(01)00401-1
• 作为产物：
  描述：

  3-溴-6-硝基喹啉 在 ammonium hydroxide 、 copper(II) sulfate 作用下， 生成 6-nitro-[3]quinolylamine
  参考文献：
  名称：

  Bendz et al., Journal of the Chemical Society, 1950, p. 1130,1137

  摘要：

  DOI：

文献信息

• [EN] QUINOLINES AS FGFR KINASE MODULATORS<br/>[FR] QUINOLINES COMME MODULATEURS DE LA FGFR KINASE
  申请人：ASTEX THERAPEUTICS LTD

  公开号：WO2013061074A1

  公开（公告）日：2013-05-02

  The invention relates to new quinoline derivative compounds of formula (I), to pharmaceutical compositions comprising said compounds, to processes for the preparation of said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer. Formula (I)

  本发明涉及公式（I）的新喹啉衍生物化合物，包括含有该化合物的制药组合物，制备该化合物的方法以及利用该化合物治疗疾病，例如癌症。公式（I）
• Bendz et al., Journal of the Chemical Society, 1950, p. 1130,1137
  作者：Bendz et al.

  DOI：——

  日期：——
• QUINOLINES AS FGFR KINASE MODULATORS
  申请人：ASTEX THERAPEUTICS LIMITED

  公开号：US20140296236A1

  公开（公告）日：2014-10-02

  The invention relates to new quinoline derivative compounds of formula (I), to pharmaceutical compositions comprising said compounds, to processes for the preparation of said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer. Formula (I)
• US9439896B2
  申请人：——

  公开号：US9439896B2

  公开（公告）日：2016-09-13
• Substituted Indoloquinolines as New Antifungal Agents
  作者：Seth Y Ablordeppey、Pingchen Fan、Shouming Li、Alice M Clark、Charles D Hufford

  DOI：10.1016/s0968-0896(01)00401-1

  日期：2002.5

  Cryptolepine (2) possesses desirable properties to serve as a lead in developing new antifungal agents. Using SAR techniques, several analogues of cryptolepine were designed to increase potency and to broaden the antifungal spectrum over several opportunistic microorganisms. A number of 2-substituted indoloquinolines have been synthesized and evaluated in antifungal screens and several have been shown to increase potency and expand the antifungal spectrum of cryptolepine. Comparison of MICs of a number of these analogues with standard antifungal agents, shows them to be comparable to Amphotericin B and Ketoconazole. (C) 2002 Elsevier Science Ltd. All rights reserved.