ar-juvabione | 17882-18-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: ar-juvabione
• 英文别名: (+/-)-ar-Juvabion；ar-(+/-)-Juvabion；ar-Juvabion；ar-Tuvabion；ar-(+)-Juvabion；Methyl 4-(6-methyl-4-oxoheptan-2-yl)benzoate
• CAS: 17882-18-7
• 化学式: C₁₆H₂₂O₃
• 分子量: 262.349
• InChiKey: HWGXPHSUTYGITL-UHFFFAOYSA-N

物化性质

• 沸点：
  135-137 °C(Press: 1 Torr)
• 密度：
  1.019±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  19
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  43.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  (+/-)-3-苯基丁酸 在 三氯化铝 、 lithium 作用下， 以 二硫化碳 为溶剂， 反应 9.0h， 生成 ar-juvabione
  参考文献：
  名称：

  Kavitake, B. P.; Desai, U. V.; Desai, D. G., Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1986, vol. 25, p. 178 - 179

  摘要：

  DOI：

文献信息

• Subrahmania Ayyar,K.; Krishna Rao,G.S., Canadian Journal of Chemistry, 1968, vol. 46, p. 1467 - 1472
  作者：Subrahmania Ayyar,K.、Krishna Rao,G.S.

  DOI：——

  日期：——
• Mane, Ramchandra B.; Desai, Uday V.; Hebbalkar, Geeta D., Collection of Czechoslovak Chemical Communications, 1988, vol. 53, # 3, p. 646 - 657
  作者：Mane, Ramchandra B.、Desai, Uday V.、Hebbalkar, Geeta D.

  DOI：——

  日期：——
• Efimova,O.V. et al., Journal of general chemistry of the USSR, 1970, vol. 40, p. 2497 - 2499
  作者：Efimova,O.V. et al.

  DOI：——

  日期：——
• MANE, RAMCHANDRA B.;DESAI, UDAY V.;HEBBALKAR, GEETA D., COLLECT. CZECHOSL. CHEM. COMMUN., 53,(1988) N 3, 646-657
  作者：MANE, RAMCHANDRA B.、DESAI, UDAY V.、HEBBALKAR, GEETA D.

  DOI：——

  日期：——
• [EN] METHOD FOR MINIMIZING THE CYTOTOXICITY OF THE EFFECTIVE AGENT IN A COMPOSITION THAT IS ADMINISTERED TO A MAMMAL OR GETS INTO CONTACT WITH A MAMMAL<br/>[FR] PROCÉDÉ POUR RÉDUIRE LA CYTOTOXICITÉ DE L'AGENT ACTIF DANS UNE COMPOSITION ADMINISTRÉE À UN MAMMIFÈRE OU VENANT EN CONTACT AVEC UN MAMMIFÈRE
  申请人：OY GRANULA AB LTD

  公开号：WO2009101261A2

  公开（公告）日：2009-08-20

  The invention relates to a mixture to be included in a composition or its semifinished product that is administered to a mammal or gets into contact with a mammal, said composition or its semifinished product containing at least one first effective agent; as well as a possible solvent system with either hydrophobic or hydrophilic nature, selected according to the target of usage; and a possible surface active agent. The mixture is obtained by pulverizing wood or plant material and/or by extracting the possibly pulverized wood or plant material, so that said mixture contains at least two different polyphenolic compounds, selected from among the group: lignans, stilbenes, juvabiones and flavonoids, said mixture also containing oligomers of said polyphenolic compounds; the mixture does not irritate the skin in a so-called single patch test; the cytotoxicity of the polyphenols contained in the mixture is at least 10 times lower with respect to BHT; the mixture has the same effective properties as the effective agent contained in the composition or its semifinished product; and the mixture also has effects for modifying the properties of the first effective agent, or effects for increasing the safety of usage of the first effective agent.